dobutamine-6286 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the dobutamine-6286 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
APC adenomatous polyposis coli
AQP3 aquaporin 3 (Gill blood group)
ARHGAP44 Rho GTPase activating protein 44
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARR3 arrestin 3, retinal (X-arrestin)
ATF3 activating transcription factor 3
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BCL2L11 BCL2-like 11 (apoptosis facilitator)
C1ORF61 chromosome 1 open reading frame 61
CALCR calcitonin receptor
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CELA2A chymotrypsin-like elastase family, member 2A
CEMIP cell migration inducing protein, hyaluronan binding
CGA glycoprotein hormones, alpha polypeptide
CLN8 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
CNOT4 CCR4-NOT transcription complex, subunit 4
CNTD2 cyclin N-terminal domain containing 2
COL11A2 collagen, type XI, alpha 2
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTH cystathionine gamma-lyase
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
CXCL8 chemokine (C-X-C motif) ligand 8
DFNB31 deafness, autosomal recessive 31
DHRS9 dehydrogenase/reductase (SDR family) member 9
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EPAS1 endothelial PAS domain protein 1
ETNK2 ethanolamine kinase 2
FGFR1 fibroblast growth factor receptor 1
GAL galanin/GMAP prepropeptide
GPRC5A G protein-coupled receptor, class C, group 5, member A
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HAAO 3-hydroxyanthranilate 3,4-dioxygenase
HBEGF heparin-binding EGF-like growth factor
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IL11 interleukin 11
IL1R2 interleukin 1 receptor, type II
IL1RL1 interleukin 1 receptor-like 1
ISG20 interferon stimulated exonuclease gene 20kDa
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIAA1107 KIAA1107
KLHDC3 kelch domain containing 3
KRT6B keratin 6B, type II
KRT8P12 keratin 8 pseudogene 12
LIG3 ligase III, DNA, ATP-dependent
LMNA lamin A/C
MAP7 microtubule-associated protein 7
MMRN2 multimerin 2
MYH14 myosin, heavy chain 14, non-muscle
N4BP1 NEDD4 binding protein 1
NDRG4 NDRG family member 4
NF1 neurofibromin 1
NPEPL1 aminopeptidase-like 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NT5M 5',3'-nucleotidase, mitochondrial
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OVOL2 ovo-like zinc finger 2
PAPPA2 pappalysin 2
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1
PLIN2 perilipin 2
PRB1 proline-rich protein BstNI subfamily 1
PRDM14 PR domain containing 14
PTCH1 patched 1
PTGES prostaglandin E synthase
PTHLH parathyroid hormone-like hormone
PTK6 protein tyrosine kinase 6
PXMP4 peroxisomal membrane protein 4, 24kDa
RAB11FIP3 RAB11 family interacting protein 3 (class II)
RBM12B RNA binding motif protein 12B
RPH3AL rabphilin 3A-like (without C2 domains)
RRAGB Ras-related GTP binding B
S100P S100 calcium binding protein P
SCAMP1 secretory carrier membrane protein 1
SCAPER S-phase cyclin A-associated protein in the ER
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SIRT5 sirtuin 5
SMOX spermine oxidase
SND1-IT1 SND1 intronic transcript 1
SOGA1 suppressor of glucose, autophagy associated 1
SRRT serrate, RNA effector molecule
STC1 stanniocalcin 1
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
TBC1D30 TBC1 domain family, member 30
TBL1X transducin (beta)-like 1X-linked
TEX15 testis expressed 15
TGFB2 transforming growth factor, beta 2
TMEM53 transmembrane protein 53
TNC tenascin C
TRANK1 tetratricopeptide repeat and ankyrin repeat containing 1
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
ZNF768 zinc finger protein 768

decreased expression

Symbol Name
ACTR3B ARP3 actin-related protein 3 homolog B (yeast)
ADAM15 ADAM metallopeptidase domain 15
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ANOS1 anosmin 1
APLP1 amyloid beta (A4) precursor-like protein 1
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASB7 ankyrin repeat and SOCS box containing 7
BIRC3 baculoviral IAP repeat containing 3
C17ORF70 chromosome 17 open reading frame 70
C3ORF52 chromosome 3 open reading frame 52
CCDC25 coiled-coil domain containing 25
CCDC85C coiled-coil domain containing 85C
CCS copper chaperone for superoxide dismutase
CD70 CD70 molecule
CDADC1 cytidine and dCMP deaminase domain containing 1
CLCN2 chloride channel, voltage-sensitive 2
CTGF connective tissue growth factor
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
ELOVL4 ELOVL fatty acid elongase 4
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3
ESM1 endothelial cell-specific molecule 1
FAM69A family with sequence similarity 69, member A
FKBP1B FK506 binding protein 1B, 12.6 kDa
FSD1 fibronectin type III and SPRY domain containing 1
GAREM GRB2 associated, regulator of MAPK1
GBX2 gastrulation brain homeobox 2
GLCE glucuronic acid epimerase
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPR3 G protein-coupled receptor 3
GRAMD3 GRAM domain containing 3
GRWD1 glutamate-rich WD repeat containing 1
GSTZ1 glutathione S-transferase zeta 1
HDAC5 histone deacetylase 5
HIRA histone cell cycle regulator
HIST1H3G histone cluster 1, H3g
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HOXC8 homeobox C8
HS1BP3 HCLS1 binding protein 3
IFNAR1 interferon (alpha, beta and omega) receptor 1
IL4R interleukin 4 receptor
KIAA1462 KIAA1462
KIF16B kinesin family member 16B
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MEIS1 Meis homeobox 1
MUC3B mucin 3B, cell surface associated
NPM3 nucleophosmin/nucleoplasmin 3
NUDT13 nudix (nucleoside diphosphate linked moiety X)-type motif 13
PALMD palmdelphin
PDE12 phosphodiesterase 12
PDLIM2 PDZ and LIM domain 2 (mystique)
PEX13 peroxisomal biogenesis factor 13
PLAT plasminogen activator, tissue
POMT1 protein-O-mannosyltransferase 1
POR P450 (cytochrome) oxidoreductase
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PRPH peripherin
PRR7 proline rich 7 (synaptic)
PTX3 pentraxin 3, long
QTRT1 queuine tRNA-ribosyltransferase 1
RAB8B RAB8B, member RAS oncogene family
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RHOBTB1 Rho-related BTB domain containing 1
RNF31 ring finger protein 31
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)
RUNDC3B RUN domain containing 3B
SCG5 secretogranin V
SCN1B sodium channel, voltage gated, type I beta subunit
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SH3TC2 SH3 domain and tetratricopeptide repeats 2
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC39A1 solute carrier family 39 (zinc transporter), member 1
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SMAD7 SMAD family member 7
SPATA7 spermatogenesis associated 7
STBD1 starch binding domain 1
STX1A syntaxin 1A (brain)
TEX40 testis expressed 40
THBS3 thrombospondin 3
TMEM242 transmembrane protein 242
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TRIM9 tripartite motif containing 9
TRNAU1AP tRNA selenocysteine 1 associated protein 1
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein
TTC23 tetratricopeptide repeat domain 23
TUBG2 tubulin, gamma 2
ZBTB39 zinc finger and BTB domain containing 39
ZDHHC24 zinc finger, DHHC-type containing 24
ZNF197 zinc finger protein 197
ZNF214 zinc finger protein 214
ZNF253 zinc finger protein 253
ZNF324 zinc finger protein 324
ZNF747 zinc finger protein 747
ZNF767P zinc finger family member 767, pseudogene