domperidone-2655 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the domperidone-2655 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
ACRV1 acrosomal vesicle protein 1
APLP1 amyloid beta (A4) precursor-like protein 1
ARHGAP33 Rho GTPase activating protein 33
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10
ARID5A AT rich interactive domain 5A (MRF1-like)
ASPHD1 aspartate beta-hydroxylase domain containing 1
C1ORF159 chromosome 1 open reading frame 159
CACNB2 calcium channel, voltage-dependent, beta 2 subunit
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase)
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
COL4A1 collagen, type IV, alpha 1
CSF1 colony stimulating factor 1 (macrophage)
CST4 cystatin S
CXORF21 chromosome X open reading frame 21
DOK2 docking protein 2, 56kDa
EHD2 EH-domain containing 2
ELF4 E74-like factor 4 (ets domain transcription factor)
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ENO3 enolase 3 (beta, muscle)
ETV4 ets variant 4
FGFR2 fibroblast growth factor receptor 2
FHOD1 formin homology 2 domain containing 1
FOSL2 FOS-like antigen 2
FOXF1 forkhead box F1
FSTL3 follistatin-like 3 (secreted glycoprotein)
FXR2 fragile X mental retardation, autosomal homolog 2
GAS1 growth arrest-specific 1
GPR153 G protein-coupled receptor 153
HCFC1 host cell factor C1
HDAC7 histone deacetylase 7
HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2
HSPG2 heparan sulfate proteoglycan 2
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
ICOSLG inducible T-cell co-stimulator ligand
IGHMBP2 immunoglobulin mu binding protein 2
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2
KCNK10 potassium channel, two pore domain subfamily K, member 10
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2
KHSRP KH-type splicing regulatory protein
KIAA1024 KIAA1024
KIAA1456 KIAA1456
KIF1C kinesin family member 1C
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAP3K9 mitogen-activated protein kinase kinase kinase 9
MARK4 MAP/microtubule affinity-regulating kinase 4
MCF2 MCF.2 cell line derived transforming sequence
MIER2 mesoderm induction early response 1, family member 2
MMP17 matrix metallopeptidase 17 (membrane-inserted)
MUC3B mucin 3B, cell surface associated
MUM1 melanoma associated antigen (mutated) 1
MYO9B myosin IXB
NCR2 natural cytotoxicity triggering receptor 2
NPR1 natriuretic peptide receptor 1
NPTX1 neuronal pentraxin I
OPRL1 opiate receptor-like 1
PCDHB8 protocadherin beta 8
PDE3B phosphodiesterase 3B, cGMP-inhibited
PELP1 proline, glutamate and leucine rich protein 1
PLK3 polo-like kinase 3
POU4F1 POU class 4 homeobox 1
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
PRDX2 peroxiredoxin 2
PRO2964 uncharacterized protein PRO2964
PTPRU protein tyrosine phosphatase, receptor type, U
RAP2B RAP2B, member of RAS oncogene family
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RHBDD3 rhomboid domain containing 3
RPL35A ribosomal protein L35a
RPS4Y1 ribosomal protein S4, Y-linked 1
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SFTPD surfactant protein D
SH3BP2 SH3-domain binding protein 2
SHANK2 SH3 and multiple ankyrin repeat domains 2
SLC1A7 solute carrier family 1 (glutamate transporter), member 7
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SNAPC5 small nuclear RNA activating complex, polypeptide 5, 19kDa
SPEF1 sperm flagellar 1
SPON2 spondin 2, extracellular matrix protein
SPTAN1 spectrin, alpha, non-erythrocytic 1
STRN4 striatin, calmodulin binding protein 4
SYN1 synapsin I
TACR1 tachykinin receptor 1
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TP63 tumor protein p63
TRIM46 tripartite motif containing 46
TRPM6 transient receptor potential cation channel, subfamily M, member 6
UBOX5 U-box domain containing 5
UBXN1 UBX domain protein 1
USP2 ubiquitin specific peptidase 2
WIPF1 WAS/WASL interacting protein family, member 1
YTHDC1 YTH domain containing 1
ZNF747 zinc finger protein 747

decreased expression

