ellipticine-6253 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the ellipticine-6253 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTA1 actin, alpha 1, skeletal muscle
ACTA2 actin, alpha 2, smooth muscle, aorta
ADM adrenomedullin
APOA1 apolipoprotein A-I
APOE apolipoprotein E
ARC activity-regulated cytoskeleton-associated protein
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ATF3 activating transcription factor 3
C7ORF43 chromosome 7 open reading frame 43
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated
CACYBP calcyclin binding protein
CCKAR cholecystokinin A receptor
CCND2 cyclin D2
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
COL14A1 collagen, type XIV, alpha 1
CSRP2 cysteine and glycine-rich protein 2
CTGF connective tissue growth factor
CXCR4 chemokine (C-X-C motif) receptor 4
CYLD cylindromatosis (turban tumor syndrome)
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DLX2 distal-less homeobox 2
DOC2B double C2-like domains, beta
DUSP4 dual specificity phosphatase 4
EFHD1 EF-hand domain family, member D1
EGR1 early growth response 1
ERO1LB ERO1-like beta (S. cerevisiae)
FAM46C family with sequence similarity 46, member C
FGF18 fibroblast growth factor 18
FGF3 fibroblast growth factor 3
FH fumarate hydratase
FSCN1 fascin actin-bundling protein 1
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GLS glutaminase
H3F3B H3 histone, family 3B (H3.3B)
HBEGF heparin-binding EGF-like growth factor
HEXIM1 hexamethylene bis-acetamide inducible 1
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IDI2-AS1 IDI2 antisense RNA 1
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
IRS2 insulin receptor substrate 2
ITPK1 inositol-tetrakisphosphate 1-kinase
KLF9 Kruppel-like factor 9
LOC399491
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP2K2 mitogen-activated protein kinase kinase 2
MAP4 microtubule-associated protein 4
MED14 mediator complex subunit 14
METTL7A methyltransferase like 7A
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSX1 msh homeobox 1
MTA1 metastasis associated 1
MTSS1 metastasis suppressor 1
NF2 neurofibromin 2 (merlin)
NHLH2 nescient helix loop helix 2
NIPAL2 NIPA-like domain containing 2
NPTX1 neuronal pentraxin I
NR4A2 nuclear receptor subfamily 4, group A, member 2
NSUN6 NOP2/Sun domain family, member 6
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
ONECUT2 one cut homeobox 2
OR2B6 olfactory receptor, family 2, subfamily B, member 6
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDE4A phosphodiesterase 4A, cAMP-specific
PDE4DIP phosphodiesterase 4D interacting protein
PDK2 pyruvate dehydrogenase kinase, isozyme 2
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLEK pleckstrin
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma
PPT2 palmitoyl-protein thioesterase 2
PTMS parathymosin
PTRF polymerase I and transcript release factor
RCE1 Ras converting CAAX endopeptidase 1
RGCC regulator of cell cycle
RUFY3 RUN and FYVE domain containing 3
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SGK1 serum/glucocorticoid regulated kinase 1
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC35A2 solute carrier family 35 (UDP-galactose transporter), member A2
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOX9 SRY (sex determining region Y)-box 9
SUGP1 SURP and G patch domain containing 1
SUMO1 small ubiquitin-like modifier 1
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TAT tyrosine aminotransferase
TOX4 TOX high mobility group box family member 4
TTC33 tetratricopeptide repeat domain 33
VAX2 ventral anterior homeobox 2
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1
ZCCHC24 zinc finger, CCHC domain containing 24

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ADNP activity-dependent neuroprotector homeobox
AMIGO2 adhesion molecule with Ig-like domain 2
