estradiol-6200 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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196 genes differentially expressed following the estradiol-6200 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTN2 actinin, alpha 2
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
AGFG2 ArfGAP with FG repeats 2
AHI1 Abelson helper integration site 1
AKAP8L A kinase (PRKA) anchor protein 8-like
ALDOB aldolase B, fructose-bisphosphate
ALOX5 arachidonate 5-lipoxygenase
AQP9 aquaporin 9
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1
BCL9 B-cell CLL/lymphoma 9
BIN1 bridging integrator 1
BMP7 bone morphogenetic protein 7
BTF3P11 basic transcription factor 3 pseudogene 11
C17ORF59 chromosome 17 open reading frame 59
C1ORF68 chromosome 1 open reading frame 68
C5ORF45 chromosome 5 open reading frame 45
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2
CDC14B cell division cycle 14B
CDK10 cyclin-dependent kinase 10
CHRM3 cholinergic receptor, muscarinic 3
CLCN4 chloride channel, voltage-sensitive 4
CLEC4A C-type lectin domain family 4, member A
COL1A1 collagen, type I, alpha 1
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CSF1 colony stimulating factor 1 (macrophage)
CYLD cylindromatosis (turban tumor syndrome)
DDR1 discoidin domain receptor tyrosine kinase 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DPEP2 dipeptidase 2
DPP4 dipeptidyl-peptidase 4
EHD1 EH-domain containing 1
EPS8L1 EPS8-like 1
FABP3 fatty acid binding protein 3, muscle and heart
FCN3 ficolin (collagen/fibrinogen domain containing) 3
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3
GM2A GM2 ganglioside activator
GPR153 G protein-coupled receptor 153
GPX2 glutathione peroxidase 2
HHLA1 HERV-H LTR-associating 1
HIC2 hypermethylated in cancer 2
HPD 4-hydroxyphenylpyruvate dioxygenase
IGL immunoglobulin lambda locus
IL5RA interleukin 5 receptor, alpha
INHBA inhibin, beta A
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KDM4B lysine (K)-specific demethylase 4B
KHK ketohexokinase (fructokinase)
KLHL36 kelch-like family member 36
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LINC00260 long intergenic non-protein coding RNA 260
LMF1 lipase maturation factor 1
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
MCPH1 microcephalin 1
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
MIOS missing oocyte, meiosis regulator, homolog (Drosophila)
MSRB2 methionine sulfoxide reductase B2
MUC3B mucin 3B, cell surface associated
MUC8 mucin 8
NCAN neurocan
NCOR2 nuclear receptor corepressor 2
NIPAL2 NIPA-like domain containing 2
NOP16 NOP16 nucleolar protein
NPTX1 neuronal pentraxin I
NR4A2 nuclear receptor subfamily 4, group A, member 2
PCBP3 poly(rC) binding protein 3
PDE11A phosphodiesterase 11A
PDLIM5 PDZ and LIM domain 5
PER3 period circadian clock 3
PGLYRP1 peptidoglycan recognition protein 1
PLEKHA6 pleckstrin homology domain containing, family A member 6
PLIN2 perilipin 2
PLXDC1 plexin domain containing 1
PON1 paraoxonase 1
PVR poliovirus receptor
QPCTL glutaminyl-peptide cyclotransferase-like
RAB3D RAB3D, member RAS oncogene family
RAB6B RAB6B, member RAS oncogene family
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SIN3B SIN3 transcription regulator family member B
SLC1A7 solute carrier family 1 (glutamate transporter), member 7
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SORBS3 sorbin and SH3 domain containing 3
SOX4 SRY (sex determining region Y)-box 4
SP100 SP100 nuclear antigen
SSPN sarcospan
ST7L suppression of tumorigenicity 7 like
TFF2 trefoil factor 2
THBS1 thrombospondin 1
TMEM53 transmembrane protein 53
TMLHE trimethyllysine hydroxylase, epsilon
TP63 tumor protein p63
TPM3 tropomyosin 3
TRIM3 tripartite motif containing 3
TRPM8 transient receptor potential cation channel, subfamily M, member 8
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble

