embryonic growth retardation Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description slow or limited development during the embryonic period (sensu Mus: up to E14, or the completion of organogenesis) (Mammalian Phenotype Ontology, MP_0003984)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0003984
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Genes

408 gene mutations causing the embryonic growth retardation phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABI1 abl-interactor 1
ACACA acetyl-CoA carboxylase alpha
ACTB actin, beta
ACVRL1 activin A receptor type II-like 1
ADAR adenosine deaminase, RNA-specific
ADRBK1 adrenergic, beta, receptor kinase 1
AFF4 AF4/FMR2 family, member 4
AGO2 argonaute RISC catalytic component 2
AKAP13 A kinase (PRKA) anchor protein 13
ALAS1 5'-aminolevulinate synthase 1
ALPPL2 alkaline phosphatase, placental-like 2
ALX3 ALX homeobox 3
AMOT angiomotin
ANKRD17 ankyrin repeat domain 17
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APLP2 amyloid beta (A4) precursor-like protein 2
ARC activity-regulated cytoskeleton-associated protein
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ARNT aryl hydrocarbon receptor nuclear translocator
ASIP agouti signaling protein
ATAD3A ATPase family, AAA domain containing 3A
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
ATP11A ATPase, class VI, type 11A
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1
AURKA aurora kinase A
AXIN1 axin 1
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BCAR1 breast cancer anti-estrogen resistance 1
BLM Bloom syndrome, RecQ helicase-like
BMP4 bone morphogenetic protein 4
BMP8B bone morphogenetic protein 8b
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
BPTF bromodomain PHD finger transcription factor
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
BRD1 bromodomain containing 1
BRD2 bromodomain containing 2
BRD4 bromodomain containing 4
BRK1 BRICK1, SCAR/WAVE actin-nucleating complex subunit
BRWD3 bromodomain and WD repeat domain containing 3
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
C1GALT1C1 C1GALT1-specific chaperone 1
C1QBP complement component 1, q subcomponent binding protein
CCDC134 coiled-coil domain containing 134
CCM2 cerebral cavernous malformation 2
CDC25A cell division cycle 25A
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDH5 cadherin 5, type 2 (vascular endothelium)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CENPA centromere protein A
CENPC centromere protein C
CFLAR CASP8 and FADD-like apoptosis regulator
CHM choroideremia (Rab escort protein 1)
CHTOP chromatin target of PRMT1
CIR1 corepressor interacting with RBPJ, 1
COMMD1 copper metabolism (Murr1) domain containing 1
COPS3 COP9 signalosome subunit 3
COPS5 COP9 signalosome subunit 5
COPS8 COP9 signalosome subunit 8
COQ7 coenzyme Q7 homolog, ubiquinone (yeast)
CREBBP CREB binding protein
CSK c-src tyrosine kinase
CSNK2B casein kinase 2, beta polypeptide
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CUL4B cullin 4B
CXORF56 chromosome X open reading frame 56
CYCS cytochrome c, somatic
DAD1 defender against cell death 1
DAXX death-domain associated protein
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11
DERL1 derlin 1
DLC1 DLC1 Rho GTPase activating protein
DLD dihydrolipoamide dehydrogenase
DLL4 delta-like 4 (Drosophila)
DNM1L dynamin 1-like
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DOT1L DOT1-like histone H3K79 methyltransferase
DPH1 diphthamide biosynthesis 1
DPH3 diphthamide biosynthesis 3
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
E2F4 E2F transcription factor 4, p107/p130-binding
EFNB2 ephrin-B2
EHMT1 euchromatic histone-lysine N-methyltransferase 1
EIF3M eukaryotic translation initiation factor 3, subunit M
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2
ELAVL1 ELAV like RNA binding protein 1
ELF5 E74-like factor 5 (ets domain transcription factor)
ENG endoglin
