edrophonium chloride-5001 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the edrophonium chloride-5001 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A4GNT alpha-1,4-N-acetylglucosaminyltransferase
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ADAM22 ADAM metallopeptidase domain 22
ALOX12 arachidonate 12-lipoxygenase
ALOX5 arachidonate 5-lipoxygenase
ARHGAP26 Rho GTPase activating protein 26
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4
ARPIN actin-related protein 2/3 complex inhibitor
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
ATP9A ATPase, class II, type 9A
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BICD1 bicaudal D homolog 1 (Drosophila)
BMP15 bone morphogenetic protein 15
CAPN9 calpain 9
CCL27 chemokine (C-C motif) ligand 27
CD53 CD53 molecule
CDC14B cell division cycle 14B
CLCA2 chloride channel accessory 2
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
DMP1 dentin matrix acidic phosphoprotein 1
DUSP13 dual specificity phosphatase 13
EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2
ELN elastin
EPHB2 EPH receptor B2
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
FABP3 fatty acid binding protein 3, muscle and heart
FKBP10 FK506 binding protein 10, 65 kDa
FLI1 Fli-1 proto-oncogene, ETS transcription factor
GBP1 guanylate binding protein 1, interferon-inducible
GPR143 G protein-coupled receptor 143
GRIK5 glutamate receptor, ionotropic, kainate 5
GRM6 glutamate receptor, metabotropic 6
HFE hemochromatosis
HNF1A HNF1 homeobox A
HR hair growth associated
IL2 interleukin 2
ING1 inhibitor of growth family, member 1
ING2 inhibitor of growth family, member 2
INHBA inhibin, beta A
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
KCNK5 potassium channel, two pore domain subfamily K, member 5
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3
KIAA1109 KIAA1109
KIR2DL4 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4
KRT24 keratin 24, type I
KRT6B keratin 6B, type II
LMF2 lipase maturation factor 2
MAST3 microtubule associated serine/threonine kinase 3
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MORC1 MORC family CW-type zinc finger 1
MX1 MX dynamin-like GTPase 1
MYH14 myosin, heavy chain 14, non-muscle
MYRIP myosin VIIA and Rab interacting protein
NCOR2 nuclear receptor corepressor 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NF1 neurofibromin 1
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NOX3 NADPH oxidase 3
NOX5 NADPH oxidase, EF-hand calcium binding domain 5
NR2E3 nuclear receptor subfamily 2, group E, member 3
NRP1 neuropilin 1
OGFR opioid growth factor receptor
OTOR otoraplin
PAX5 paired box 5
PCSK5 proprotein convertase subtilisin/kexin type 5
PDGFD platelet derived growth factor D
PDHA2 pyruvate dehydrogenase (lipoamide) alpha 2
PDLIM3 PDZ and LIM domain 3
PGLYRP4 peptidoglycan recognition protein 4
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PKNOX2 PBX/knotted 1 homeobox 2
PLSCR4 phospholipid scramblase 4
PON3 paraoxonase 3
RBM48 RNA binding motif protein 48
RPS4Y1 ribosomal protein S4, Y-linked 1
RRBP1 ribosome binding protein 1
RUNX1 runt-related transcription factor 1
S100A8 S100 calcium binding protein A8
SLC22A14 solute carrier family 22, member 14
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37
SLC30A3 solute carrier family 30 (zinc transporter), member 3
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SNAP25 synaptosomal-associated protein, 25kDa
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
SPHK2 sphingosine kinase 2
ST8SIA3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
TCP11L1 t-complex 11, testis-specific-like 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
THSD4 thrombospondin, type I, domain containing 4
TSHR thyroid stimulating hormone receptor
UNC119 unc-119 homolog (C. elegans)
WNT16 wingless-type MMTV integration site family, member 16
WSCD1 WSC domain containing 1
XAF1 XIAP associated factor 1
ZFHX2 zinc finger homeobox 2
