endochondral bone Gene Set

Dataset TISSUES Text-mining Tissue Protein Expression Evidence Scores
Category structural or functional annotations
Type tissue
Description Refers to skeletal elements which are formed in cartilage and which later ossify. Also called replacement bone because it gradually replaces the pre-existing cartilage. (BRENDA Tissue and Enzyme Source Ontology, BTO_0002157)
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Genes

316 proteins co-occuring with the tissue endochondral bone in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.

Symbol Name Standardized Value
IHH indian hedgehog 2.43484
PTHLH parathyroid hormone-like hormone 2.14906
RUNX2 runt-related transcription factor 2 1.90291
SOX9 SRY (sex determining region Y)-box 9 1.85997
COL10A1 collagen, type X, alpha 1 1.85688
BMP3 bone morphogenetic protein 3 1.81941
BMP2 bone morphogenetic protein 2 1.71092
LECT1 leukocyte cell derived chemotaxin 1 1.67855
COL2A1 collagen, type II, alpha 1 1.67206
ACAN aggrecan 1.62058
PTH parathyroid hormone 1.56281
FGFR3 fibroblast growth factor receptor 3 1.48504
FOXI1 forkhead box I1 1.45704
BMP7 bone morphogenetic protein 7 1.43709
MMP13 matrix metallopeptidase 13 1.4103
ALPL alkaline phosphatase, liver/bone/kidney 1.39376
ALPPL2 alkaline phosphatase, placental-like 2 1.38002
ALPP alkaline phosphatase, placental 1.37819
BGLAP bone gamma-carboxyglutamate (gla) protein 1.30568
SP7 Sp7 transcription factor 1.30118
SOX3 SRY (sex determining region Y)-box 3 1.28053
TGFB1 transforming growth factor, beta 1 1.2662
LIN28A lin-28 homolog A (C. elegans) 1.18823
BMP4 bone morphogenetic protein 4 1.16737
COL9A2 collagen, type IX, alpha 2 1.13235
SPP1 secreted phosphoprotein 1 1.13058
PKDCC protein kinase domain containing, cytoplasmic 1.12084
BMP6 bone morphogenetic protein 6 1.11553
COL11A2P1 collagen, type XI, alpha 2 pseudogene 1 1.10225
PTH1R parathyroid hormone 1 receptor 1.09651
PTCH1 patched 1 1.07176
ACVR1 activin A receptor, type I 1.05149
FGF3 fibroblast growth factor 3 1.0462
EXT2 exostosin glycosyltransferase 2 1.04313
SIX1 SIX homeobox 1 1.02644
COL11A2 collagen, type XI, alpha 2 1.01331
SOX6 SRY (sex determining region Y)-box 6 1.00981
DYM dymeclin 1.00458
DSEL dermatan sulfate epimerase-like 0.9889
GDF2 growth differentiation factor 2 0.937059
EYA1 EYA transcriptional coactivator and phosphatase 1 0.928478
ECM1 extracellular matrix protein 1 0.923767
SOX5 SRY (sex determining region Y)-box 5 0.917779
EXT1 exostosin glycosyltransferase 1 0.916069
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.885862
HOXD4 homeobox D4 0.883321
FGF1 fibroblast growth factor 1 (acidic) 0.871905
SLC26A2 solute carrier family 26 (anion exchanger), member 2 0.86347
FGF8 fibroblast growth factor 8 (androgen-induced) 0.862627
ACPP acid phosphatase, prostate 0.853368
SHH sonic hedgehog 0.849585
DLX3 distal-less homeobox 3 0.847065
MMP9 matrix metallopeptidase 9 0.846225
LRR1 leucine rich repeat protein 1 0.840769
SIX4 SIX homeobox 4 0.820248
CBFB core-binding factor, beta subunit 0.816486
MSX1 msh homeobox 1 0.81565
PAX3 paired box 3 0.813144
IGF1 insulin-like growth factor 1 (somatomedin C) 0.808968
GLI3 GLI family zinc finger 3 0.808134
NOG noggin 0.806882
GLI1 GLI family zinc finger 1 0.800208
SMAD5 SMAD family member 5 0.798125
FOXI2 forkhead box I2 0.796041
COL27A1 collagen, type XXVII, alpha 1 0.794375
NEUROG2 neurogenin 2 0.77857
SMAD6 SMAD family member 6 0.774834
NPPC natriuretic peptide C 0.767783
WDR5 WD repeat domain 5 0.764054
TNMD tenomodulin 0.763226
PAX8 paired box 8 0.754124
LIN52 lin-52 DREAM MuvB core complex component 0.750818
PHOX2A paired-like homeobox 2a 0.745864
