edrophonium chloride-1936 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the edrophonium chloride-1936 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAK1 AP2 associated kinase 1
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCF2 ATP-binding cassette, sub-family F (GCN20), member 2
ANGEL1 angel homolog 1 (Drosophila)
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
APH1B APH1B gamma secretase subunit
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10
ARL4C ADP-ribosylation factor-like 4C
ATXN7L3B ataxin 7-like 3B
B9D1 B9 protein domain 1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
C7ORF26 chromosome 7 open reading frame 26
CACNB3 calcium channel, voltage-dependent, beta 3 subunit
CAPRIN1 cell cycle associated protein 1
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCPG1 cell cycle progression 1
CDC45 cell division cycle 45
CHST3 carbohydrate (chondroitin 6) sulfotransferase 3
CIZ1 CDKN1A interacting zinc finger protein 1
CYB561 cytochrome b561
DCAF8 DDB1 and CUL4 associated factor 8
DDX27 DEAD (Asp-Glu-Ala-Asp) box polypeptide 27
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal
DENND2A DENN/MADD domain containing 2A
DESI1 desumoylating isopeptidase 1
DGKD diacylglycerol kinase, delta 130kDa
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
ELF1 E74-like factor 1 (ets domain transcription factor)
EPB41L1 erythrocyte membrane protein band 4.1-like 1
EPHB2 EPH receptor B2
FCMR Fc fragment of IgM receptor
FGFR1OP FGFR1 oncogene partner
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
GRK6 G protein-coupled receptor kinase 6
GSK3A glycogen synthase kinase 3 alpha
GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa
H2AFY2 H2A histone family, member Y2
HOXB5 homeobox B5
HOXD1 homeobox D1
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
HTRA2 HtrA serine peptidase 2
IDS iduronate 2-sulfatase
IGKV1D-13 immunoglobulin kappa variable 1D-13
IL17RB interleukin 17 receptor B
KRI1 KRI1 homolog (S. cerevisiae)
LIAS lipoic acid synthetase
LIMCH1 LIM and calponin homology domains 1
LMO4 LIM domain only 4
LPIN1 lipin 1
LPP LIM domain containing preferred translocation partner in lipoma
LRRC14 leucine rich repeat containing 14
LY6E lymphocyte antigen 6 complex, locus E
MAP4 microtubule-associated protein 4
MED1 mediator complex subunit 1
MED16 mediator complex subunit 16
MED27 mediator complex subunit 27
MICALL1 MICAL-like 1
MUM1 melanoma associated antigen (mutated) 1
MYCBP MYC binding protein
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
PABPN1 poly(A) binding protein, nuclear 1
PADI2 peptidyl arginine deiminase, type II
PBX2 pre-B-cell leukemia homeobox 2
PDK2 pyruvate dehydrogenase kinase, isozyme 2
PHKG2 phosphorylase kinase, gamma 2 (testis)
PLCG1 phospholipase C, gamma 1
PLSCR3 phospholipid scramblase 3
PMS2P3 postmeiotic segregation increased 2 pseudogene 3
PODXL podocalyxin-like
PPDPF pancreatic progenitor cell differentiation and proliferation factor
PRIM2 primase, DNA, polypeptide 2 (58kDa)
PRKCI protein kinase C, iota
PRKD2 protein kinase D2
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic)
RFXANK regulatory factor X-associated ankyrin-containing protein
RNF167 ring finger protein 167
RPS21 ribosomal protein S21
RSRC1 arginine/serine-rich coiled-coil 1
SIVA1 SIVA1, apoptosis-inducing factor
SLC38A7 solute carrier family 38, member 7
SRBD1 S1 RNA binding domain 1
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
SRF serum response factor (c-fos serum response element-binding transcription factor)
STK10 serine/threonine kinase 10
STX1A syntaxin 1A (brain)
STXBP3 syntaxin binding protein 3
TMEM161A transmembrane protein 161A
USE1 unconventional SNARE in the ER 1 homolog (S. cerevisiae)
USF2 upstream transcription factor 2, c-fos interacting
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae)
WSCD1 WSC domain containing 1
XPC xeroderma pigmentosum, complementation group C
YBX3 Y box binding protein 3
