dizocilpine-6223 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the dizocilpine-6223 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ARC activity-regulated cytoskeleton-associated protein
ARID1A AT rich interactive domain 1A (SWI-like)
BMP6 bone morphogenetic protein 6
C14ORF105 chromosome 14 open reading frame 105
C2CD2L C2CD2-like
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
CRYBB2P1 crystallin, beta B2 pseudogene 1
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant
CXORF21 chromosome X open reading frame 21
CYHR1 cysteine/histidine-rich 1
DAZAP2 DAZ associated protein 2
DGKD diacylglycerol kinase, delta 130kDa
DLX4 distal-less homeobox 4
DNPEP aspartyl aminopeptidase
ECE1 endothelin converting enzyme 1
EGFR epidermal growth factor receptor
EML2 echinoderm microtubule associated protein like 2
EML3 echinoderm microtubule associated protein like 3
FBXL18 F-box and leucine-rich repeat protein 18
FBXO2 F-box protein 2
FKBP8 FK506 binding protein 8, 38kDa
FLJ11292
FXYD2 FXYD domain containing ion transport regulator 2
GPR161 G protein-coupled receptor 161
HCFC1 host cell factor C1
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor
HIST1H2AJ histone cluster 1, H2aj
HLA-C major histocompatibility complex, class I, C
HMOX1 heme oxygenase 1
HOXA6 homeobox A6
ING4 inhibitor of growth family, member 4
INSR insulin receptor
IQSEC2 IQ motif and Sec7 domain 2
IRF6 interferon regulatory factor 6
KAT6A K(lysine) acetyltransferase 6A
KDM8 lysine (K)-specific demethylase 8
KHSRP KH-type splicing regulatory protein
LPCAT3 lysophosphatidylcholine acyltransferase 3
LRRC61 leucine rich repeat containing 61
LUZP1 leucine zipper protein 1
MAP1A microtubule-associated protein 1A
MAP2K5 mitogen-activated protein kinase kinase 5
MAP3K12 mitogen-activated protein kinase kinase kinase 12
MAP4 microtubule-associated protein 4
MFAP3L microfibrillar-associated protein 3-like
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
N4BP1 NEDD4 binding protein 1
NEK11 NIMA-related kinase 11
NEK9 NIMA-related kinase 9
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NGLY1 N-glycanase 1
NOP16 NOP16 nucleolar protein
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
OTUD3 OTU deubiquitinase 3
OVOL2 ovo-like zinc finger 2
PALM paralemmin
PAOX polyamine oxidase (exo-N4-amino)
PCDHB3 protocadherin beta 3
PLCH1 phospholipase C, eta 1
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
POMT2 protein-O-mannosyltransferase 2
PPIA peptidylprolyl isomerase A (cyclophilin A)
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
PTPN21 protein tyrosine phosphatase, non-receptor type 21
PTRF polymerase I and transcript release factor
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RANGAP1 Ran GTPase activating protein 1
RFTN1 raftlin, lipid raft linker 1
RFXAP regulatory factor X-associated protein
RPGR retinitis pigmentosa GTPase regulator
RPL7 ribosomal protein L7
RREB1 ras responsive element binding protein 1
S100A2 S100 calcium binding protein A2
SIVA1 SIVA1, apoptosis-inducing factor
SLC22A14 solute carrier family 22, member 14
SMTN smoothelin
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3
SPTBN1 spectrin, beta, non-erythrocytic 1
SRPX sushi-repeat containing protein, X-linked
SRRM2 serine/arginine repetitive matrix 2
SUGP1 SURP and G patch domain containing 1
TEP1 telomerase-associated protein 1
TIGD6 tigger transposable element derived 6
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast)
TLE2 transducin-like enhancer of split 2
TLN2 talin 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRPM4 transient receptor potential cation channel, subfamily M, member 4
UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast)
USF2 upstream transcription factor 2, c-fos interacting
USP2 ubiquitin specific peptidase 2
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
WNT2B wingless-type MMTV integration site family, member 2B
