ethionamide-4593 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the ethionamide-4593 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9
ADRA2C adrenoceptor alpha 2C
AFF1 AF4/FMR2 family, member 1
ALDOB aldolase B, fructose-bisphosphate
ALOXE3 arachidonate lipoxygenase 3
APOM apolipoprotein M
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASPHD1 aspartate beta-hydroxylase domain containing 1
B3GNTL1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1
BMPR1B bone morphogenetic protein receptor, type IB
C1ORF105 chromosome 1 open reading frame 105
C8A complement component 8, alpha polypeptide
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP2 caspase 2, apoptosis-related cysteine peptidase
CAV2 caveolin 2
CCDC7 coiled-coil domain containing 7
CGA glycoprotein hormones, alpha polypeptide
CHRDL1 chordin-like 1
CLEC11A C-type lectin domain family 11, member A
CNTNAP2 contactin associated protein-like 2
COL2A1 collagen, type II, alpha 1
CREM cAMP responsive element modulator
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DHRS12 dehydrogenase/reductase (SDR family) member 12
DOCK5 dedicator of cytokinesis 5
EPX eosinophil peroxidase
ETV1 ets variant 1
EYA3 EYA transcriptional coactivator and phosphatase 3
FAM110B family with sequence similarity 110, member B
FAM174B family with sequence similarity 174, member B
FCF1 FCF1 rRNA-processing protein
FLT1 fms-related tyrosine kinase 1
FOSL2 FOS-like antigen 2
FRMD8 FERM domain containing 8
GAB1 GRB2-associated binding protein 1
GK glycerol kinase
GK3P glycerol kinase 3 pseudogene
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPR1 G protein-coupled receptor 1
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HSPG2 heparan sulfate proteoglycan 2
IGHD immunoglobulin heavy constant delta
IL36A interleukin 36, alpha
IQSEC2 IQ motif and Sec7 domain 2
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KRIT1 KRIT1, ankyrin repeat containing
LY86 lymphocyte antigen 86
MAP3K13 mitogen-activated protein kinase kinase kinase 13
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
MECOM MDS1 and EVI1 complex locus
MMP11 matrix metallopeptidase 11
MORC1 MORC family CW-type zinc finger 1
MPZ myelin protein zero
MTA2 metastasis associated 1 family, member 2
MUC8 mucin 8
MVD mevalonate (diphospho) decarboxylase
NOL12 nucleolar protein 12
NRP2 neuropilin 2
OAZ3 ornithine decarboxylase antizyme 3
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDE4D phosphodiesterase 4D, cAMP-specific
PDE4DIP phosphodiesterase 4D interacting protein
PECAM1 platelet/endothelial cell adhesion molecule 1
PKNOX2 PBX/knotted 1 homeobox 2
PML promyelocytic leukemia
POFUT1 protein O-fucosyltransferase 1
PPIAL4A peptidylprolyl isomerase A (cyclophilin A)-like 4A
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
PRKCI protein kinase C, iota
RABGAP1L RAB GTPase activating protein 1-like
RFXAP regulatory factor X-associated protein
RLN1 relaxin 1
RNF6 ring finger protein (C3H2C3 type) 6
RUNX1 runt-related transcription factor 1
SHOX2 short stature homeobox 2
SLC16A6 solute carrier family 16, member 6
SMEK1 SMEK homolog 1, suppressor of mek1 (Dictyostelium)
SPHK2 sphingosine kinase 2
STC1 stanniocalcin 1
STK3 serine/threonine kinase 3
STOML1 stomatin (EPB72)-like 1
SYNE1 spectrin repeat containing, nuclear envelope 1
TCL6 T-cell leukemia/lymphoma 6 (non-protein coding)
THBS1 thrombospondin 1
THRB thyroid hormone receptor, beta
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TPM1 tropomyosin 1 (alpha)
TRIL TLR4 interactor with leucine-rich repeats
VNN3 vanin 3
VWA5A von Willebrand factor A domain containing 5A
WFDC2 WAP four-disulfide core domain 2
