earlyonset Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
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Genes

301 genes co-occuring with the biological term earlyonset in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABHD12 abhydrolase domain containing 12
ACE angiotensin I converting enzyme
ACVRL1 activin A receptor type II-like 1
ALMS1 Alstrom syndrome protein 1
ALS2 amyotrophic lateral sclerosis 2 (juvenile)
ANKH ANKH inorganic pyrophosphate transport regulator
APC adenomatous polyposis coli
APOA1 apolipoprotein A-I
APOD apolipoprotein D
APOE apolipoprotein E
APP amyloid beta (A4) precursor protein
APTX aprataxin
AR androgen receptor
ARX aristaless related homeobox
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
ATL1 atlastin GTPase 1
ATP13A2 ATPase type 13A2
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
ATXN2 ataxin 2
ATXN3 ataxin 3
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BARD1 BRCA1 associated RING domain 1
BCHE butyrylcholinesterase
BEST1 bestrophin 1
BLID BH3-like motif containing, cell death inducer
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
BRCA3 breast cancer 3
C2ORF71 chromosome 2 open reading frame 71
C9ORF72 chromosome 9 open reading frame 72
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAV3 caveolin 3
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD36 CD36 molecule (thrombospondin receptor)
CD44 CD44 molecule (Indian blood group)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK4 cyclin-dependent kinase 4
CDK5 cyclin-dependent kinase 5
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39)
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CDKL5 cyclin-dependent kinase-like 5
CDKN2A cyclin-dependent kinase inhibitor 2A
CDNF cerebral dopamine neurotrophic factor
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CECR1 cat eye syndrome chromosome region, candidate 1
CEP250 centrosomal protein 250kDa
CEP290 centrosomal protein 290kDa
CFH complement factor H
CHEK2 checkpoint kinase 2
CHRM3 cholinergic receptor, muscarinic 3
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal)
CLC Charcot-Leyden crystal galectin
COL8A2 collagen, type VIII, alpha 2
COMP cartilage oligomeric matrix protein
COMT catechol-O-methyltransferase
COX15 cytochrome c oxidase assembly homolog 15 (yeast)
COX20 COX20 cytochrome c oxidase assembly factor
CRB1 crumbs family member 1, photoreceptor morphogenesis associated
CTSV cathepsin V
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DEFB1 defensin, beta 1
DIO2 deiodinase, iodothyronine, type II
DISC1 disrupted in schizophrenia 1
DLK1 delta-like 1 homolog (Drosophila)
DMD dystrophin
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DRD3 dopamine receptor D3
EARS2 glutamyl-tRNA synthetase 2, mitochondrial
EDN1 endothelin 1
EGFL7 EGF-like-domain, multiple 7
EIF5A eukaryotic translation initiation factor 5A
ENG endoglin
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERCC2 excision repair cross-complementation group 2
F13A1 coagulation factor XIII, A1 polypeptide
FAM126A family with sequence similarity 126, member A
FBN1 fibrillin 1
FBXO7 F-box protein 7
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FGFR2 fibroblast growth factor receptor 2
FLG filaggrin
FLT1 fms-related tyrosine kinase 1
FOXF2 forkhead box F2
FOXP3 forkhead box P3
FUS FUS RNA binding protein
GAA glucosidase, alpha; acid
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GATA2 GATA binding protein 2
GATA3 GATA binding protein 3
GBA glucosidase, beta, acid
GCH1 GTP cyclohydrolase 1
GCK glucokinase (hexokinase 4)
GDAP1 ganglioside induced differentiation associated protein 1
GIGYF2 GRB10 interacting GYF protein 2
GJA5 gap junction protein, alpha 5, 40kDa
GJB2 gap junction protein, beta 2, 26kDa
GNAS GNAS complex locus
GPR101 G protein-coupled receptor 101
GSTM1 glutathione S-transferase mu 1
GSTO1 glutathione S-transferase omega 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
GSTZ1 glutathione S-transferase zeta 1
H19 H19, imprinted maternally expressed transcript (non-protein coding)
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4
HCRT hypocretin (orexin) neuropeptide precursor
HLA-C major histocompatibility complex, class I, C
HLA-G major histocompatibility complex, class I, G
HNF1A HNF1 homeobox A
HNF4A hepatocyte nuclear factor 4, alpha
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1
HSPA4 heat shock 70kDa protein 4
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
IFNAR1 interferon (alpha, beta and omega) receptor 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IL10 interleukin 10
IL10RA interleukin 10 receptor, alpha
IL10RB interleukin 10 receptor, beta
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL21 interleukin 21
IL2RA interleukin 2 receptor, alpha
IL6 interleukin 6
IL7R interleukin 7 receptor
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1
INS insulin
IQCB1 IQ motif containing B1
IRAK3 interleukin-1 receptor-associated kinase 3
IRGM immunity-related GTPase family, M
IRS1 insulin receptor substrate 1
ITM2B integral membrane protein 2B
JPH3 junctophilin 3
KALRN kalirin, RhoGEF kinase
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KDR kinase insert domain receptor
KL klotho
KRT20 keratin 20, type I
KSR2 kinase suppressor of ras 2
LAMC1 laminin, gamma 1 (formerly LAMB2)
LGALS13 lectin, galactoside-binding, soluble, 13
LIPG lipase, endothelial
