doxepin-2384 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the doxepin-2384 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADD2 adducin 2 (beta)
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
APOE apolipoprotein E
ARRB2 arrestin, beta 2
B3GALNT1 beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
C19ORF66 chromosome 19 open reading frame 66
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CD24 CD24 molecule
CD59 CD59 molecule, complement regulatory protein
CDHR2 cadherin-related family member 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CLEC3B C-type lectin domain family 3, member B
COPZ2 coatomer protein complex, subunit zeta 2
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CYHR1 cysteine/histidine-rich 1
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
DGCR2 DiGeorge syndrome critical region gene 2
DGCR8 DGCR8 microprocessor complex subunit
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34
DOLK dolichol kinase
EGR1 early growth response 1
EIF5A2 eukaryotic translation initiation factor 5A2
ENDOD1 endonuclease domain containing 1
FAM127B family with sequence similarity 127, member B
FAM3A family with sequence similarity 3, member A
FAM63B family with sequence similarity 63, member B
FBXO40 F-box protein 40
FOXG1 forkhead box G1
FUT2 fucosyltransferase 2 (secretor status included)
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4
GBP2 guanylate binding protein 2, interferon-inducible
GLIPR1 GLI pathogenesis-related 1
GP6 glycoprotein VI (platelet)
GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
HEXIM1 hexamethylene bis-acetamide inducible 1
HFE hemochromatosis
HHLA3 HERV-H LTR-associating 3
HOMER3 homer scaffolding protein 3
HOXA1 homeobox A1
HOXA4 homeobox A4
HOXD9 homeobox D9
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
ICA1 islet cell autoantigen 1, 69kDa
ICOSLG inducible T-cell co-stimulator ligand
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
INHBA inhibin, beta A
INPP5K inositol polyphosphate-5-phosphatase K
KDM4B lysine (K)-specific demethylase 4B
KLF3 Kruppel-like factor 3 (basic)
KLHL36 kelch-like family member 36
L3MBTL1 l(3)mbt-like 1 (Drosophila)
MAP3K12 mitogen-activated protein kinase kinase kinase 12
MAPK8 mitogen-activated protein kinase 8
MAPT microtubule-associated protein tau
MATN1 matrilin 1, cartilage matrix protein
MCOLN1 mucolipin 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MST1 macrophage stimulating 1
NCLN nicalin
NUDT13 nudix (nucleoside diphosphate linked moiety X)-type motif 13
PAIP2B poly(A) binding protein interacting protein 2B
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PDE4D phosphodiesterase 4D, cAMP-specific
PDLIM2 PDZ and LIM domain 2 (mystique)
PHC1 polyhomeotic homolog 1 (Drosophila)
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLP1 proteolipid protein 1
PRDM1 PR domain containing 1, with ZNF domain
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PYGB phosphorylase, glycogen; brain
QSER1 glutamine and serine rich 1
RASAL2 RAS protein activator like 2
RBKS ribokinase
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae)
RPL13P5 ribosomal protein L13 pseudogene 5
RUNX1 runt-related transcription factor 1
RXRB retinoid X receptor, beta
SAMD4A sterile alpha motif domain containing 4A
SIGLEC7 sialic acid binding Ig-like lectin 7
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLMO1 slowmo homolog 1 (Drosophila)
SOS2 son of sevenless homolog 2 (Drosophila)
SRR serine racemase
SSBP2 single-stranded DNA binding protein 2
STS steroid sulfatase (microsomal), isozyme S
STX1A syntaxin 1A (brain)
STX5 syntaxin 5
THRB thyroid hormone receptor, beta
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TSC22D4 TSC22 domain family, member 4
ZNF185 zinc finger protein 185 (LIM domain)
ZNF287 zinc finger protein 287
ZNF34 zinc finger protein 34
ZNF500 zinc finger protein 500
ZNF510 zinc finger protein 510
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2