Symbol Name
ADAM15 ADAM metallopeptidase domain 15
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
AIDA axin interactor, dorsalization associated
AP1AR adaptor-related protein complex 1 associated regulatory protein
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
ARHGAP11A Rho GTPase activating protein 11A
ARID4A AT rich interactive domain 4A (RBP1-like)
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa
ARRB1 arrestin, beta 1
BCORL1 BCL6 corepressor-like 1
BIK BCL2-interacting killer (apoptosis-inducing)
BRIP1 BRCA1 interacting protein C-terminal helicase 1
BSG basigin (Ok blood group)
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated
CAPRIN1 cell cycle associated protein 1
CDC37 cell division cycle 37
CDC37L1 cell division cycle 37-like 1
CDK3 cyclin-dependent kinase 3
CDK9 cyclin-dependent kinase 9
CDKN2AIP CDKN2A interacting protein
CHKB choline kinase beta
CLDND1 claudin domain containing 1
CRIP2 cysteine-rich protein 2
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
DDA1 DET1 and DDB1 associated 1
DNA2 DNA replication helicase/nuclease 2
EDC3 enhancer of mRNA decapping 3
EFNA3 ephrin-A3
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
FZD3 frizzled class receptor 3
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GALK1 galactokinase 1
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C
GDE1 glycerophosphodiester phosphodiesterase 1
GLI3 GLI family zinc finger 3
GMEB1 glucocorticoid modulatory element binding protein 1
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GOLGA8B golgin A8 family, member B
GSR glutathione reductase
GTF2I general transcription factor IIi
GUSBP3 glucuronidase, beta pseudogene 3
H2BFS H2B histone family, member S (pseudogene)
HP1BP3 heterochromatin protein 1, binding protein 3
IGFBP6 insulin-like growth factor binding protein 6
IREB2 iron-responsive element binding protein 2
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
KLF3 Kruppel-like factor 3 (basic)
KPNA4 karyopherin alpha 4 (importin alpha 3)
KRT13 keratin 13, type I
LACTB2 lactamase, beta 2
LOC100287590 uncharacterized LOC100287590
LOC257152 uncharacterized LOC257152
LYRM2 LYR motif containing 2
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MBTPS2 membrane-bound transcription factor peptidase, site 2
MECR mitochondrial trans-2-enoyl-CoA reductase
METTL16 methyltransferase like 16
MOCS3 molybdenum cofactor synthesis 3
MPDU1 mannose-P-dolichol utilization defect 1
MXD3 MAX dimerization protein 3
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit
NEIL3 nei endonuclease VIII-like 3 (E. coli)
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
PADI1 peptidyl arginine deiminase, type I
PARPBP PARP1 binding protein
PCYOX1 prenylcysteine oxidase 1
PERP PERP, TP53 apoptosis effector
PEX26 peroxisomal biogenesis factor 26
PGD phosphogluconate dehydrogenase
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PPAP2C phosphatidic acid phosphatase type 2C
PSENEN presenilin enhancer gamma secretase subunit
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
RAB23 RAB23, member RAS oncogene family
RCOR3 REST corepressor 3
RGS17 regulator of G-protein signaling 17
RNFT1 ring finger protein, transmembrane 1
SCYL2 SCY1-like 2 (S. cerevisiae)
SELT selenoprotein T
SETD8 SET domain containing (lysine methyltransferase) 8
SGPP1 sphingosine-1-phosphate phosphatase 1
SPIN1 spindlin 1
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
SYTL2 synaptotagmin-like 2
TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa
TAGLN transgelin
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TMEM230 transmembrane protein 230
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast)
TRAPPC6A trafficking protein particle complex 6A
TSPAN1 tetraspanin 1
YIPF5 Yip1 domain family, member 5
ZFYVE21 zinc finger, FYVE domain containing 21
ZNF253 zinc finger protein 253
ZNF654 zinc finger protein 654
ZNF816 zinc finger protein 816
ZWILCH zwilch kinetochore protein