LITAF lipopolysaccharide-induced TNF factor
LPIN1 lipin 1
LPIN2 lipin 2
LPIN3 lipin 3
LPL lipoprotein lipase
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
LRRK2 leucine-rich repeat kinase 2
LTA lymphotoxin alpha
LYST lysosomal trafficking regulator
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAPT microtubule-associated protein tau
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MC4R melanocortin 4 receptor
MCDR3 macular dystrophy, retinal 3
MDM4 MDM4, p53 regulator
MFN2 mitofusin 2
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MLH1 mutL homolog 1
MPO myeloperoxidase
MPZ myelin protein zero
MRAP2 melanocortin 2 receptor accessory protein 2
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
MSH2 mutS homolog 2
MSH6 mutS homolog 6
MUTYH mutY homolog
MYH7 myosin, heavy chain 7, cardiac muscle, beta
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
NCSTN nicastrin
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa
NES nestin
NEUROD1 neuronal differentiation 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NMNAT1 nicotinamide nucleotide adenylyltransferase 1
NOD2 nucleotide-binding oligomerization domain containing 2
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH4 notch 4
NOV nephroblastoma overexpressed
NPY neuropeptide Y
NPY2R neuropeptide Y receptor Y2
NQO1 NAD(P)H dehydrogenase, quinone 1
OPA1 optic atrophy 1 (autosomal dominant)
OPRM1 opioid receptor, mu 1
PACRG PARK2 co-regulated
PALB2 partner and localizer of BRCA2
PALLD palladin, cytoskeletal associated protein
PAPPA pregnancy-associated plasma protein A, pappalysin 1
PARK2 parkin RBR E3 ubiquitin protein ligase
PARK7 parkinson protein 7
PARL presenilin associated, rhomboid-like
PAX8 paired box 8
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
PCLO piccolo presynaptic cytomatrix protein
PCSK9 proprotein convertase subtilisin/kexin type 9
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PDX1 pancreatic and duodenal homeobox 1
PEX5 peroxisomal biogenesis factor 5
PGF placental growth factor
PIGA phosphatidylinositol glycan anchor biosynthesis, class A
PINK1 PTEN induced putative kinase 1
PITX2 paired-like homeodomain 2
PITX3 paired-like homeodomain 3
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PMP22 peripheral myelin protein 22
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
POLG polymerase (DNA directed), gamma
POMC proopiomelanocortin
PON1 paraoxonase 1
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PRNP prion protein
PROCR protein C receptor, endothelial
PRX periaxin
PSEN1 presenilin 1
PSEN2 presenilin 2
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4
PSORS9 psoriasis susceptibility 9
PTEN phosphatase and tensin homolog
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PYY peptide YY
RAG1 recombination activating gene 1
RDH12 retinol dehydrogenase 12 (all-trans/9-cis/11-cis)
REEP2 receptor accessory protein 2
REL v-rel avian reticuloendotheliosis viral oncogene homolog
REN renin
RLBP1 retinaldehyde binding protein 1
RP1 retinitis pigmentosa 1 (autosomal dominant)
RUNX3 runt-related transcription factor 3
S100B S100 calcium binding protein B
SBF2 SET binding factor 2
SCN5A sodium channel, voltage gated, type V alpha subunit
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SH3GL2 SH3-domain GRB2-like 2
SLC13A5 solute carrier family 13 (sodium-dependent citrate transporter), member 5
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC26A4 solute carrier family 26 (anion exchanger), member 4
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC35A2 solute carrier family 35 (UDP-galactose transporter), member A2
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SMAD3 SMAD family member 3
SNAP25 synaptosomal-associated protein, 25kDa
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOD1 superoxide dismutase 1, soluble
SOD2 superoxide dismutase 2, mitochondrial
SPINK1 serine peptidase inhibitor, Kazal type 1
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SREBF2 sterol regulatory element binding transcription factor 2
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STAT4 signal transducer and activator of transcription 4
SYNJ1 synaptojanin 1
TARDBP TAR DNA binding protein
TBX19 T-box 19
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFF1 trefoil factor 1
TFR2 transferrin receptor 2
TGFB1 transforming growth factor, beta 1
TGFBI transforming growth factor, beta-induced, 68kDa
TH tyrosine hydroxylase
THAP1 THAP domain containing, apoptosis associated protein 1
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TNFRSF4 tumor necrosis factor receptor superfamily, member 4
TOR1A torsin family 1, member A (torsin A)
TP53 tumor protein p53
TREM2 triggering receptor expressed on myeloid cells 2
TREX1 three prime repair exonuclease 1
TRG T cell receptor gamma locus
TRIB3 tribbles pseudokinase 3
TRPC6 transient receptor potential cation channel, subfamily C, member 6
TSFM Ts translation elongation factor, mitochondrial
TTN titin
TTR transthyretin
TULP1 tubby like protein 1
UBL5 ubiquitin-like 5
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UFD1L ubiquitin fusion degradation 1 like (yeast)
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1
VAMP8 vesicle-associated membrane protein 8
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VKORC1 vitamin K epoxide reductase complex, subunit 1
WT1 Wilms tumor 1