PAX2 paired box 2 0.745039
LIN37 lin-37 DREAM MuvB core complex component 0.739266
HOXA3 homeobox A3 0.734323
IBSP integrin-binding sialoprotein 0.71542
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.704764
GDF10 growth differentiation factor 10 0.703945
RPL31 ribosomal protein L31 0.702308
DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1 0.694946
BMP1 bone morphogenetic protein 1 0.691676
GLI2 GLI family zinc finger 2 0.683511
OGN osteoglycin 0.683103
LIN54 lin-54 DREAM MuvB core complex component 0.682695
NEUROG1 neurogenin 1 0.677395
FGFR2 fibroblast growth factor receptor 2 0.675357
COL9A1 collagen, type IX, alpha 1 0.665995
CDH7 cadherin 7, type 2 0.656242
RUNX3 runt-related transcription factor 3 0.649749
STC2 stanniocalcin 2 0.644479
CILP2 cartilage intermediate layer protein 2 0.644074
GNG12 guanine nucleotide binding protein (G protein), gamma 12 0.643263
TRAPPC2 trafficking protein particle complex 2 0.639619
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase 0.636785
MATN3 matrilin 3 0.631931
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 0.624658
CDH19 cadherin 19, type 2 0.620621
SMO smoothened, frizzled class receptor 0.619007
MSX2 msh homeobox 2 0.613764
COL1A1 collagen, type I, alpha 1 0.604502
NELL1 NEL-like 1 (chicken) 0.596862
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7 0.574416
FZD9 frizzled class receptor 9 0.57082
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 0.569622
FLT1 fms-related tyrosine kinase 1 0.569622
HOXA1 homeobox A1 0.569622
STOX1 storkhead box 1 0.567626
FKBP1C FK506 binding protein 1C 0.564434
MIA melanoma inhibitory activity 0.557661
EVC2 Ellis van Creveld syndrome 2 0.551298
VEGFA vascular endothelial growth factor A 0.54812
PRG4 proteoglycan 4 0.531089
MNX1 motor neuron and pancreas homeobox 1 0.530693
CHKB choline kinase beta 0.529508
PCNP PEST proteolytic signal containing nuclear protein 0.528719
SMAD7 SMAD family member 7 0.524771
BMP8B bone morphogenetic protein 8b 0.521617
SMAD9 SMAD family member 9 0.520435
HDAC4 histone deacetylase 4 0.517284
HAPLN1 hyaluronan and proteoglycan link protein 1 0.516891
NEUROD1 neuronal differentiation 1 0.513743
GOLM1 golgi membrane protein 1 0.500398
FRY furry homolog (Drosophila) 0.496483
MATN4 matrilin 4 0.492572
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 0.492182
GDF5 growth differentiation factor 5 0.489838
FOXN3 forkhead box N3 0.482817
BMP5 bone morphogenetic protein 5 0.469987
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.461465
HOXA2 homeobox A2 0.461078
MGP matrix Gla protein 0.452584
AXIN2 axin 2 0.450657
TGFB2 transforming growth factor, beta 2 0.445268
C11ORF58 chromosome 11 open reading frame 58 0.444115
ZBTB25 zinc finger and BTB domain containing 25 0.442578
EYA4 EYA transcriptional coactivator and phosphatase 4 0.439123
COMP cartilage oligomeric matrix protein 0.437589
ITM2A integral membrane protein 2A 0.437205
COL1A2 collagen, type I, alpha 2 0.436055
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 0.435289
NEO1 neogenin 1 0.434906
FGF22 fibroblast growth factor 22 0.43146
STC1 stanniocalcin 1 0.42993
SRY sex determining region Y 0.428783
DKK1 dickkopf WNT signaling pathway inhibitor 1 0.419623
KDR kinase insert domain receptor 0.416957
RUNX1 runt-related transcription factor 1 0.413151
DLX5 distal-less homeobox 5 0.412391
FGFR4 fibroblast growth factor receptor 4 0.405176
HOXB1 homeobox B1 0.399492
GLB1 galactosidase, beta 1 0.396087
FGF18 fibroblast growth factor 18 0.394197
TBX15 T-box 15 0.393442
IRX4 iroquois homeobox 4 0.391176
LOXL4 lysyl oxidase-like 4 0.38326
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 0.379123
