esc/e(z) complex Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. In mammals the core subunits of the complex include EED, EZH2, SUZ12 and RBBP4. (Gene Ontology, GO_0035098)
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Genes

55 proteins co-occuring with the esc/e(z) complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
SUZ12 SUZ12 polycomb repressive complex 2 subunit 2.18742
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 2.18006
AEBP2 AE binding protein 2 1.42036
PHF19 PHD finger protein 19 1.39406
HIST2H3PS2 histone cluster 2, H3, pseudogene 2 1.23661
H3F3B H3 histone, family 3B (H3.3B) 1.23192
H3F3A H3 histone, family 3A 1.23192
JARID2 jumonji, AT rich interactive domain 2 1.20447
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit 1.17363
MTF2 metal response element binding transcription factor 2 1.07663
PRC1 protein regulator of cytokinesis 1 0.924666
EED embryonic ectoderm development 0.873647
PHF1 PHD finger protein 1 0.843778
PJA1 praja ring finger 1, E3 ubiquitin protein ligase 0.837351
KDM6B lysine (K)-specific demethylase 6B 0.761797
ASXL1 additional sex combs like transcriptional regulator 1 0.750904
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial 0.736913
KDM6A lysine (K)-specific demethylase 6A 0.72258
SOX21 SRY (sex determining region Y)-box 21 0.704831
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 0.685954
MIR214 microRNA 214 0.661208
BRWD1 bromodomain and WD repeat domain containing 1 0.648291
HOXA9 homeobox A9 0.565092
HOXB9 homeobox B9 0.564262
SLBP stem-loop binding protein 0.556387
U2AF1 U2 small nuclear RNA auxiliary factor 1 0.553491
TRIM10 tripartite motif containing 10 0.515308
UBN1 ubinuclein 1 0.510418
TRIM26 tripartite motif containing 26 0.509604
TRIM15 tripartite motif containing 15 0.499042
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 0.477636
HOXB1 homeobox B1 0.461998
E2F6 E2F transcription factor 6 0.446069
TBX3 T-box 3 0.44052
STAG3 stromal antigen 3 0.43696
PIAS2 protein inhibitor of activated STAT, 2 0.435775
DNMT3L DNA (cytosine-5-)-methyltransferase 3-like 0.425531
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 0.41886
ETV6 ets variant 6 0.329837
KMT2B lysine (K)-specific methyltransferase 2B 0.318953
FLI1 Fli-1 proto-oncogene, ETS transcription factor 0.314091
PBX1 pre-B-cell leukemia homeobox 1 0.302168
SOX2 SRY (sex determining region Y)-box 2 0.294378
HOXD9 homeobox D9 0.288829
VIL1 villin 1 0.287352
GATA6 GATA binding protein 6 0.264215
TAF8 TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa 0.206423
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.199993
DDB1 damage-specific DNA binding protein 1, 127kDa 0.191777
ZP2 zona pellucida glycoprotein 2 (sperm receptor) 0.186708
MPL MPL proto-oncogene, thrombopoietin receptor 0.177439
STMN1 stathmin 1 0.165
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1 0.161693
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 0.158502
STAT5B signal transducer and activator of transcription 5B 0.157943