esophageal neoplasm Gene Set

Dataset GWASdb SNP-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description A tumor (abnormal growth of tissue) of the esophagus. (Human Phenotype Ontology, HP_0100751)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/HP:0100751
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Genes

125 genes associated with the esophageal neoplasm phenotype in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.

Symbol Name Standardized Value
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 2.011
PLCE1 phospholipase C, epsilon 1 1.91411
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 1.63973
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 1.45197
CHEK2 checkpoint kinase 2 1.1728
RUNX1 runt-related transcription factor 1 1.15629
ACAD10 acyl-CoA dehydrogenase family, member 10 1.13029
BARX1 BARX homeobox 1 1.12851
HEATR3 HEAT repeat containing 3 1.11616
SLC52A3 solute carrier family 52 (riboflavin transporter), member 3 1.10836
PDE4D phosphodiesterase 4D, cAMP-specific 1.07874
CRTC1 CREB regulated transcription coactivator 1 1.05869
PTPDC1 protein tyrosine phosphatase domain containing 1 1.00059
SPARCL1 SPARC-like 1 (hevin) 0.942765
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 0.919744
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2 0.844346
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 0.833606
XBP1 X-box binding protein 1 0.797287
CHRM2 cholinergic receptor, muscarinic 2 0.758119
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.740245
ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide 0.705442
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 0.693269
FCRL6 Fc receptor-like 6 0.688627
TRAFD1 TRAF-type zinc finger domain containing 1 0.528442
BRAP BRCA1 associated protein 0.527872
CCDC63 coiled-coil domain containing 63 0.524401
SMG6 SMG6 nonsense mediated mRNA decay factor 0.504644
PTPN2 protein tyrosine phosphatase, non-receptor type 2 0.504644
SLC22A17 solute carrier family 22, member 17 0.499325
FLJ45872 0.451389
AOX1 aldehyde oxidase 1 0.444167
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.444141
PES1 pescadillo ribosomal biogenesis factor 1 0.427625
SYK spleen tyrosine kinase 0.426343
NANP N-acetylneuraminic acid phosphatase 0.418889
KCNQ2 potassium channel, voltage gated KQT-like subfamily Q, member 2 0.410745
CSNK1A1 casein kinase 1, alpha 1 0.410522
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 0.409593
HSP90AA6P heat shock protein 90kDa alpha (cytosolic), class A member 6, pseudogene 0.408261
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae) 0.406755
SLC39A6 solute carrier family 39 (zinc transporter), member 6 0.400092
SEMA5B sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B 0.394839
OCA2 oculocutaneous albinism II 0.39472
TMC1 transmembrane channel-like 1 0.394321
MTAP methylthioadenosine phosphorylase 0.39353
PEBP4 phosphatidylethanolamine-binding protein 4 0.391831
CDH17 cadherin 17, LI cadherin (liver-intestine) 0.39077
FKBP1A FK506 binding protein 1A, 12kDa 0.390023
MCC mutated in colorectal cancers 0.389848
KANK1 KN motif and ankyrin repeat domains 1 0.389033
CLN3 ceroid-lipofuscinosis, neuronal 3 0.388557
WWOX WW domain containing oxidoreductase 0.387938
SREBF2 sterol regulatory element binding transcription factor 2 0.387844
DGKH diacylglycerol kinase, eta 0.387507
TFDP1 transcription factor Dp-1 0.3873
IKZF3 IKAROS family zinc finger 3 (Aiolos) 0.385955
MUC1 mucin 1, cell surface associated 0.384544
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 0.384544
TSPAN11 tetraspanin 11 0.382253
ZFAND5 zinc finger, AN1-type domain 5 0.382202
CCDC101 coiled-coil domain containing 101 0.381935
TEX41 testis expressed 41 (non-protein coding) 0.381628
FAM167A family with sequence similarity 167, member A 0.381394
ST6GAL2 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 0.380986
CUBN cubilin (intrinsic factor-cobalamin receptor) 0.379662
IL18R1 interleukin 18 receptor 1 0.378945
JAZF1 JAZF zinc finger 1 0.378841
AMPH amphiphysin 0.378704
TBL2 transducin (beta)-like 2 0.378491
TRPC4 transient receptor potential cation channel, subfamily C, member 4 0.378403
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 0.377479
AGBL4 ATP/GTP binding protein-like 4 0.377303
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.375162
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 0.374943
PTPRM protein tyrosine phosphatase, receptor type, M 0.374943
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide 0.373989
ATF1 activating transcription factor 1 0.373611
POSTN periostin, osteoblast specific factor 0.372514
USP18 ubiquitin specific peptidase 18 0.372041
DOCK9 dedicator of cytokinesis 9 0.371739
JAZF1-AS1 JAZF1 antisense RNA 1 0.371496
AXDND1 axonemal dynein light chain domain containing 1 0.369648
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 0.369269
ATXN2L ataxin 2-like 0.3688
SPNS1 spinster homolog 1 (Drosophila) 0.367503
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.367503
LOC646762 uncharacterized LOC646762 0.366566
CADM2 cell adhesion molecule 2 0.366539
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 0.366459
THOC5 THO complex 5 0.366406
CLYBL citrate lyase beta like 0.365846
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.365555
IL1RAP interleukin 1 receptor accessory protein 0.365437
BCAT1 branched chain amino-acid transaminase 1, cytosolic 0.364463
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like 0.362407
HCG18 HLA complex group 18 (non-protein coding) 0.361818
DOCK2 dedicator of cytokinesis 2 0.361361
ABHD6 abhydrolase domain containing 6 0.361234
KIAA0368 KIAA0368 0.361218
GRID1 glutamate receptor, ionotropic, delta 1 0.360941
AGBL1 ATP/GTP binding protein-like 1 0.360941
OSMR oncostatin M receptor 0.359615
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 0.359281
BPTF bromodomain PHD finger transcription factor 0.356996
FRMD3 FERM domain containing 3 0.355981
ADH6 alcohol dehydrogenase 6 (class V) 0.354128
CCDC117 coiled-coil domain containing 117 0.353812
ESRRG estrogen-related receptor gamma 0.351723
TSC22D2 TSC22 domain family, member 2 0.351058
BDNF-AS BDNF antisense RNA 0.351
FADS1 fatty acid desaturase 1 0.350364
PCDH7 protocadherin 7 0.349898
MTMR3 myotubularin related protein 3 0.3477
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.346945
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 0.346945
MFHAS1 malignant fibrous histiocytoma amplified sequence 1 0.341356
LECT1 leukocyte cell derived chemotaxin 1 0.335794
TMCC1 transmembrane and coiled-coil domain family 1 0.331025
EPHB1 EPH receptor B1 0.326442
OSBPL10 oxysterol binding protein-like 10 0.321668
OTX2-AS1 OTX2 antisense RNA 1 (head to head) 0.318505
DSG3 desmoglein 3 0.317402
CAMTA1 calmodulin binding transcription activator 1 0.312885
ELP2 elongator acetyltransferase complex subunit 2 0.31024
MIR99AHG mir-99a-let-7c cluster host gene 0.292365