drug dependence Gene Set

Dataset GWASdb SNP-Disease Associations
Category disease or phenotype associations
Type disease
Description A substance dependence that involves the continued use of drugs despite problems related to use of the substance. (Human Disease Ontology, DOID_9974)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/DOID:9974
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Genes

71 genes associated with the disease drug dependence in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.

Symbol Name Standardized Value
NCK2 NCK adaptor protein 2 1.63837
NFASC neurofascin 1.62029
KCNG2 potassium channel, voltage gated modifier subfamily G, member 2 1.53704
PARVA parvin, alpha 1.4001
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 1.39592
KCNC1 potassium channel, voltage gated Shaw related subfamily C, member 1 1.24194
CREB1 cAMP responsive element binding protein 1 0.945129
ELAVL2 ELAV like neuron-specific RNA binding protein 2 0.889594
C3ORF20 chromosome 3 open reading frame 20 0.821519
SLC8A2 solute carrier family 8 (sodium/calcium exchanger), member 2 0.805638
SAMD3 sterile alpha motif domain containing 3 0.803948
SPON1 spondin 1, extracellular matrix protein 0.720532
CTNND2 catenin (cadherin-associated protein), delta 2 0.628889
LGSN lengsin, lens protein with glutamine synthetase domain 0.600463
CSMD1 CUB and Sushi multiple domains 1 0.59964
CHN2 chimerin 2 0.535269
LINC00547 long intergenic non-protein coding RNA 547 0.526189
RIMS2 regulating synaptic membrane exocytosis 2 0.498333
NCAM1 neural cell adhesion molecule 1 0.471314
FAM53B family with sequence similarity 53, member B 0.468362
NCOR2 nuclear receptor corepressor 2 0.446685
ANKRD31 ankyrin repeat domain 31 0.431406
CPE carboxypeptidase E 0.425834
CDK1 cyclin-dependent kinase 1 0.425585
FERMT1 fermitin family member 1 0.425023
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2 0.424412
ZSWIM5 zinc finger, SWIM-type containing 5 0.423937
GCOM1 GRINL1A complex locus 1 0.423654
RNF43 ring finger protein 43 0.421993
C1QL2 complement component 1, q subcomponent-like 2 0.419094
CSMD3 CUB and Sushi multiple domains 3 0.413127
SCGB1D4 secretoglobin, family 1D, member 4 0.40944
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.409312
LGR6 leucine-rich repeat containing G protein-coupled receptor 6 0.403622
STEAP3 STEAP family member 3, metalloreductase 0.400981
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.39324
AOAH acyloxyacyl hydrolase (neutrophil) 0.393061
FHOD3 formin homology 2 domain containing 3 0.392249
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.390074
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.387281
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.38467
CHST3 carbohydrate (chondroitin 6) sulfotransferase 3 0.383522
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 0.382423
FAM134B family with sequence similarity 134, member B 0.381863
GP6 glycoprotein VI (platelet) 0.373952
ADGRE1 adhesion G protein-coupled receptor E1 0.37351
BPIFB4 BPI fold containing family B, member 4 0.373272
FAM107B family with sequence similarity 107, member B 0.373143
LINC01121 long intergenic non-protein coding RNA 1121 0.372658
DEPTOR DEP domain containing MTOR-interacting protein 0.365911
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 0.365459
HDAC5 histone deacetylase 5 0.362958
HSF5 heat shock transcription factor family member 5 0.36207
VTI1A vesicle transport through interaction with t-SNAREs 1A 0.358174
RSU1 Ras suppressor protein 1 0.356467
VWF von Willebrand factor 0.356061
PIGB phosphatidylinositol glycan anchor biosynthesis, class B 0.354144
EHD4 EH-domain containing 4 0.352225
MTMR4 myotubularin related protein 4 0.34929
GRM8 glutamate receptor, metabotropic 8 0.348723
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 0.348723
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 0.348723
SYT2 synaptotagmin II 0.34673
MBL2 mannose-binding lectin (protein C) 2, soluble 0.332692
GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3 0.330425
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 0.330425
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2 0.330425
POLR1A polymerase (RNA) I polypeptide A, 194kDa 0.329422
GRIK4 glutamate receptor, ionotropic, kainate 4 0.329388
KRT73 keratin 73, type II 0.329087
ADRA1A adrenoceptor alpha 1A 0.327111