etoposide-5027 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the etoposide-5027 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
AKR1C1 aldo-keto reductase family 1, member C1
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2
APC adenomatous polyposis coli
ASTN2 astrotactin 2
BCL6 B-cell CLL/lymphoma 6
BEX4 brain expressed, X-linked 4
BLNK B-cell linker
BTG2 BTG family, member 2
CCNG2 cyclin G2
CCNK cyclin K
CDK20 cyclin-dependent kinase 20
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEL carboxyl ester lipase
CEP164 centrosomal protein 164kDa
CES2 carboxylesterase 2
CFLAR CASP8 and FADD-like apoptosis regulator
CPT2 carnitine palmitoyltransferase 2
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CRY2 cryptochrome circadian clock 2
CUL7 cullin 7
CYFIP2 cytoplasmic FMR1 interacting protein 2
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT4 DNA-damage-inducible transcript 4
DGCR8 DGCR8 microprocessor complex subunit
DGKA diacylglycerol kinase, alpha 80kDa
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5
ELN elastin
EXOC7 exocyst complex component 7
FAM214B family with sequence similarity 214, member B
FAS Fas cell surface death receptor
FBXO31 F-box protein 31
FDXR ferredoxin reductase
FKBP1B FK506 binding protein 1B, 12.6 kDa
FMO5 flavin containing monooxygenase 5
GADD45A growth arrest and DNA-damage-inducible, alpha
GM2A GM2 ganglioside activator
GPER1 G protein-coupled estrogen receptor 1
GPR87 G protein-coupled receptor 87
GRIK5 glutamate receptor, ionotropic, kainate 5
HIPK3 homeodomain interacting protein kinase 3
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KLF9 Kruppel-like factor 9
LGALS4 lectin, galactoside-binding, soluble, 4
LIF leukemia inhibitory factor
LIMK2 LIM domain kinase 2
LTBP4 latent transforming growth factor beta binding protein 4
LY6D lymphocyte antigen 6 complex, locus D
MAP2 microtubule-associated protein 2
MAP3K12 mitogen-activated protein kinase kinase kinase 12
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MST1 macrophage stimulating 1
MTCP1 mature T-cell proliferation 1
MUC3A mucin 3A, cell surface associated
MXD4 MAX dimerization protein 4
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NFX1 nuclear transcription factor, X-box binding 1
NHLH2 nescient helix loop helix 2
NOL12 nucleolar protein 12
OGFR opioid growth factor receptor
PCDHB13 protocadherin beta 13
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PNRC1 proline-rich nuclear receptor coactivator 1
PROCR protein C receptor, endothelial
RALGDS ral guanine nucleotide dissociation stimulator
RGS20 regulator of G-protein signaling 20
RND1 Rho family GTPase 1
S100A8 S100 calcium binding protein A8
SBNO1 strawberry notch homolog 1 (Drosophila)
SCAPER S-phase cyclin A-associated protein in the ER
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SESN1 sestrin 1
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1
SP1 Sp1 transcription factor
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TAPBP TAP binding protein (tapasin)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIGAR TP53 induced glycolysis regulatory phosphatase
TM7SF3 transmembrane 7 superfamily member 3
TMEM40 transmembrane protein 40
TMEM53 transmembrane protein 53
TMEM63A transmembrane protein 63A
TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
TP53I3 tumor protein p53 inducible protein 3
TRIM3 tripartite motif containing 3
TTLL3 tubulin tyrosine ligase-like family member 3
UBE2H ubiquitin-conjugating enzyme E2H
XPC xeroderma pigmentosum, complementation group C
YIPF4 Yip1 domain family, member 4
ZFP37 ZFP37 zinc finger protein
ZMAT3 zinc finger, matrin-type 3
ZNF750 zinc finger protein 750

decreased expression

Symbol Name
ARHGAP11A Rho GTPase activating protein 11A
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKB aurora kinase B
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
CCDC85C coiled-coil domain containing 85C
CCNA2 cyclin A2
CCNB1 cyclin B1
CDC20 cell division cycle 20
CDCA3 cell division cycle associated 3
CDK3 cyclin-dependent kinase 3
CDKN3 cyclin-dependent kinase inhibitor 3
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CEP55 centrosomal protein 55kDa
CEP72 centrosomal protein 72kDa
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
DBF4 DBF4 zinc finger
DEPDC1 DEP domain containing 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DSCAM Down syndrome cell adhesion molecule
DUSP2 dual specificity phosphatase 2
DYSF dysferlin
E2F8 E2F transcription factor 8
ERCC6L excision repair cross-complementation group 6-like
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
FAM64A family with sequence similarity 64, member A
GAB2 GRB2-associated binding protein 2
GJA1 gap junction protein, alpha 1, 43kDa
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GPSM2 G-protein signaling modulator 2
GRTP1 growth hormone regulated TBC protein 1
HIST1H2AG histone cluster 1, H2ag
HIST1H2BJ histone cluster 1, H2bj
HIST1H3B histone cluster 1, H3b
HJURP Holliday junction recognition protein
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
IFRD1 interferon-related developmental regulator 1
IFT140 intraflagellar transport 140
ITPKB inositol-trisphosphate 3-kinase B
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KIAA0319L KIAA0319-like
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF18A kinesin family member 18A
KIF20A kinesin family member 20A
KIF20B kinesin family member 20B
KIF23 kinesin family member 23
KIF4A kinesin family member 4A
KLHL36 kelch-like family member 36
LHX6 LIM homeobox 6
LMNB1 lamin B1
MATK megakaryocyte-associated tyrosine kinase
MKI67 marker of proliferation Ki-67
MSI1 musashi RNA-binding protein 1
NCAPG non-SMC condensin I complex, subunit G
NCAPH non-SMC condensin I complex, subunit H
NDC80 NDC80 kinetochore complex component
NDE1 nudE neurodevelopment protein 1
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NEK2 NIMA-related kinase 2
NME5 NME/NM23 family member 5
PER3 period circadian clock 3
PLEKHO1 pleckstrin homology domain containing, family O member 1
PLK1 polo-like kinase 1
PPP6R2 protein phosphatase 6, regulatory subunit 2
PRC1 protein regulator of cytokinesis 1
PRR11 proline rich 11
PSRC1 proline/serine-rich coiled-coil 1
PTTG1 pituitary tumor-transforming 1
RACGAP1 Rac GTPase activating protein 1
RECQL4 RecQ protein-like 4
RNF2 ring finger protein 2
RPP25 ribonuclease P/MRP 25kDa subunit
SIX1 SIX homeobox 1
SLMO1 slowmo homolog 1 (Drosophila)
SPAG5 sperm associated antigen 5
STIL SCL/TAL1 interrupting locus
SUN2 Sad1 and UNC84 domain containing 2
SYBU syntabulin (syntaxin-interacting)
TACC3 transforming, acidic coiled-coil containing protein 3
TCHH trichohyalin
TEX40 testis expressed 40
TPK1 thiamin pyrophosphokinase 1
TPX2 TPX2, microtubule-associated
TRABD TraB domain containing
TROAP trophinin associated protein
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TTK TTK protein kinase
TUBA3C tubulin, alpha 3c
TUBA4B tubulin, alpha 4b
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
XK X-linked Kx blood group
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZNF165 zinc finger protein 165
ZNF639 zinc finger protein 639