MEF2C myocyte enhancer factor 2C 0.376119
DNPEP aspartyl aminopeptidase 0.376119
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 0.374618
COL9A3 collagen, type IX, alpha 3 0.370496
FN1 fibronectin 1 0.370496
PLAC8 placenta-specific 8 0.367876
SOST sclerostin 0.366007
ARID1B AT rich interactive domain 1B (SWI1-like) 0.364513
ANKH ANKH inorganic pyrophosphate transport regulator 0.361901
ACVR2A activin A receptor, type IIA 0.361155
LIN9 lin-9 DREAM MuvB core complex component 0.360409
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 0.355942
PRELP proline/arginine-rich end leucine-rich repeat protein 0.34371
CTSK cathepsin K 0.34334
ELMO1 engulfment and cell motility 1 0.340757
ARSE arylsulfatase E (chondrodysplasia punctata 1) 0.330827
ANGPTL7 angiopoietin-like 7 0.33046
CREB1 cAMP responsive element binding protein 1 0.328994
CDC34 cell division cycle 34 0.328994
FGFRL1 fibroblast growth factor receptor-like 1 0.323874
TBX3 T-box 3 0.323509
SOSTDC1 sclerostin domain containing 1 0.320227
CTGF connective tissue growth factor 0.316588
EVC Ellis van Creveld protein 0.316588
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.316224
OFD1 oral-facial-digital syndrome 1 0.315498
RPL29 ribosomal protein L29 0.314772
TGFB3 transforming growth factor, beta 3 0.314772
CASR calcium-sensing receptor 0.31187
FGF19 fibroblast growth factor 19 0.311507
CAMK1 calcium/calmodulin-dependent protein kinase I 0.304279
SOX13 SRY (sex determining region Y)-box 13 0.301398
GPC4 glypican 4 0.30032
FZD1 frizzled class receptor 1 0.29673
NFYB nuclear transcription factor Y, beta 0.29673
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) 0.296013
LRP5 low density lipoprotein receptor-related protein 5 0.294581
SHOX2 short stature homeobox 2 0.293866
FMOD fibromodulin 0.293866
DOCK5 dedicator of cytokinesis 5 0.292436
FRZB frizzled-related protein 0.291365
DLL1 delta-like 1 (Drosophila) 0.289939
RXRG retinoid X receptor, gamma 0.287803
EYA2 EYA transcriptional coactivator and phosphatase 2 0.284962
NPR2 natriuretic peptide receptor 2 0.28213
FGF2 fibroblast growth factor 2 (basic) 0.280717
HIST1H4A histone cluster 1, H4a 0.275444
HIST1H4E histone cluster 1, H4e 0.275444
HIST1H4F histone cluster 1, H4f 0.275444
HIST1H4D histone cluster 1, H4d 0.275444
HIST1H4C histone cluster 1, H4c 0.275444
HIST1H4K histone cluster 1, H4k 0.275444
HIST1H4B histone cluster 1, H4b 0.275444
HIST2H4B histone cluster 2, H4b 0.275444
HIST1H4J histone cluster 1, H4j 0.275444
HIST1H4H histone cluster 1, H4h 0.275444
HIST1H4I histone cluster 1, H4i 0.275444
HIST2H4A histone cluster 2, H4a 0.275094
SPON1 spondin 1, extracellular matrix protein 0.274394
HIST4H4 histone cluster 4, H4 0.274045
HIST1H4L histone cluster 1, H4l 0.274045
HSPG2 heparan sulfate proteoglycan 2 0.271256
SULF2 sulfatase 2 0.268482
RBBP4 retinoblastoma binding protein 4 0.265725
LIMK2 LIM domain kinase 2 0.262304
PRKG2 protein kinase, cGMP-dependent, type II 0.25457
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase 0.253578
FSTL1 follistatin-like 1 0.25259
HMGA2 high mobility group AT-hook 2 0.245807
SOX2 SRY (sex determining region Y)-box 2 0.24486
CHRD chordin 0.24486
FGFR1 fibroblast growth factor receptor 1 0.243918
WISP3 WNT1 inducible signaling pathway protein 3 0.243918
SUFU suppressor of fused homolog (Drosophila) 0.242983
COL6A3 collagen, type VI, alpha 3 0.23961
HNF4A hepatocyte nuclear factor 4, alpha 0.238706
GDF7 growth differentiation factor 7 0.237216
HDAC3 histone deacetylase 3 0.236921
LECT2 leukocyte cell-derived chemotaxin 2 0.236332
IFT88 intraflagellar transport 88 0.23459
FZD8 frizzled class receptor 8 0.230931