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EP300 E1A binding protein p300
EPHB4 EPH receptor B4
ERCC1 excision repair cross-complementation group 1
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
ERN1 endoplasmic reticulum to nucleus signaling 1
ESRRB estrogen-related receptor beta
ETV2 ets variant 2
ETV6 ets variant 6
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
EZR ezrin
F2R coagulation factor II (thrombin) receptor
F3 coagulation factor III (thromboplastin, tissue factor)
FADD Fas (TNFRSF6)-associated via death domain
FANCA Fanconi anemia, complementation group A
FBXL5 F-box and leucine-rich repeat protein 5
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FBXW8 F-box and WD repeat domain containing 8
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FEN1 flap structure-specific endonuclease 1
FGF16 fibroblast growth factor 16
FGF3 fibroblast growth factor 3
FGFR1 fibroblast growth factor receptor 1
FGFR2 fibroblast growth factor receptor 2
FHOD3 formin homology 2 domain containing 3
FLRT3 fibronectin leucine rich transmembrane protein 3
FLT4 fms-related tyrosine kinase 4
FN1 fibronectin 1
FOLR1 folate receptor 1 (adult)
FOXH1 forkhead box H1
FOXO1 forkhead box O1
FRS2 fibroblast growth factor receptor substrate 2
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1
GATA4 GATA binding protein 4
GATA6 GATA binding protein 6
GCLC glutamate-cysteine ligase, catalytic subunit
GJB2 gap junction protein, beta 2, 26kDa
GJC1 gap junction protein, gamma 1, 45kDa
GLDC glycine dehydrogenase (decarboxylating)
GLI3 GLI family zinc finger 3
GLMN glomulin, FKBP associated protein
GLTSCR1L GLTSCR1-like
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GNPNAT1 glucosamine-phosphate N-acetyltransferase 1
GRB10 growth factor receptor-bound protein 10
GRHL2 grainyhead-like 2 (Drosophila)
GTF2I general transcription factor IIi
GTF2IRD1 GTF2I repeat domain containing 1
H3F3A H3 histone, family 3A
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
HAND1 heart and neural crest derivatives expressed 1
HAND2 heart and neural crest derivatives expressed 2
HAS2 hyaluronan synthase 2
HDAC1 histone deacetylase 1
HHEX hematopoietically expressed homeobox
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HIRA histone cell cycle regulator
HK2 hexokinase 2
HLA-DOA major histocompatibility complex, class II, DO alpha
HNF1B HNF1 homeobox B
HNF4A hepatocyte nuclear factor 4, alpha
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
HUS1 HUS1 checkpoint homolog (S. pombe)
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
IFT57 intraflagellar transport 57
IFT88 intraflagellar transport 88
IGF2 insulin-like growth factor 2
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
ILK integrin-linked kinase
IPMK inositol polyphosphate multikinase
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGAV integrin, alpha V
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITPK1 inositol-tetrakisphosphate 1-kinase
JAG1 jagged 1
JUN jun proto-oncogene
JUP junction plakoglobin
KAT2A K(lysine) acetyltransferase 2A
KAT7 K(lysine) acetyltransferase 7
KDM6A lysine (K)-specific demethylase 6A
KDM8 lysine (K)-specific demethylase 8
KIFAP3 kinesin-associated protein 3
KLF2 Kruppel-like factor 2
KLF8 Kruppel-like factor 8
KMT2B lysine (K)-specific methyltransferase 2B
KRAS Kirsten rat sarcoma viral oncogene homolog
LAMA1 laminin, alpha 1
LAMTOR2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
LATS2 large tumor suppressor kinase 2
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LIAS lipoic acid synthetase
LIG1 ligase I, DNA, ATP-dependent
LIG3 ligase III, DNA, ATP-dependent
LMNB1 lamin B1
LRP1 low density lipoprotein receptor-related protein 1
LRPPRC leucine-rich pentatricopeptide repeat containing
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK7 mitogen-activated protein kinase 7
MB myoglobin
MCM4 minichromosome maintenance complex component 4
MDFI MyoD family inhibitor