ARID5B AT rich interactive domain 5B (MRF1-like)
ARMC7 armadillo repeat containing 7
ARMCX1 armadillo repeat containing, X-linked 1
ARMCX5 armadillo repeat containing, X-linked 5
ATF4 activating transcription factor 4
BANP BTG3 associated nuclear protein
BCAR3 breast cancer anti-estrogen resistance 3
BYSL bystin-like
C17ORF62 chromosome 17 open reading frame 62
C5ORF30 chromosome 5 open reading frame 30
C7ORF49 chromosome 7 open reading frame 49
CCNL1 cyclin L1
CDCA4 cell division cycle associated 4
CENPE centromere protein E, 312kDa
CLDN4 claudin 4
COA7 cytochrome c oxidase assembly factor 7 (putative)
COIL coilin
CROCCP2 ciliary rootlet coiled-coil, rootletin pseudogene 2
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
DET1 de-etiolated homolog 1 (Arabidopsis)
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
E2F6 E2F transcription factor 6
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EFNA4 ephrin-A4
ERCC6L excision repair cross-complementation group 6-like
FADD Fas (TNFRSF6)-associated via death domain
FAM50B family with sequence similarity 50, member B
FBXO34 F-box protein 34
FOXA1 forkhead box A1
GTF2H2B general transcription factor IIH, polypeptide 2B (pseudogene)
HAUS3 HAUS augmin-like complex, subunit 3
HILPDA hypoxia inducible lipid droplet-associated
HJURP Holliday junction recognition protein
HOXC6 homeobox C6
HSPA8 heat shock 70kDa protein 8
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IFRD1 interferon-related developmental regulator 1
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
LOC100272216 uncharacterized LOC100272216
MCRS1 microspherule protein 1
MPHOSPH10 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)
MSL1 male-specific lethal 1 homolog (Drosophila)
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAA40 N(alpha)-acetyltransferase 40, NatD catalytic subunit
NCK1 NCK adaptor protein 1
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
PGS1 phosphatidylglycerophosphate synthase 1
PLK2 polo-like kinase 2
PNRC2 proline-rich nuclear receptor coactivator 2
POLD3 polymerase (DNA-directed), delta 3, accessory subunit
PPAN peter pan homolog (Drosophila)
PPP1R8 protein phosphatase 1, regulatory subunit 8
PRKRIP1 PRKR interacting protein 1 (IL11 inducible)
PRR15L proline rich 15-like
RANBP6 RAN binding protein 6
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RBM4B RNA binding motif protein 4B
RHOB ras homolog family member B
RIOK2 RIO kinase 2
RPP38 ribonuclease P/MRP 38kDa subunit
SCAF8 SR-related CTD-associated factor 8
SLBP stem-loop binding protein
SLC38A2 solute carrier family 38, member 2
SNRNP35 small nuclear ribonucleoprotein 35kDa (U11/U12)
SPATA2L spermatogenesis associated 2-like
SPECC1L sperm antigen with calponin homology and coiled-coil domains 1-like
STARD7 StAR-related lipid transfer (START) domain containing 7
STC2 stanniocalcin 2
TAF7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa
TBK1 TANK-binding kinase 1
TGS1 trimethylguanosine synthase 1
THEM6 thioesterase superfamily member 6
TMEM186 transmembrane protein 186
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TOB1 transducer of ERBB2, 1
TRIM13 tripartite motif containing 13
TRIM32 tripartite motif containing 32
TSKU tsukushi, small leucine rich proteoglycan
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
USP21 ubiquitin specific peptidase 21
WDR5B WD repeat domain 5B
XBP1 X-box binding protein 1
ZBED5 zinc finger, BED-type containing 5
ZBTB24 zinc finger and BTB domain containing 24
ZCCHC2 zinc finger, CCHC domain containing 2
ZIC1 Zic family member 1
ZNF107 zinc finger protein 107
ZNF146 zinc finger protein 146
ZNF232 zinc finger protein 232
ZNF443 zinc finger protein 443
ZNF587 zinc finger protein 587
ZNF85 zinc finger protein 85
ZSCAN16 zinc finger and SCAN domain containing 16