edrophonium chloride-2019 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the edrophonium chloride-2019 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD3 abhydrolase domain containing 3
ACAN aggrecan
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10
ARL1 ADP-ribosylation factor-like 1
ARL4C ADP-ribosylation factor-like 4C
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1
BCR breakpoint cluster region
C16ORF58 chromosome 16 open reading frame 58
C20ORF27 chromosome 20 open reading frame 27
C22ORF24 chromosome 22 open reading frame 24
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCDC94 coiled-coil domain containing 94
CDADC1 cytidine and dCMP deaminase domain containing 1
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDV3 CDV3 homolog (mouse)
CHD1L chromodomain helicase DNA binding protein 1-like
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLTCL1 clathrin, heavy chain-like 1
CORO7 coronin 7
CPNE7 copine VII
CTRC chymotrypsin C (caldecrin)
CUBN cubilin (intrinsic factor-cobalamin receptor)
CYBRD1 cytochrome b reductase 1
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DRD2 dopamine receptor D2
ELMO2 engulfment and cell motility 2
ERCC8 excision repair cross-complementation group 8
FAM3A family with sequence similarity 3, member A
FCAR Fc fragment of IgA receptor
FLJ10038 uncharacterized protein FLJ10038
GOLM1 golgi membrane protein 1
HIST1H2AJ histone cluster 1, H2aj
HP1BP3 heterochromatin protein 1, binding protein 3
IFNA17 interferon, alpha 17
INHA inhibin, alpha
IRAK3 interleukin-1 receptor-associated kinase 3
KLF6 Kruppel-like factor 6
KLHL18 kelch-like family member 18
KLK8 kallikrein-related peptidase 8
LAMP5 lysosomal-associated membrane protein family, member 5
LDHC lactate dehydrogenase C
LENEP lens epithelial protein
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
LTB lymphotoxin beta (TNF superfamily, member 3)
LTB4R leukotriene B4 receptor
MAPK1 mitogen-activated protein kinase 1
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MCL1 myeloid cell leukemia 1
MED13L mediator complex subunit 13-like
MED20 mediator complex subunit 20
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
MVK mevalonate kinase
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)
NPEPL1 aminopeptidase-like 1
NR1D2 nuclear receptor subfamily 1, group D, member 2
NTRK3 neurotrophic tyrosine kinase, receptor, type 3
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6
OCRL oculocerebrorenal syndrome of Lowe
OR2C1 olfactory receptor, family 2, subfamily C, member 1
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa
PDZD7 PDZ domain containing 7
PICALM phosphatidylinositol binding clathrin assembly protein
PIDD1 p53-induced death domain protein 1
PLS1 plastin 1
PPP1R7 protein phosphatase 1, regulatory subunit 7
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PTDSS2 phosphatidylserine synthase 2
RALGAPB Ral GTPase activating protein, beta subunit (non-catalytic)
REC8 REC8 meiotic recombination protein
RNF144A ring finger protein 144A
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RUNDC3A RUN domain containing 3A
RUNX1 runt-related transcription factor 1
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
SENP3 SUMO1/sentrin/SMT3 specific peptidase 3
SH3BP2 SH3-domain binding protein 2
SMC4 structural maintenance of chromosomes 4
SMEK1 SMEK homolog 1, suppressor of mek1 (Dictyostelium)
SMO smoothened, frizzled class receptor
SPDEF SAM pointed domain containing ETS transcription factor
SRGN serglycin
SSSCA1 Sjogren syndrome/scleroderma autoantigen 1
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
SYMPK symplekin
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TERT telomerase reverse transcriptase
THRB thyroid hormone receptor, beta
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TRABD TraB domain containing
TRMT61A tRNA methyltransferase 61A
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
WNT10B wingless-type MMTV integration site family, member 10B
ZNF224 zinc finger protein 224
ZSCAN26 zinc finger and SCAN domain containing 26