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MED1 mediator complex subunit 1
MED23 mediator complex subunit 23
MED31 mediator complex subunit 31
MEF2C myocyte enhancer factor 2C
MEN1 multiple endocrine neoplasia I
MESP1 mesoderm posterior basic helix-loop-helix transcription factor 1
MFN1 mitofusin 1
MGAT1 mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MIB1 mindbomb E3 ubiquitin protein ligase 1
MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae)
MPI mannose phosphate isomerase
MSX2 msh homeobox 2
MTERF3 mitochondrial transcription termination factor 3
MTFMT mitochondrial methionyl-tRNA formyltransferase
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MTTP microsomal triglyceride transfer protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
MYH9 myosin, heavy chain 9, non-muscle
MYL2 myosin, light chain 2, regulatory, cardiac, slow
MYL7 myosin, light chain 7, regulatory
MYOCD myocardin
NACA nascent polypeptide-associated complex alpha subunit
NCOA6 nuclear receptor coactivator 6
NCSTN nicastrin
NFE2L1 nuclear factor, erythroid 2-like 1
NKX2-5 NK2 homeobox 5
NOA1 nitric oxide associated 1
NOTCH1 notch 1
NOTCH2 notch 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NSDHL NAD(P) dependent steroid dehydrogenase-like
NUMB numb homolog (Drosophila)
NUP133 nucleoporin 133kDa
OPA1 optic atrophy 1 (autosomal dominant)
OTX2 orthodenticle homeobox 2
OVOL2 ovo-like zinc finger 2
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PARD3 par-3 family cell polarity regulator
PARVA parvin, alpha
PAXIP1 PAX interacting (with transcription-activation domain) protein 1
PDCD2 programmed cell death 2
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1
PDPK1 3-phosphoinositide dependent protein kinase 1
PEG10 paternally expressed 10
PELO pelota homolog (Drosophila)
PEPD peptidase D
PEX5 peroxisomal biogenesis factor 5
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIR pirin (iron-binding nuclear protein)
PKD1L1 polycystic kidney disease 1 like 1
PKNOX1 PBX/knotted 1 homeobox 1
PLCG1 phospholipase C, gamma 1
PLK2 polo-like kinase 2
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
PMM2 phosphomannomutase 2
PNN pinin, desmosome associated protein
PNPLA6 patatin-like phospholipase domain containing 6
POFUT1 protein O-fucosyltransferase 1
POGLUT1 protein O-glucosyltransferase 1
POLB polymerase (DNA directed), beta
POLG polymerase (DNA directed), gamma
POR P450 (cytochrome) oxidoreductase
PPAP2B phosphatidic acid phosphatase type 2B
PPARD peroxisome proliferator-activated receptor delta
PPARG peroxisome proliferator-activated receptor gamma
PRDM1 PR domain containing 1, with ZNF domain
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRKCI protein kinase C, iota
PROCR protein C receptor, endothelial
PSAT1 phosphoserine aminotransferase 1
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
PTEN phosphatase and tensin homolog
PTH1R parathyroid hormone 1 receptor
PTK2 protein tyrosine kinase 2
PTPMT1 protein tyrosine phosphatase, mitochondrial 1
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTPN23 protein tyrosine phosphatase, non-receptor type 23
PTPN9 protein tyrosine phosphatase, non-receptor type 9
PTPRB protein tyrosine phosphatase, receptor type, B
PTPRJ protein tyrosine phosphatase, receptor type, J
QKI QKI, KH domain containing, RNA binding
RAD51D RAD51 paralog D
RAD54L2 RAD54-like 2 (S. cerevisiae)
RAD9B RAD9 homolog B (S. pombe)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RASIP1 Ras interacting protein 1
RB1 retinoblastoma 1
RBBP6 retinoblastoma binding protein 6
RBM12 RNA binding motif protein 12
RBMS1 RNA binding motif, single stranded interacting protein 1
RBPJ recombination signal binding protein for immunoglobulin kappa J region
RDH10 retinol dehydrogenase 10 (all-trans)
REST RE1-silencing transcription factor
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit
RHEB Ras homolog enriched in brain