decreased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ADGRG2 adhesion G protein-coupled receptor G2
ADTRP androgen-dependent TFPI-regulating protein
AICDA activation-induced cytidine deaminase
AIM2 absent in melanoma 2
AMDHD2 amidohydrolase domain containing 2
BCAR3 breast cancer anti-estrogen resistance 3
BCAS3 breast carcinoma amplified sequence 3
BMP15 bone morphogenetic protein 15
BZRAP1 benzodiazepine receptor (peripheral) associated protein 1
C2ORF54 chromosome 2 open reading frame 54
C4ORF19 chromosome 4 open reading frame 19
CAPN5 calpain 5
CCDC71 coiled-coil domain containing 71
CCL20 chemokine (C-C motif) ligand 20
CD1C CD1c molecule
CDK3 cyclin-dependent kinase 3
CLCN5 chloride channel, voltage-sensitive 5
CNTN1 contactin 1
COLEC12 collectin sub-family member 12
COPG2IT1 COPG2 imprinted transcript 1 (non-protein coding)
CPTP ceramide-1-phosphate transfer protein
CRABP2 cellular retinoic acid binding protein 2
CRY2 cryptochrome circadian clock 2
CUX2 cut-like homeobox 2
DDN dendrin
DEAF1 DEAF1 transcription factor
DFNA5 deafness, autosomal dominant 5
DGKE diacylglycerol kinase, epsilon 64kDa
DPY19L2P2 DPY19L2 pseudogene 2
DSPP dentin sialophosphoprotein
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
ERCC6 excision repair cross-complementation group 6
EXO5 exonuclease 5
FAM86C1 family with sequence similarity 86, member C1
FBXO22 F-box protein 22
FRMD1 FERM domain containing 1
GAA glucosidase, alpha; acid
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GDAP1 ganglioside induced differentiation associated protein 1
GID4 GID complex subunit 4
GNG4 guanine nucleotide binding protein (G protein), gamma 4
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4
HTRA1 HtrA serine peptidase 1
IFNA17 interferon, alpha 17
IGFBP4 insulin-like growth factor binding protein 4
IL11RA interleukin 11 receptor, alpha
IMPAD1 inositol monophosphatase domain containing 1
INA internexin neuronal intermediate filament protein, alpha
KIAA1107 KIAA1107
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
KLRG1 killer cell lectin-like receptor subfamily G, member 1
LIMS2 LIM and senescent cell antigen-like domains 2
LOC100286895 cell division cycle 27 homolog pseudogene
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1
LRP2 low density lipoprotein receptor-related protein 2
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
MMP3 matrix metallopeptidase 3
NPFFR1 neuropeptide FF receptor 1
OR2B6 olfactory receptor, family 2, subfamily B, member 6
P2RY1 purinergic receptor P2Y, G-protein coupled, 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PHACTR1 phosphatase and actin regulator 1
PHOX2A paired-like homeobox 2a
PITX2 paired-like homeodomain 2
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRAF2 PRA1 domain family, member 2
PRKCE protein kinase C, epsilon
PRSS12 protease, serine, 12 (neurotrypsin, motopsin)
PSG4 pregnancy specific beta-1-glycoprotein 4
RANBP17 RAN binding protein 17
RCAN3 RCAN family member 3
S100A13 S100 calcium binding protein A13
SAA4 serum amyloid A4, constitutive
SCUBE2 signal peptide, CUB domain, EGF-like 2
SEC14L5 SEC14-like 5 (S. cerevisiae)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SETD8 SET domain containing (lysine methyltransferase) 8
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1
SLC16A6 solute carrier family 16, member 6
SLC17A2 solute carrier family 17, member 2
SOX12 SRY (sex determining region Y)-box 12
SOX21 SRY (sex determining region Y)-box 21
SP140 SP140 nuclear body protein
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TAOK1 TAO kinase 1
TBC1D17 TBC1 domain family, member 17
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TTLL1 tubulin tyrosine ligase-like family member 1
URGCP upregulator of cell proliferation
USB1 U6 snRNA biogenesis 1
ZNF205 zinc finger protein 205
ZNF552 zinc finger protein 552
ZNF695 zinc finger protein 695
ZNF816 zinc finger protein 816