embryonic lethality between implantation and somite formation Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description death anytime between the point of implantation and somite formation (Mus: E4.5 to less than E8) (Mammalian Phenotype Ontology, MP_0006205)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0006205
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Genes

275 gene mutations causing the embryonic lethality between implantation and somite formation phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ACACA acetyl-CoA carboxylase alpha
ACLY ATP citrate lyase
ACVR1 activin A receptor, type I
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9
AGO2 argonaute RISC catalytic component 2
AHCTF1 AT hook containing transcription factor 1
AMD1 adenosylmethionine decarboxylase 1
AMOT angiomotin
ANAPC2 anaphase promoting complex subunit 2
APC adenomatous polyposis coli
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ARC activity-regulated cytoskeleton-associated protein
ARID1A AT rich interactive domain 1A (SWI-like)
ATOH8 atonal homolog 8 (Drosophila)
ATR ATR serine/threonine kinase
BARD1 BRCA1 associated RING domain 1
BECN1 beclin 1, autophagy related
BIRC5 baculoviral IAP repeat containing 5
BMP4 bone morphogenetic protein 4
BMPR1A bone morphogenetic protein receptor, type IA
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
BPTF bromodomain PHD finger transcription factor
BRCA1 breast cancer 1, early onset
BTF3 basic transcription factor 3
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
BUB3 BUB3 mitotic checkpoint protein
BYSL bystin-like
CAMLG calcium modulating ligand
CASC5 cancer susceptibility candidate 5
CCDC174 coiled-coil domain containing 174
CCNA2 cyclin A2
CDAN1 codanin 1
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC45 cell division cycle 45
CDC7 cell division cycle 7
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CDX2 caudal type homeobox 2
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CHEK1 checkpoint kinase 1
CHKA choline kinase alpha
CHMP4B charged multivesicular body protein 4B
CLNS1A chloride channel, nucleotide-sensitive, 1A
COPS2 COP9 signalosome subunit 2
COPS5 COP9 signalosome subunit 5
COPS6 COP9 signalosome subunit 6
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSNK2B casein kinase 2, beta polypeptide
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CUL1 cullin 1
CUL3 cullin 3
CXXC1 CXXC finger protein 1
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DAD1 defender against cell death 1
DGCR8 DGCR8 microprocessor complex subunit
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9
DICER1 dicer 1, ribonuclease type III
DLD dihydrolipoamide dehydrogenase
DMBT1 deleted in malignant brain tumors 1
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DPAGT1 dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha)
DSG2 desmoglein 2
DSP desmoplakin
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1
E4F1 E4F transcription factor 1
EGFR epidermal growth factor receptor
ELF5 E74-like factor 5 (ets domain transcription factor)
ELL elongation factor RNA polymerase II
ENO1 enolase 1, (alpha)
EOMES eomesodermin
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
EXT1 exostosin glycosyltransferase 1
EXT2 exostosin glycosyltransferase 2
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FBN1 fibrillin 1
FERMT2 fermitin family member 2
FGF4 fibroblast growth factor 4
FGFR1 fibroblast growth factor receptor 1
FGFR2 fibroblast growth factor receptor 2
FH fumarate hydratase
FLCN folliculin
FRS2 fibroblast growth factor receptor substrate 2
FXN frataxin
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GATA6 GATA binding protein 6
GCLC glutamate-cysteine ligase, catalytic subunit
GDF3 growth differentiation factor 3
GEMIN2 gem (nuclear organelle) associated protein 2
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS4 GINS complex subunit 4 (Sld5 homolog)
GJB3 gap junction protein, beta 3, 31kDa
GMNN geminin, DNA replication inhibitor
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GNPNAT1 glucosamine-phosphate N-acetyltransferase 1
GPX4 glutathione peroxidase 4
GRB2 growth factor receptor-bound protein 2
GUCY1B3 guanylate cyclase 1, soluble, beta 3
H2AFZ H2A histone family, member Z
HAND1 heart and neural crest derivatives expressed 1
HGS hepatocyte growth factor-regulated tyrosine kinase substrate
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HINFP histone H4 transcription factor
HNF1B HNF1 homeobox B
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2)
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
ILK integrin-linked kinase
INTS6 integrator complex subunit 6
IPO9 importin 9
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
KAT8 K(lysine) acetyltransferase 8
KDM1A lysine (K)-specific demethylase 1A
KIF11 kinesin family member 11
KITLG KIT ligand
KPNB1 karyopherin (importin) beta 1
LAMA1 laminin, alpha 1
LAMB1 laminin, beta 1
LAMC1 laminin, gamma 1 (formerly LAMB2)
LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
LIG3 ligase III, DNA, ATP-dependent
LIMS1 LIM and senescent cell antigen-like domains 1
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LTBP2 latent transforming growth factor beta binding protein 2
MACF1 microtubule-actin crosslinking factor 1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAPK1 mitogen-activated protein kinase 1