ADTRP androgen-dependent TFPI-regulating protein
ALDOC aldolase C, fructose-bisphosphate
ALPK1 alpha-kinase 1
ALS2CL ALS2 C-terminal like
ANKRD36 ankyrin repeat domain 36
APOBR apolipoprotein B receptor
APOL6 apolipoprotein L, 6
ARHGAP10 Rho GTPase activating protein 10
ARHGAP12 Rho GTPase activating protein 12
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ASPN asporin
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BAHD1 bromo adjacent homology domain containing 1
BHLHE41 basic helix-loop-helix family, member e41
C14ORF93 chromosome 14 open reading frame 93
C17ORF80 chromosome 17 open reading frame 80
C1ORF95 chromosome 1 open reading frame 95
C9ORF9 chromosome 9 open reading frame 9
CAPN5 calpain 5
CCDC176 coiled-coil domain containing 176
CCDC85C coiled-coil domain containing 85C
CCNT1 cyclin T1
CD70 CD70 molecule
CDA cytidine deaminase
CIC capicua transcriptional repressor
CIDEC cell death-inducing DFFA-like effector c
CLCF1 cardiotrophin-like cytokine factor 1
CNPY4 canopy FGF signaling regulator 4
COLEC10 collectin sub-family member 10 (C-type lectin)
CRYL1 crystallin, lambda 1
DDN dendrin
DENND2D DENN/MADD domain containing 2D
DGAT1 diacylglycerol O-acyltransferase 1
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EML4 echinoderm microtubule associated protein like 4
ERCC4 excision repair cross-complementation group 4
FAM102A family with sequence similarity 102, member A
FAM204A family with sequence similarity 204, member A
GALT galactose-1-phosphate uridylyltransferase
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1
GPR27 G protein-coupled receptor 27
HIST1H2AJ histone cluster 1, H2aj
IFT46 intraflagellar transport 46
INF2 inverted formin, FH2 and WH2 domain containing
KLF1 Kruppel-like factor 1 (erythroid)
KLHL26 kelch-like family member 26
L2HGDH L-2-hydroxyglutarate dehydrogenase
LAIR2 leukocyte-associated immunoglobulin-like receptor 2
LIN7B lin-7 homolog B (C. elegans)
LINC00597 long intergenic non-protein coding RNA 597
LRP2 low density lipoprotein receptor-related protein 2
LTBP2 latent transforming growth factor beta binding protein 2
MCMBP minichromosome maintenance complex binding protein
MED15 mediator complex subunit 15
MEGF8 multiple EGF-like-domains 8
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MTG1 mitochondrial ribosome-associated GTPase 1
MXD3 MAX dimerization protein 3
NAT6 N-acetyltransferase 6 (GCN5-related)
NCS1 neuronal calcium sensor 1
NPFFR1 neuropeptide FF receptor 1
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PDZD7 PDZ domain containing 7
PHKG2 phosphorylase kinase, gamma 2 (testis)
PIGL phosphatidylinositol glycan anchor biosynthesis, class L
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
PODXL2 podocalyxin-like 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKG2 protein kinase, cGMP-dependent, type II
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RABL6 RAB, member RAS oncogene family-like 6
RGP1 RGP1 retrograde golgi transport homolog (S. cerevisiae)
RNF31 ring finger protein 31
S1PR4 sphingosine-1-phosphate receptor 4
SHARPIN SHANK-associated RH domain interactor
SLC22A14 solute carrier family 22, member 14
SLC44A1 solute carrier family 44 (choline transporter), member 1
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SPATS2 spermatogenesis associated, serine-rich 2
STEAP3 STEAP family member 3, metalloreductase
STXBP1 syntaxin binding protein 1
TET3 tet methylcytosine dioxygenase 3
TM7SF2 transmembrane 7 superfamily member 2
TMC7 transmembrane channel-like 7
TMEM187 transmembrane protein 187
TMEM209 transmembrane protein 209
TMOD3 tropomodulin 3 (ubiquitous)
TMUB2 transmembrane and ubiquitin-like domain containing 2
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TSPAN5 tetraspanin 5
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
WARS2 tryptophanyl tRNA synthetase 2, mitochondrial
ZC2HC1A zinc finger, C2HC-type containing 1A
ZNF350 zinc finger protein 350
ZNF354A zinc finger protein 354A
ZNF552 zinc finger protein 552