ZNF749 zinc finger protein 749

decreased expression

Symbol Name
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
AP1B1 adaptor-related protein complex 1, beta 1 subunit
AP1G2 adaptor-related protein complex 1, gamma 2 subunit
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ARRB1 arrestin, beta 1
ASPHD1 aspartate beta-hydroxylase domain containing 1
BAG4 BCL2-associated athanogene 4
BCL9 B-cell CLL/lymphoma 9
C1ORF35 chromosome 1 open reading frame 35
C2ORF54 chromosome 2 open reading frame 54
CAPN15 calpain 15
CASP3 caspase 3, apoptosis-related cysteine peptidase
CHRM3 cholinergic receptor, muscarinic 3
CLCN5 chloride channel, voltage-sensitive 5
CPPED1 calcineurin-like phosphoesterase domain containing 1
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
ECHDC3 enoyl CoA hydratase domain containing 3
ENO2 enolase 2 (gamma, neuronal)
ERMAP erythroblast membrane-associated protein (Scianna blood group)
ETAA1 Ewing tumor-associated antigen 1
FAM110B family with sequence similarity 110, member B
FKBP5 FK506 binding protein 5
FSTL3 follistatin-like 3 (secreted glycoprotein)
GBP2 guanylate binding protein 2, interferon-inducible
GLB1L2 galactosidase, beta 1-like 2
GLS2 glutaminase 2 (liver, mitochondrial)
GRAMD4 GRAM domain containing 4
GUF1 GUF1 GTPase homolog (S. cerevisiae)
HYAL2 hyaluronoglucosaminidase 2
IFNAR1 interferon (alpha, beta and omega) receptor 1
INO80D INO80 complex subunit D
JMJD4 jumonji domain containing 4
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KIAA0319L KIAA0319-like
LMBR1L limb development membrane protein 1-like
LRP5 low density lipoprotein receptor-related protein 5
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1
MALL mal, T-cell differentiation protein-like
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAPK12 mitogen-activated protein kinase 12
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MTA2 metastasis associated 1 family, member 2
MYO9A myosin IXA
NME5 NME/NM23 family member 5
NRGN neurogranin (protein kinase C substrate, RC3)
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
P3H1 prolyl 3-hydroxylase 1
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PHC1 polyhomeotic homolog 1 (Drosophila)
PLA2G15 phospholipase A2, group XV
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLD3 phospholipase D family, member 3
PNPLA6 patatin-like phospholipase domain containing 6
POLH polymerase (DNA directed), eta
POMT2 protein-O-mannosyltransferase 2
PRF1 perforin 1 (pore forming protein)
PYCRL pyrroline-5-carboxylate reductase-like
RAB3A RAB3A, member RAS oncogene family
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RPH3AL rabphilin 3A-like (without C2 domains)
RWDD3 RWD domain containing 3
S100A9 S100 calcium binding protein A9
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SLMO1 slowmo homolog 1 (Drosophila)
SLN sarcolipin
SPRY2 sprouty homolog 2 (Drosophila)
STAG3L1 stromal antigen 3-like 1 (pseudogene)
STX1A syntaxin 1A (brain)
SYCP2 synaptonemal complex protein 2
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
THAP1 THAP domain containing, apoptosis associated protein 1
THBS3 thrombospondin 3
TMEM132A transmembrane protein 132A
TMEM254 transmembrane protein 254
TMPRSS3 transmembrane protease, serine 3
TRABD TraB domain containing
TRAF2 TNF receptor-associated factor 2
TRIM21 tripartite motif containing 21
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene)
ULBP2 UL16 binding protein 2
VGF VGF nerve growth factor inducible
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae)
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZC3H12A zinc finger CCCH-type containing 12A
ZNF134 zinc finger protein 134
ZNF141 zinc finger protein 141
ZNF211 zinc finger protein 211
ZNF329 zinc finger protein 329
ZNF442 zinc finger protein 442
ZNF580 zinc finger protein 580
ZNF639 zinc finger protein 639
ZNF767P zinc finger family member 767, pseudogene
ZNF862 zinc finger protein 862