decreased expression

Symbol Name
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
ADRB2 adrenoceptor beta 2, surface
AP1B1 adaptor-related protein complex 1, beta 1 subunit
APEX2 APEX nuclease (apurinic/apyrimidinic endonuclease) 2
AZI2 5-azacytidine induced 2
BAHD1 bromo adjacent homology domain containing 1
C11ORF68 chromosome 11 open reading frame 68
C12ORF29 chromosome 12 open reading frame 29
C19ORF40 chromosome 19 open reading frame 40
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
C6ORF47 chromosome 6 open reading frame 47
CD302 CD302 molecule
CDCA8 cell division cycle associated 8
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CLEC16A C-type lectin domain family 16, member A
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase
COMMD8 COMM domain containing 8
CPOX coproporphyrinogen oxidase
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
CTBS chitobiase, di-N-acetyl-
DCP2 decapping mRNA 2
DENND4A DENN/MADD domain containing 4A
DMTF1 cyclin D binding myb-like transcription factor 1
DPF3 D4, zinc and double PHD fingers, family 3
DPYD dihydropyrimidine dehydrogenase
EMD emerin
EPM2AIP1 EPM2A (laforin) interacting protein 1
ERBB2IP erbb2 interacting protein
FHL3 four and a half LIM domains 3
FTH1P5 ferritin, heavy polypeptide 1 pseudogene 5
FTO fat mass and obesity associated
FUCA1 fucosidase, alpha-L- 1, tissue
GDI1 GDP dissociation inhibitor 1
GIMAP6 GTPase, IMAP family member 6
GMCL1 germ cell-less, spermatogenesis associated 1
GTF2IRD1 GTF2I repeat domain containing 1
GUSBP3 glucuronidase, beta pseudogene 3
HACD2 3-hydroxyacyl-CoA dehydratase 2
HIRA histone cell cycle regulator
IL2RG interleukin 2 receptor, gamma
IL4R interleukin 4 receptor
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KIF3B kinesin family member 3B
KRCC1 lysine-rich coiled-coil 1
KRT38 keratin 38, type I
LEMD3 LEM domain containing 3
LSP1 lymphocyte-specific protein 1
LZTR1 leucine-zipper-like transcription regulator 1
MAML1 mastermind-like 1 (Drosophila)
MARCKSL1 MARCKS-like 1
MCTP1 multiple C2 domains, transmembrane 1
MEPCE methylphosphate capping enzyme
METTL18 methyltransferase like 18
METTL21B methyltransferase like 21B
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
NACAP1 nascent-polypeptide-associated complex alpha polypeptide pseudogene 1
NFE2L2 nuclear factor, erythroid 2-like 2
OAT ornithine aminotransferase
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)
PAN2 PAN2 poly(A) specific ribonuclease subunit
PAQR3 progestin and adipoQ receptor family member III
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1
PEX12 peroxisomal biogenesis factor 12
PEX26 peroxisomal biogenesis factor 26
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PPIP5K2 diphosphoinositol pentakisphosphate kinase 2
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
RAP1A RAP1A, member of RAS oncogene family
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RPRD1A regulation of nuclear pre-mRNA domain containing 1A
RSBN1 round spermatid basic protein 1
SDAD1 SDA1 domain containing 1
SHCBP1 SHC SH2-domain binding protein 1
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SNX6 sorting nexin 6
THAP1 THAP domain containing, apoptosis associated protein 1
TM7SF3 transmembrane 7 superfamily member 3
TMEM135 transmembrane protein 135
TMEM14A transmembrane protein 14A
TMEM183A transmembrane protein 183A
TRHDE thyrotropin-releasing hormone degrading enzyme
TRIM8 tripartite motif containing 8
TRMT12 tRNA methyltransferase 12 homolog (S. cerevisiae)
TSC1 tuberous sclerosis 1
TSEN34 TSEN34 tRNA splicing endonuclease subunit
TSPAN32 tetraspanin 32
TVP23B trans-golgi network vesicle protein 23 homolog B (S. cerevisiae)
UBA2 ubiquitin-like modifier activating enzyme 2
UNKL unkempt family zinc finger-like
USB1 U6 snRNA biogenesis 1
USP6 ubiquitin specific peptidase 6
VASP vasodilator-stimulated phosphoprotein
WDR82 WD repeat domain 82
YIPF3 Yip1 domain family, member 3
ZDHHC13 zinc finger, DHHC-type containing 13
ZNF14 zinc finger protein 14
ZNF282 zinc finger protein 282
ZNF586 zinc finger protein 586