YIPF2 Yip1 domain family, member 2
ZNF211 zinc finger protein 211
ZNF593 zinc finger protein 593
ZNF609 zinc finger protein 609

decreased expression

Symbol Name
AMOTL2 angiomotin like 2
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2
AP1B1 adaptor-related protein complex 1, beta 1 subunit
ARGLU1 arginine and glutamate rich 1
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
BAK1 BCL2-antagonist/killer 1
BBS1 Bardet-Biedl syndrome 1
BTNL3 butyrophilin-like 3
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
CBR4 carbonyl reductase 4
CD53 CD53 molecule
CDC73 cell division cycle 73
CFL1 cofilin 1 (non-muscle)
CHAF1B chromatin assembly factor 1, subunit B (p60)
CISH cytokine inducible SH2-containing protein
CLDND1 claudin domain containing 1
COL4A5 collagen, type IV, alpha 5
COMMD10 COMM domain containing 10
CPA2 carboxypeptidase A2 (pancreatic)
CPOX coproporphyrinogen oxidase
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DCK deoxycytidine kinase
DFNA5 deafness, autosomal dominant 5
DMTN dematin actin binding protein
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DPYD dihydropyrimidine dehydrogenase
E2F8 E2F transcription factor 8
EIF3L eukaryotic translation initiation factor 3, subunit L
ERCC5 excision repair cross-complementation group 5
FAM114A2 family with sequence similarity 114, member A2
FAM169A family with sequence similarity 169, member A
FANCC Fanconi anemia, complementation group C
FBXO46 F-box protein 46
FEM1C fem-1 homolog c (C. elegans)
FURIN furin (paired basic amino acid cleaving enzyme)
GLB1L2 galactosidase, beta 1-like 2
HACD3 3-hydroxyacyl-CoA dehydratase 3
HDAC9 histone deacetylase 9
HIST1H2AJ histone cluster 1, H2aj
KCTD3 potassium channel tetramerization domain containing 3
KIF18A kinesin family member 18A
KIF20B kinesin family member 20B
KLC2 kinesin light chain 2
KNTC1 kinetochore associated 1
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MANBA mannosidase, beta A, lysosomal
MITF microphthalmia-associated transcription factor
MOXD1 monooxygenase, DBH-like 1
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MT1HL1 metallothionein 1H-like 1
NECAP1 NECAP endocytosis associated 1
NFS1 NFS1 cysteine desulfurase
NRSN2 neurensin 2
NT5E 5'-nucleotidase, ecto (CD73)
NUBP2 nucleotide binding protein 2
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
PADI1 peptidyl arginine deiminase, type I
POLDIP2 polymerase (DNA-directed), delta interacting protein 2
POTEKP POTE ankyrin domain family, member K, pseudogene
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
PROSER1 proline and serine rich 1
PTPN9 protein tyrosine phosphatase, non-receptor type 9
RAB17 RAB17, member RAS oncogene family
RPL23AP32 ribosomal protein L23a pseudogene 32
RPRD1A regulation of nuclear pre-mRNA domain containing 1A
RSF1 remodeling and spacing factor 1
SCMH1 sex comb on midleg homolog 1 (Drosophila)
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SERTAD3 SERTA domain containing 3
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SPATS2 spermatogenesis associated, serine-rich 2
STARD13 StAR-related lipid transfer (START) domain containing 13
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TCTA T-cell leukemia translocation altered
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast)
TMEM135 transmembrane protein 135
TMEM184B transmembrane protein 184B
TOP2B topoisomerase (DNA) II beta 180kDa
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRIM45 tripartite motif containing 45
TTF2 transcription termination factor, RNA polymerase II
UBA5 ubiquitin-like modifier activating enzyme 5
UBAC1 UBA domain containing 1
UBE2O ubiquitin-conjugating enzyme E2O
UGGT1 UDP-glucose glycoprotein glucosyltransferase 1
UNC13B unc-13 homolog B (C. elegans)
USP6 ubiquitin specific peptidase 6
YIPF1 Yip1 domain family, member 1
ZFAND3 zinc finger, AN1-type domain 3
ZNF430 zinc finger protein 430
ZNF552 zinc finger protein 552
ZNF562 zinc finger protein 562