MAX MYC associated factor X
MBD3 methyl-CpG binding domain protein 3
MCM4 minichromosome maintenance complex component 4
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MDM4 MDM4, p53 regulator
MED12 mediator complex subunit 12
MET MET proto-oncogene, receptor tyrosine kinase
MNAT1 MNAT CDK-activating kinase assembly factor 1
MRC1 mannose receptor, C type 1
MST1R macrophage stimulating 1 receptor
MTBP MDM2 binding protein
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYH9 myosin, heavy chain 9, non-muscle
NANOG Nanog homeobox
NARFL nuclear prelamin A recognition factor-like
NBN nibrin
NCAPG2 non-SMC condensin II complex, subunit G2
NCDN neurochondrin
NDEL1 nudE neurodevelopment protein 1-like 1
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa
NELFB negative elongation factor complex member B
NF2 neurofibromin 2 (merlin)
NFE2L1 nuclear factor, erythroid 2-like 1
NLE1 notchless homolog 1 (Drosophila)
NMT1 N-myristoyltransferase 1
NODAL nodal growth differentiation factor
NR5A2 nuclear receptor subfamily 5, group A, member 2
NRBP1 nuclear receptor binding protein 1
NRF1 nuclear respiratory factor 1
NUP62 nucleoporin 62kDa
ODC1 ornithine decarboxylase 1
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PARG poly (ADP-ribose) glycohydrolase
PAX3 paired box 3
PAX6 paired box 6
PAXIP1 PAX interacting (with transcription-activation domain) protein 1
PCSK5 proprotein convertase subtilisin/kexin type 5
PELO pelota homolog (Drosophila)
PFAS phosphoribosylformylglycinamidine synthase
PFDN2 prefoldin subunit 2
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PGM3 phosphoglucomutase 3
PHB prohibitin
PHF5A PHD finger protein 5A
PITPNB phosphatidylinositol transfer protein, beta
PKNOX1 PBX/knotted 1 homeobox 1
PLK4 polo-like kinase 4
POFUT2 protein O-fucosyltransferase 2
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
POT1 protection of telomeres 1
POU5F1 POU class 5 homeobox 1
PPHLN1 periphilin 1
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PPP1R8 protein phosphatase 1, regulatory subunit 8
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PPP4C protein phosphatase 4, catalytic subunit
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PRMT1 protein arginine methyltransferase 1
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTBP1 polypyrimidine tract binding protein 1
PTEN phosphatase and tensin homolog
PTPMT1 protein tyrosine phosphatase, mitochondrial 1
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAD50 RAD50 homolog (S. cerevisiae)
RAD51 RAD51 recombinase
RAD51B RAD51 paralog B
RAD51C RAD51 paralog C
RAE1 ribonucleic acid export 1
RAI1 retinoic acid induced 1
RANGAP1 Ran GTPase activating protein 1
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1
RBBP6 retinoblastoma binding protein 6
RBX1 ring-box 1, E3 ubiquitin protein ligase
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit
RFK riboflavin kinase
RIC8A RIC8 guanine nucleotide exchange factor A
RINT1 RAD50 interactor 1
RPL38 ribosomal protein L38
RPTOR regulatory associated protein of MTOR, complex 1
RYBP RING1 and YY1 binding protein
SALL4 spalt-like transcription factor 4
SBDS Shwachman-Bodian-Diamond syndrome
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SETD1A SET domain containing 1A
SETDB1 SET domain, bifurcated 1
SIN3A SIN3 transcription regulator family member A
SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1
SMAD2 SMAD family member 2
SMAD4 SMAD family member 4
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
SMN1 survival of motor neuron 1, telomeric
SOX2 SRY (sex determining region Y)-box 2
SRRT serrate, RNA effector molecule
SRSF1 serine/arginine-rich splicing factor 1
SRSF2 serine/arginine-rich splicing factor 2
SSB Sjogren syndrome antigen B (autoantigen La)
SSRP1 structure specific recognition protein 1
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STX4 syntaxin 4
STXBP3 syntaxin binding protein 3
SUDS3 suppressor of defective silencing 3 homolog (S. cerevisiae)
T T, brachyury homolog (mouse)
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
TAL1 T-cell acute lymphocytic leukemia 1
TARDBP TAR DNA binding protein
TENM4 teneurin transmembrane protein 4
TERF1 telomeric repeat binding factor (NIMA-interacting) 1
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TGS1 trimethylguanosine synthase 1
THAP11 THAP domain containing 11
THOC5 THO complex 5
TIMELESS timeless circadian clock
TINF2 TERF1 (TRF1)-interacting nuclear factor 2
TJP2 tight junction protein 2
TLX2 T-cell leukemia homeobox 2
TOP3A topoisomerase (DNA) III alpha
TPI1 triosephosphate isomerase 1
TPT1 tumor protein, translationally-controlled 1
TRIM28 tripartite motif containing 28
TRIM33 tripartite motif containing 33
TRPM7 transient receptor potential cation channel, subfamily M, member 7
TSG101 tumor susceptibility 101
TSHZ2 teashirt zinc finger homeobox 2
TXN thioredoxin
UBA3 ubiquitin-like modifier activating enzyme 3
UBE2I ubiquitin-conjugating enzyme E2I
UBE2N ubiquitin-conjugating enzyme E2N
UPF1 UPF1 regulator of nonsense transcripts homolog (yeast)
UROD uroporphyrinogen decarboxylase
VAV1 vav 1 guanine nucleotide exchange factor
WDR1 WD repeat domain 1
WEE1 WEE1 G2 checkpoint kinase
ZNF24 zinc finger protein 24
ZNF281 zinc finger protein 281