RICTOR RPTOR independent companion of MTOR, complex 2
RIF1 replication timing regulatory factor 1
RNASEH2B ribonuclease H2, subunit B
RNF7 ring finger protein 7
RPL29 ribosomal protein L29
RPL38 ribosomal protein L38
RPS7 ribosomal protein S7
RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)
RTEL1 regulator of telomere elongation helicase 1
RYBP RING1 and YY1 binding protein
RYR2 ryanodine receptor 2 (cardiac)
SECISBP2 SECIS binding protein 2
SETD1B SET domain containing 1B
SETD2 SET domain containing 2
SHH sonic hedgehog
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC25A26 solute carrier family 25 (S-adenosylmethionine carrier), member 26
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC39A1 solute carrier family 39 (zinc transporter), member 1
SLC39A2 solute carrier family 39 (zinc transporter), member 2
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1
SMAD2 SMAD family member 2
SMAD4 SMAD family member 4
SMAD5 SMAD family member 5
SMN1 survival of motor neuron 1, telomeric
SMO smoothened, frizzled class receptor
SMYD1 SET and MYND domain containing 1
SNAI1 snail family zinc finger 1
SOX17 SRY (sex determining region Y)-box 17
SOX7 SRY (sex determining region Y)-box 7
SP2 Sp2 transcription factor
SPINT1 serine peptidase inhibitor, Kunitz type 1
SPTAN1 spectrin, alpha, non-erythrocytic 1
SRF serum response factor (c-fos serum response element-binding transcription factor)
SS18 synovial sarcoma translocation, chromosome 18
STIL SCL/TAL1 interrupting locus
STK11 serine/threonine kinase 11
STX1A syntaxin 1A (brain)
SUFU suppressor of fused homolog (Drosophila)
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila)
T T, brachyury homolog (mouse)
TACC3 transforming, acidic coiled-coil containing protein 3
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
TAL1 T-cell acute lymphocytic leukemia 1
TBX20 T-box 20
TCEB3 transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A)
TCOF1 Treacher Collins-Franceschetti syndrome 1
TDG thymine-DNA glycosylase
TEK TEK tyrosine kinase, endothelial
TENM4 teneurin transmembrane protein 4
TET1 tet methylcytosine dioxygenase 1
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFDP1 transcription factor Dp-1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFRC transferrin receptor
TGFB1 transforming growth factor, beta 1
TGFBR1 transforming growth factor, beta receptor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGIF1 TGFB-induced factor homeobox 1
TMED2 transmembrane emp24 domain trafficking protein 2
TMEM100 transmembrane protein 100
TMOD1 tropomodulin 1
TNNT2 troponin T type 2 (cardiac)
TPT1 tumor protein, translationally-controlled 1
TRAIP TRAF interacting protein
TRIM28 tripartite motif containing 28
TRIM33 tripartite motif containing 33
TRIP12 thyroid hormone receptor interactor 12
TSC1 tuberous sclerosis 1
TSC2 tuberous sclerosis 2
TTBK2 tau tubulin kinase 2
TTN titin
UBE2L3 ubiquitin-conjugating enzyme E2L 3
UBP1 upstream binding protein 1 (LBP-1a)
UBR5 ubiquitin protein ligase E3 component n-recognin 5
UCHL5 ubiquitin carboxyl-terminal hydrolase L5
UGDH UDP-glucose 6-dehydrogenase
UHRF1 ubiquitin-like with PHD and ring finger domains 1
USP22 ubiquitin specific peptidase 22
USP8 ubiquitin specific peptidase 8
VCL vinculin
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
VPS26A vacuolar protein sorting 26 homolog A (S. pombe)
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae)
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae)
WASF2 WAS protein family, member 2
WASL Wiskott-Aldrich syndrome-like
WDR48 WD repeat domain 48
WNK1 WNK lysine deficient protein kinase 1
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
YBX1 Y box binding protein 1
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
ZBTB17 zinc finger and BTB domain containing 17
ZDHHC15 zinc finger, DHHC-type containing 15
ZFP36L1 ZFP36 ring finger protein-like 1
ZIC3 Zic family member 3
ZNF148 zinc finger protein 148