distal Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description Distal is a geometric modifier describing the point furthest from the point of attachment to the body or to some point of origin. For example, distal end of femur. (Experimental Factor Ontology, EFO_0001655)
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Genes

417 genes co-occuring with the biological term distal in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AARS alanyl-tRNA synthetase
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACKR2 atypical chemokine receptor 2
ADD1 adducin 1 (alpha)
ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide
ADIPOQ adiponectin, C1Q and collagen domain containing
ADRA1A adrenoceptor alpha 1A
ADRA1B adrenoceptor alpha 1B
ADRA1D adrenoceptor alpha 1D
ADRB2 adrenoceptor beta 2, surface
AIMP1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1
ALK anaplastic lymphoma receptor tyrosine kinase
AMACR alpha-methylacyl-CoA racemase
AMPD3 adenosine monophosphate deaminase 3
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
ANO5 anoctamin 5
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2
APC adenomatous polyposis coli
APOA4 apolipoprotein A-IV
AR androgen receptor
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ARRB1 arrestin, beta 1
ARRB2 arrestin, beta 2
ASS1 argininosuccinate synthase 1
ATF1 activating transcription factor 1
ATM ATM serine/threonine kinase
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4
ATP6V1B1 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1
ATP7A ATPase, Cu++ transporting, alpha polypeptide
ATR ATR serine/threonine kinase
AURKA aurora kinase A
AURKB aurora kinase B
AVPR2 arginine vasopressin receptor 2
BACE1 beta-site APP-cleaving enzyme 1
BACE2 beta-site APP-cleaving enzyme 2
BAG3 BCL2-associated athanogene 3
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BIRC5 baculoviral IAP repeat containing 5
BMP2 bone morphogenetic protein 2
BMP7 bone morphogenetic protein 7
BNC2 basonuclin 2
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA1 breast cancer 1, early onset
BRD4 bromodomain containing 4
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
C2CD3 C2 calcium-dependent domain containing 3
C5AR1 complement component 5a receptor 1
C5AR2 complement component 5a receptor 2
CA1 carbonic anhydrase I
CA2 carbonic anhydrase II
CASR calcium-sensing receptor
CAV3 caveolin 3
CBR3 carbonyl reductase 3
CCL17 chemokine (C-C motif) ligand 17
CCL2 chemokine (C-C motif) ligand 2
CCL5 chemokine (C-C motif) ligand 5
CD2 CD2 molecule
CD34 CD34 molecule
CD3E CD3e molecule, epsilon (CD3-TCR complex)
CD44 CD44 molecule (Indian blood group)
CD52 CD52 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEP162 centrosomal protein 162kDa
CEP164 centrosomal protein 164kDa
CEP83 centrosomal protein 83kDa
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHCHD4 coiled-coil-helix-coiled-coil-helix domain containing 4
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
CHRM3 cholinergic receptor, muscarinic 3
CIITA class II, major histocompatibility complex, transactivator
CISD1 CDGSH iron sulfur domain 1
CLDN2 claudin 2
CLDN8 claudin 8
CNR1 cannabinoid receptor 1 (brain)
COL17A1 collagen, type XVII, alpha 1
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
COMT catechol-O-methyltransferase
CREB1 cAMP responsive element binding protein 1
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CRP C-reactive protein, pentraxin-related
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CUL3 cullin 3
CXADR coxsackie virus and adenovirus receptor
CXCL8 chemokine (C-X-C motif) ligand 8
CYGB cytoglobin
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
DAZ3 deleted in azoospermia 3
DAZ4 deleted in azoospermia 4
DEFB1 defensin, beta 1
DEFB107A defensin, beta 107A
DEFB108P2 defensin, beta 108, pseudogene 2
DEFB4A defensin, beta 4A
DES desmin
DMD dystrophin
DSPP dentin sialophosphoprotein
DUX4L1 double homeobox 4 like 1
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1
DYSF dysferlin
E2F1 E2F transcription factor 1
ECEL1 endothelin converting enzyme-like 1
EDN1 endothelin 1
EGFR epidermal growth factor receptor
EGR1 early growth response 1
ELANE elastase, neutrophil expressed
ELK1 ELK1, member of ETS oncogene family
ELN elastin
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EPO erythropoietin
ERBB2 erb-b2 receptor tyrosine kinase 2
ERRFI1 ERBB receptor feedback inhibitor 1
ESR1 estrogen receptor 1
F2 coagulation factor II (thrombin)
F2R coagulation factor II (thrombin) receptor