ZNF282 zinc finger protein 282
ZNF592 zinc finger protein 592

decreased expression

Symbol Name
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BAG2 BCL2-associated athanogene 2
BRIP1 BRCA1 interacting protein C-terminal helicase 1
C3ORF52 chromosome 3 open reading frame 52
C9ORF40 chromosome 9 open reading frame 40
CAPG capping protein (actin filament), gelsolin-like
CAPRIN1 cell cycle associated protein 1
CDC73 cell division cycle 73
CHMP6 charged multivesicular body protein 6
CLDND1 claudin domain containing 1
CLK1 CDC-like kinase 1
COMMD10 COMM domain containing 10
CTAGE9 CTAGE family, member 9
CTSV cathepsin V
DDIT3 DNA-damage-inducible transcript 3
DHRS7B dehydrogenase/reductase (SDR family) member 7B
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF5A2 eukaryotic translation initiation factor 5A2
ELP3 elongator acetyltransferase complex subunit 3
FAM172A family with sequence similarity 172, member A
GDE1 glycerophosphodiester phosphodiesterase 1
GLI3 GLI family zinc finger 3
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GTF2I general transcription factor IIi
HP1BP3 heterochromatin protein 1, binding protein 3
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1
IER3IP1 immediate early response 3 interacting protein 1
IL10RB interleukin 10 receptor, beta
INO80D INO80 complex subunit D
INSIG2 insulin induced gene 2
ISOC1 isochorismatase domain containing 1
JADE3 jade family PHD finger 3
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KCTD20 potassium channel tetramerization domain containing 20
KIF18A kinesin family member 18A
KLHL12 kelch-like family member 12
KRBOX4 KRAB box domain containing 4
LAMA3 laminin, alpha 3
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LRRC16A leucine rich repeat containing 16A
LRRC37A2 leucine rich repeat containing 37, member A2
MAPK12 mitogen-activated protein kinase 12
MBTPS2 membrane-bound transcription factor peptidase, site 2
MDK midkine (neurite growth-promoting factor 2)
MXD3 MAX dimerization protein 3
NMD3 NMD3 ribosome export adaptor
NMRK1 nicotinamide riboside kinase 1
NR1D2 nuclear receptor subfamily 1, group D, member 2
NR1H3 nuclear receptor subfamily 1, group H, member 3
NT5C 5', 3'-nucleotidase, cytosolic
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6
ODF2 outer dense fiber of sperm tails 2
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
PERP PERP, TP53 apoptosis effector
PIKFYVE phosphoinositide kinase, FYVE finger containing
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
PSENEN presenilin enhancer gamma secretase subunit
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
RAB23 RAB23, member RAS oncogene family
RBL1 retinoblastoma-like 1
RFX7 regulatory factor X, 7
RLN2 relaxin 2
RNF146 ring finger protein 146
RPE ribulose-5-phosphate-3-epimerase
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2
SCYL2 SCY1-like 2 (S. cerevisiae)
SECISBP2 SECIS binding protein 2
SELT selenoprotein T
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2
SGPP1 sphingosine-1-phosphate phosphatase 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SNIP1 Smad nuclear interacting protein 1
SPIN1 spindlin 1
STARD13 StAR-related lipid transfer (START) domain containing 13
SYTL2 synaptotagmin-like 2
TDRD1 tudor domain containing 1
TGDS TDP-glucose 4,6-dehydratase
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast)
TMEM260 transmembrane protein 260
TMEM62 transmembrane protein 62
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast)
TRAPPC2 trafficking protein particle complex 2
TRIM25 tripartite motif containing 25
TSPAN1 tetraspanin 1
VCPKMT valosin containing protein lysine (K) methyltransferase
WDR7 WD repeat domain 7
YIPF5 Yip1 domain family, member 5
ZFAND1 zinc finger, AN1-type domain 1
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF254 zinc finger protein 254
ZNF408 zinc finger protein 408
ZNF675 zinc finger protein 675
ZNF84 zinc finger protein 84