TRPS1 trichorhinophalangeal syndrome I 0.229568
PTPRG protein tyrosine phosphatase, receptor type, G 0.228497
BMPR1A bone morphogenetic protein receptor, type IA 0.22797
MT1E metallothionein 1E 0.227707
ACP5 acid phosphatase 5, tartrate resistant 0.224398
FZD10 frizzled class receptor 10 0.22415
VAMP8 vesicle-associated membrane protein 8 0.222938
ATF6 activating transcription factor 6 0.222224
PLXND1 plexin D1 0.220831
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3 0.220831
TWIST1 twist family bHLH transcription factor 1 0.21883
MMEL1 membrane metallo-endopeptidase-like 1 0.218186
HEBP1 heme binding protein 1 0.215341
HOXB5 homeobox B5 0.214576
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 0.209272
IMMT inner membrane protein, mitochondrial 0.203961
MYRF myelin regulatory factor 0.203745
HOXB4 homeobox B4 0.202625
FZD7 frizzled class receptor 7 0.198704
FZD2 frizzled class receptor 2 0.198586
METTL13 methyltransferase like 13 0.198169
ZIC1 Zic family member 1 0.19816
CES1 carboxylesterase 1 0.198107
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.198084
GMNN geminin, DNA replication inhibitor 0.19791
PITX2 paired-like homeodomain 2 0.197566
FZD4 frizzled class receptor 4 0.197532
TBX2 T-box 2 0.197067
GFRA1 GDNF family receptor alpha 1 0.197016
RET ret proto-oncogene 0.196627
PITX3 paired-like homeodomain 3 0.196368
PAX9 paired box 9 0.196336
TRPV1 transient receptor potential cation channel, subfamily V, member 1 0.196287
BTG2 BTG family, member 2 0.195886
GREM2 gremlin 2, DAN family BMP antagonist 0.195598
POU4F1 POU class 4 homeobox 1 0.195184
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) 0.195124
PAX6 paired box 6 0.19503
TOB1 transducer of ERBB2, 1 0.194868
NGF nerve growth factor (beta polypeptide) 0.194634
GATA3 GATA binding protein 3 0.194428
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.193262
EPHB3 EPH receptor B3 0.19122
EPHA2 EPH receptor A2 0.191198
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 0.191198
BDNF brain-derived neurotrophic factor 0.190779
EPHA4 EPH receptor A4 0.190741
SOX10 SRY (sex determining region Y)-box 10 0.190208
ADAM10 ADAM metallopeptidase domain 10 0.189713
TRPA1 transient receptor potential cation channel, subfamily A, member 1 0.189613
GDNF glial cell derived neurotrophic factor 0.188559
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase 0.183529
IGFBP1 insulin-like growth factor binding protein 1 0.182572
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1 0.181882
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 0.181735
PRKG1 protein kinase, cGMP-dependent, type I 0.181388
FIGF c-fos induced growth factor (vascular endothelial growth factor D) 0.181117
MYOD1 myogenic differentiation 1 0.180805
ASPH aspartate beta-hydroxylase 0.179264
FAT1 FAT atypical cadherin 1 0.178642
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.17833
NME3 NME/NM23 nucleoside diphosphate kinase 3 0.177285
NME4 NME/NM23 nucleoside diphosphate kinase 4 0.177263
G6PD glucose-6-phosphate dehydrogenase 0.177102
GADD45B growth arrest and DNA-damage-inducible, beta 0.176062
B3GAT1 beta-1,3-glucuronyltransferase 1 0.175512
HOXD9 homeobox D9 0.174104
NPR3 natriuretic peptide receptor 3 0.172351
CHAT choline O-acetyltransferase 0.170508
ASCL1 achaete-scute family bHLH transcription factor 1 0.168874
EDN1 endothelin 1 0.16718
DLK1 delta-like 1 homolog (Drosophila) 0.166816
FOXP2 forkhead box P2 0.164413
GATA2 GATA binding protein 2 0.164091
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.163953
IARS isoleucyl-tRNA synthetase 0.1633
MYB v-myb avian myeloblastosis viral oncogene homolog 0.161591
TYRO3 TYRO3 protein tyrosine kinase 0.161287