enlarged floor plate Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description increased size of the specialized glial structure (non-neuronal cells) situated at the ventral midline of the embryonic neural tube; this structure spans the anteroposterior axis from the midbrain to the tail regions, separating the left and right basal plates of the developing neural tube, and serves as an organizer to ventralize tissues in the embryo as well as to guide neuronal positioning and differentiation along the dorsoventral axis of the neural tube (Mammalian Phenotype Ontology, MP_0012675)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0012675
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Genes

5 gene mutations causing the enlarged floor plate phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
DLL1 delta-like 1 (Drosophila)
GPR161 G protein-coupled receptor 161
PTK7 protein tyrosine kinase 7 (inactive)
RTEL1 regulator of telomere elongation helicase 1
VANGL2 VANGL planar cell polarity protein 2