estradiol-2653 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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196 genes differentially expressed following the estradiol-2653 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A1CF APOBEC1 complementation factor
AAK1 AP2 associated kinase 1
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABHD2 abhydrolase domain containing 2
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANXA2P3 annexin A2 pseudogene 3
APLP2 amyloid beta (A4) precursor-like protein 2
AREG amphiregulin
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
BHLHE40 basic helix-loop-helix family, member e40
BRCA2 breast cancer 2, early onset
C3 complement component 3
CA4 carbonic anhydrase IV
CD70 CD70 molecule
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHRM3 cholinergic receptor, muscarinic 3
DLGAP4 discs, large (Drosophila) homolog-associated protein 4
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DNMBP dynamin binding protein
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DUSP2 dual specificity phosphatase 2
EGR3 early growth response 3
EIF5B eukaryotic translation initiation factor 5B
ELF2 E74-like factor 2 (ets domain transcription factor)
FAM76A family with sequence similarity 76, member A
FBXO21 F-box protein 21
FOXG1 forkhead box G1
FXR2 fragile X mental retardation, autosomal homolog 2
GLP1R glucagon-like peptide 1 receptor
HOXC8 homeobox C8
HR hair growth associated
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IQSEC2 IQ motif and Sec7 domain 2
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
LAMP3 lysosomal-associated membrane protein 3
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4
LRP6 low density lipoprotein receptor-related protein 6
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MBIP MAP3K12 binding inhibitory protein 1
MED28 mediator complex subunit 28
MID2 midline 2
MITF microphthalmia-associated transcription factor
MKL1 megakaryoblastic leukemia (translocation) 1
MOCS1 molybdenum cofactor synthesis 1
MTM1 myotubularin 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NBL1 neuroblastoma 1, DAN family BMP antagonist
NCALD neurocalcin delta
NCS1 neuronal calcium sensor 1
NOL12 nucleolar protein 12
NOP16 NOP16 nucleolar protein
NR2C1 nuclear receptor subfamily 2, group C, member 1
PDHA2 pyruvate dehydrogenase (lipoamide) alpha 2
PER1 period circadian clock 1
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POU2F2 POU class 2 homeobox 2
PPM1F protein phosphatase, Mg2+/Mn2+ dependent, 1F
PPP5C protein phosphatase 5, catalytic subunit
PRKCI protein kinase C, iota
PSPH phosphoserine phosphatase
PTGDS prostaglandin D2 synthase 21kDa (brain)
RBPJ recombination signal binding protein for immunoglobulin kappa J region
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHOQ ras homolog family member Q
RNGTT RNA guanylyltransferase and 5'-phosphatase
RPL10 ribosomal protein L10
RPL23AP32 ribosomal protein L23a pseudogene 32
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SAV1 salvador family WW domain containing protein 1
SEC24A SEC24 family member A
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLMO1 slowmo homolog 1 (Drosophila)
SOCS5 suppressor of cytokine signaling 5
SPDEF SAM pointed domain containing ETS transcription factor
SPON2 spondin 2, extracellular matrix protein
SPTBN1 spectrin, beta, non-erythrocytic 1
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
STARD8 StAR-related lipid transfer (START) domain containing 8
SUN1 Sad1 and UNC84 domain containing 1
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
SWAP70 SWAP switching B-cell complex 70kDa subunit
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
TBC1D2B TBC1 domain family, member 2B
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TGM2 transglutaminase 2
TMEM120B transmembrane protein 120B
TRIM29 tripartite motif containing 29
UTRN utrophin
VEGFA vascular endothelial growth factor A
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae)
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF696 zinc finger protein 696
ZNF747 zinc finger protein 747
ZNF778 zinc finger protein 778

decreased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ARID3A AT rich interactive domain 3A (BRIGHT-like)
BMP4 bone morphogenetic protein 4
C17ORF80 chromosome 17 open reading frame 80
C19ORF73 chromosome 19 open reading frame 73
C1QTNF3 C1q and tumor necrosis factor related protein 3
C22ORF46 chromosome 22 open reading frame 46
C2ORF27A chromosome 2 open reading frame 27A
C5AR2 complement component 5a receptor 2
C9ORF9 chromosome 9 open reading frame 9
CBX7 chromobox homolog 7
CCDC25 coiled-coil domain containing 25
CCNO cyclin O
CDK3 cyclin-dependent kinase 3
CLCF1 cardiotrophin-like cytokine factor 1
CLDN9 claudin 9
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CTSV cathepsin V
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DEAF1 DEAF1 transcription factor
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
DNM1 dynamin 1
EFNA1 ephrin-A1
EMID1 EMI domain containing 1
EPHA4 EPH receptor A4
ERN2 endoplasmic reticulum to nucleus signaling 2
EXD3 exonuclease 3'-5' domain containing 3
EXO5 exonuclease 5
FCHSD2 FCH and double SH3 domains 2
FILIP1L filamin A interacting protein 1-like
FLCN folliculin
FPGS folylpolyglutamate synthase
FURIN furin (paired basic amino acid cleaving enzyme)
GAMT guanidinoacetate N-methyltransferase
GINS4 GINS complex subunit 4 (Sld5 homolog)
GPR157 G protein-coupled receptor 157
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
HYI hydroxypyruvate isomerase (putative)
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase
JMJD4 jumonji domain containing 4
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
LARP6 La ribonucleoprotein domain family, member 6
LIG4 ligase IV, DNA, ATP-dependent
LRRC61 leucine rich repeat containing 61
LY6D lymphocyte antigen 6 complex, locus D
LYPD1 LY6/PLAUR domain containing 1
MCOLN3 mucolipin 3
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MYO1F myosin IF
NDE1 nudE neurodevelopment protein 1
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NNAT neuronatin
NSD1 nuclear receptor binding SET domain protein 1
PCDHB3 protocadherin beta 3
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
POLL polymerase (DNA directed), lambda
PRDM1 PR domain containing 1, with ZNF domain
PRICKLE3 prickle homolog 3 (Drosophila)
RABL6 RAB, member RAS oncogene family-like 6
RASAL1 RAS protein activator like 1 (GAP1 like)
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RIN2 Ras and Rab interactor 2
RPL13P5 ribosomal protein L13 pseudogene 5
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
RSG1 REM2 and RAB-like small GTPase 1
SAA4 serum amyloid A4, constitutive
SECTM1 secreted and transmembrane 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SETD8 SET domain containing (lysine methyltransferase) 8
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SSTR5 somatostatin receptor 5
TEP1 telomerase-associated protein 1
TINF2 TERF1 (TRF1)-interacting nuclear factor 2
TMEM121 transmembrane protein 121
TMEM212 transmembrane protein 212
TONSL tonsoku-like, DNA repair protein
TRIM21 tripartite motif containing 21
TUBA3C tubulin, alpha 3c
UNC119 unc-119 homolog (C. elegans)
USP20 ubiquitin specific peptidase 20
VASH1 vasohibin 1
VPS9D1 VPS9 domain containing 1
XAB2 XPA binding protein 2
YIF1B Yip1 interacting factor homolog B (S. cerevisiae)
ZDHHC14 zinc finger, DHHC-type containing 14
ZNF446 zinc finger protein 446