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1
WIPF1 WAS/WASL interacting protein family, member 1
ZBTB6 zinc finger and BTB domain containing 6

decreased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ADGRB2 adhesion G protein-coupled receptor B2
ALS2CL ALS2 C-terminal like
ANP32A-IT1 ANP32A intronic transcript 1
ARL14 ADP-ribosylation factor-like 14
ASB7 ankyrin repeat and SOCS box containing 7
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide
AURKC aurora kinase C
C19ORF40 chromosome 19 open reading frame 40
CCDC85C coiled-coil domain containing 85C
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CDON cell adhesion associated, oncogene regulated
CENPO centromere protein O
CEP112 centrosomal protein 112kDa
CEP97 centrosomal protein 97kDa
CLSTN3 calsyntenin 3
CNTNAP3B contactin associated protein-like 3B
CPEB1 cytoplasmic polyadenylation element binding protein 1
CPNE7 copine VII
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CXCL3 chemokine (C-X-C motif) ligand 3
DCLRE1A DNA cross-link repair 1A
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
DSPP dentin sialophosphoprotein
EDIL3 EGF-like repeats and discoidin I-like domains 3
EFNA3 ephrin-A3
EHF ets homologous factor
ETNK2 ethanolamine kinase 2
FAM53B family with sequence similarity 53, member B
FBRS fibrosin
FBXL7 F-box and leucine-rich repeat protein 7
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GRAMD1C GRAM domain containing 1C
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIST1H2AM histone cluster 1, H2am
HIST1H4A histone cluster 1, H4a
HLA-DMA major histocompatibility complex, class II, DM alpha
HOXA1 homeobox A1
HOXB9 homeobox B9
HOXC8 homeobox C8
INCENP inner centromere protein antigens 135/155kDa
KLK5 kallikrein-related peptidase 5
LOC100287590 uncharacterized LOC100287590
LOC257152 uncharacterized LOC257152
MAPK12 mitogen-activated protein kinase 12
MEGF8 multiple EGF-like-domains 8
MT1M metallothionein 1M
MTMR11 myotubularin related protein 11
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PDZD2 PDZ domain containing 2
PID1 phosphotyrosine interaction domain containing 1
PLA2G15 phospholipase A2, group XV
POM121 POM121 transmembrane nucleoporin
POMT2 protein-O-mannosyltransferase 2
PROX1 prospero homeobox 1
PRR14L proline rich 14-like
RAB3A RAB3A, member RAS oncogene family
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RNF126P1 ring finger protein 126 pseudogene 1
SARS2 seryl-tRNA synthetase 2, mitochondrial
SCAMP5 secretory carrier membrane protein 5
SCGB2A2 secretoglobin, family 2A, member 2
SCML2 sex comb on midleg-like 2 (Drosophila)
SCN8A sodium channel, voltage gated, type VIII alpha subunit
SMA4 glucuronidase, beta pseudogene
SPTBN2 spectrin, beta, non-erythrocytic 2
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
TCTN2 tectonic family member 2
TM6SF1 transmembrane 6 superfamily member 1
TMEM121 transmembrane protein 121
TMEM53 transmembrane protein 53
TRAF2 TNF receptor-associated factor 2
TSPAN2 tetraspanin 2
TTC23 tetratricopeptide repeat domain 23
TTC30A tetratricopeptide repeat domain 30A
TUBA4B tubulin, alpha 4b
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
USP19 ubiquitin specific peptidase 19
USP27X ubiquitin specific peptidase 27, X-linked
VEZT vezatin, adherens junctions transmembrane protein
VGF VGF nerve growth factor inducible
VN1R1 vomeronasal 1 receptor 1
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZC3H12A zinc finger CCCH-type containing 12A
ZNF205 zinc finger protein 205
ZNF334 zinc finger protein 334
ZNF528 zinc finger protein 528
ZNF778 zinc finger protein 778
ZXDC ZXD family zinc finger C