edrophonium chloride-6655 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the edrophonium chloride-6655 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACSBG2 acyl-CoA synthetase bubblegum family member 2
ADAM28 ADAM metallopeptidase domain 28
ADARB1 adenosine deaminase, RNA-specific, B1
ADCY9 adenylate cyclase 9
AFF2 AF4/FMR2 family, member 2
AKR1D1 aldo-keto reductase family 1, member D1
AP2A2 adaptor-related protein complex 2, alpha 2 subunit
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BTNL3 butyrophilin-like 3
C1ORF61 chromosome 1 open reading frame 61
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CERS4 ceramide synthase 4
CFLAR CASP8 and FADD-like apoptosis regulator
CLCN6 chloride channel, voltage-sensitive 6
CLEC4E C-type lectin domain family 4, member E
CLUL1 clusterin-like 1 (retinal)
CNPY4 canopy FGF signaling regulator 4
CYTH3 cytohesin 3
DBF4B DBF4 zinc finger B
DDR1-AS1 DDR1 antisense RNA 1 (head to head)
DMP1 dentin matrix acidic phosphoprotein 1
DOCK10 dedicator of cytokinesis 10
DST dystonin
EPHB1 EPH receptor B1
ESR1 estrogen receptor 1
FAM135A family with sequence similarity 135, member A
FGFR2 fibroblast growth factor receptor 2
FLOT1 flotillin 1
FLRT2 fibronectin leucine rich transmembrane protein 2
FXYD2 FXYD domain containing ion transport regulator 2
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GINS4 GINS complex subunit 4 (Sld5 homolog)
GMPR guanosine monophosphate reductase
GP1BA glycoprotein Ib (platelet), alpha polypeptide
GPLD1 glycosylphosphatidylinositol specific phospholipase D1
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HABP4 hyaluronan binding protein 4
HLA-DOA major histocompatibility complex, class II, DO alpha
HOXB6 homeobox B6
HRASLS2 HRAS-like suppressor 2
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
ICAM1 intercellular adhesion molecule 1
ICOSLG inducible T-cell co-stimulator ligand
IFNA16 interferon, alpha 16
IFNA17 interferon, alpha 17
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
ING4 inhibitor of growth family, member 4
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
KAT8 K(lysine) acetyltransferase 8
KIF25-AS1 KIF25 antisense RNA 1
KLF12 Kruppel-like factor 12
KLF13 Kruppel-like factor 13
LEFTY2 left-right determination factor 2
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1
LRRC37A3 leucine rich repeat containing 37, member A3
MAGEA1 melanoma antigen family A1
MEG3 maternally expressed 3 (non-protein coding)
MLANA melan-A
MOG myelin oligodendrocyte glycoprotein
MST1L macrophage stimulating 1-like
NF1 neurofibromin 1
NKAIN1 Na+/K+ transporting ATPase interacting 1
NPPB natriuretic peptide B
OXCT2 3-oxoacid CoA transferase 2
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PCDH17 protocadherin 17
PCDHA5 protocadherin alpha 5
PCDHGB5 protocadherin gamma subfamily B, 5
PDLIM5 PDZ and LIM domain 5
PENK proenkephalin
PHOX2A paired-like homeobox 2a
PRDM2 PR domain containing 2, with ZNF domain
PRKCE protein kinase C, epsilon
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2
RABGAP1 RAB GTPase activating protein 1
RPL35A ribosomal protein L35a
SLA Src-like-adaptor
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC45A2 solute carrier family 45, member 2
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
SPAG6 sperm associated antigen 6
SPHK2 sphingosine kinase 2
STX2 syntaxin 2
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
THOC5 THO complex 5
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1
TRIM31 tripartite motif containing 31
TUBA3C tubulin, alpha 3c
TYRP1 tyrosinase-related protein 1
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZNF778 zinc finger protein 778
ZSCAN32 zinc finger and SCAN domain containing 32

decreased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ADGRG2 adhesion G protein-coupled receptor G2
AFAP1 actin filament associated protein 1
AFF4 AF4/FMR2 family, member 4
AGO4 argonaute RISC catalytic component 4
APOLD1 apolipoprotein L domain containing 1
ARHGAP10 Rho GTPase activating protein 10
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ARMCX2 armadillo repeat containing, X-linked 2
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
BBC3 BCL2 binding component 3
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2
C7ORF69 chromosome 7 open reading frame 69
CA9 carbonic anhydrase IX
CD82 CD82 molecule
CDKL3 cyclin-dependent kinase-like 3
CEP72 centrosomal protein 72kDa
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CLEC2B C-type lectin domain family 2, member B
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CNGA1 cyclic nucleotide gated channel alpha 1
CNGB3 cyclic nucleotide gated channel beta 3
CPNE7 copine VII
CST1 cystatin SN
CXCL3 chemokine (C-X-C motif) ligand 3
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
DHODH dihydroorotate dehydrogenase (quinone)
DLK2 delta-like 2 homolog (Drosophila)
DTX2 deltex 2, E3 ubiquitin ligase
ECM1 extracellular matrix protein 1
FGF23 fibroblast growth factor 23
FMO4 flavin containing monooxygenase 4
FRS3 fibroblast growth factor receptor substrate 3
FSTL3 follistatin-like 3 (secreted glycoprotein)
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
HAMP hepcidin antimicrobial peptide
HIRIP3 HIRA interacting protein 3
HIST1H2AK histone cluster 1, H2ak
HMOX1 heme oxygenase 1
HOMER2 homer scaffolding protein 2
KDM5C lysine (K)-specific demethylase 5C
KIAA1456 KIAA1456
LAMC3 laminin, gamma 3
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LOC730101 uncharacterized LOC730101
LY6G6C lymphocyte antigen 6 complex, locus G6C
LY96 lymphocyte antigen 96
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MCTP2 multiple C2 domains, transmembrane 2
MED31 mediator complex subunit 31
MILR1 mast cell immunoglobulin-like receptor 1
NACA2 nascent polypeptide-associated complex alpha subunit 2
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin)
NRTN neurturin
OSBP2 oxysterol binding protein 2
OVGP1 oviductal glycoprotein 1, 120kDa
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z
PROL1 proline rich, lacrimal 1
PTK6 protein tyrosine kinase 6
RAB3A RAB3A, member RAS oncogene family
RABL6 RAB, member RAS oncogene family-like 6
RIN1 Ras and Rab interactor 1
RPRM reprimo, TP53 dependent G2 arrest mediator candidate
RWDD2A RWD domain containing 2A
S100A3 S100 calcium binding protein A3
SIX3 SIX homeobox 3
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC39A7 solute carrier family 39 (zinc transporter), member 7
SLC4A3 solute carrier family 4 (anion exchanger), member 3
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SPATA1 spermatogenesis associated 1
SPTBN2 spectrin, beta, non-erythrocytic 2
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TCTN2 tectonic family member 2
TENM1 teneurin transmembrane protein 1
TGFBI transforming growth factor, beta-induced, 68kDa
TLR2 toll-like receptor 2
TMEM180 transmembrane protein 180
TRAF2 TNF receptor-associated factor 2
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TXLNG taxilin gamma
USP18 ubiquitin specific peptidase 18
USP27X ubiquitin specific peptidase 27, X-linked
VGF VGF nerve growth factor inducible
VWA1 von Willebrand factor A domain containing 1
WDR18 WD repeat domain 18
ZBTB6 zinc finger and BTB domain containing 6
ZNF219 zinc finger protein 219
ZNF442 zinc finger protein 442
ZNF675 zinc finger protein 675
ZW10 zw10 kinetochore protein