F5 coagulation factor V (proaccelerin, labile factor)
F8 coagulation factor VIII, procoagulant component
FAS Fas cell surface death receptor
FGF23 fibroblast growth factor 23
FGFR4 fibroblast growth factor receptor 4
FHIT fragile histidine triad
FKBP5 FK506 binding protein 5
FLNA filamin A, alpha
FLNC filamin C, gamma
FOXA1 forkhead box A1
FOXO3 forkhead box O3
FOXO4 forkhead box O4
FXYD2 FXYD domain containing ion transport regulator 2
GARS glycyl-tRNA synthetase
GATA2 GATA binding protein 2
GCG glucagon
GCKR glucokinase (hexokinase 4) regulator
GCLC glutamate-cysteine ligase, catalytic subunit
GFER growth factor, augmenter of liver regeneration
GH2 growth hormone 2
GHR growth hormone receptor
GHSR growth hormone secretagogue receptor
GIP gastric inhibitory polypeptide
GJA1 gap junction protein, alpha 1, 43kDa
GJC2 gap junction protein, gamma 2, 47kDa
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
GPC3 glypican 3
GREB1 growth regulation by estrogen in breast cancer 1
GSTA1 glutathione S-transferase alpha 1
GSTA2 glutathione S-transferase alpha 2
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
H19 H19, imprinted maternally expressed transcript (non-protein coding)
HAND2 heart and neural crest derivatives expressed 2
HBA2 hemoglobin, alpha 2
HBB hemoglobin, beta
HCRTR2 hypocretin (orexin) receptor 2
HES1 hes family bHLH transcription factor 1
HIC2 hypermethylated in cancer 2
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HINT1 histidine triad nucleotide binding protein 1
HMOX1 heme oxygenase 1
HMOX2 heme oxygenase 2
HNF1A HNF1 homeobox A
HNF1B HNF1 homeobox B
HNF4A hepatocyte nuclear factor 4, alpha
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HNRNPK heterogeneous nuclear ribonucleoprotein K
HRAS Harvey rat sarcoma viral oncogene homolog
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
HSPA1A heat shock 70kDa protein 1A
HSPB1 heat shock 27kDa protein 1
HSPB2 heat shock 27kDa protein 2
HSPB8 heat shock 22kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HTRA2 HtrA serine peptidase 2
HTT huntingtin
ICAM1 intercellular adhesion molecule 1
IFNG interferon, gamma
IFNL3 interferon, lambda 3
IGHMBP2 immunoglobulin mu binding protein 2
IL10 interleukin 10
IL17A interleukin 17A
IL18 interleukin 18
IL1B interleukin 1, beta
IL1RAPL1 interleukin 1 receptor accessory protein-like 1
IL2 interleukin 2
IL6 interleukin 6
INSR insulin receptor
ITGA1 integrin, alpha 1
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
ITGA8 integrin, alpha 8
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITGB6 integrin, beta 6
IVL involucrin
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUND jun D proto-oncogene
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10
KCNK12 potassium channel, two pore domain subfamily K, member 12
KCNK13 potassium channel, two pore domain subfamily K, member 13
KCNQ2 potassium channel, voltage gated KQT-like subfamily Q, member 2
KIF2A kinesin heavy chain member 2A
KIR2DL2 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
KL klotho
KLF4 Kruppel-like factor 4 (gut)
KLHL3 kelch-like family member 3
KLHL9 kelch-like family member 9
KLK1 kallikrein 1
KLRD1 killer cell lectin-like receptor subfamily D, member 1
KMT2E lysine (K)-specific methyltransferase 2E
KRAS Kirsten rat sarcoma viral oncogene homolog
L1CAM L1 cell adhesion molecule
LAMA5 laminin, alpha 5
LCAT lecithin-cholesterol acyltransferase
LCK LCK proto-oncogene, Src family tyrosine kinase
LCMT2 leucine carboxyl methyltransferase 2
LCN2 lipocalin 2
LCT lactase
LEF1 lymphoid enhancer-binding factor 1
LEP leptin
LGALS3 lectin, galactoside-binding, soluble, 3
LHX3 LIM homeobox 3
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
LMNA lamin A/C
LPL lipoprotein lipase
LRP2 low density lipoprotein receptor-related protein 2
LRRC3DN LRRC3 downstream neighbor (non-protein coding)
MAG myelin associated glycoprotein
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MATR3 matrin 3
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MECOM MDS1 and EVI1 complex locus
MECP2 methyl CpG binding protein 2
MEN1 multiple endocrine neoplasia I
MFN2 mitofusin 2
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
MMP1 matrix metallopeptidase 1
MMP11 matrix metallopeptidase 11
MMP13 matrix metallopeptidase 13
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MRI1 methylthioribose-1-phosphate isomerase 1
MST1R macrophage stimulating 1 receptor
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MUC2 mucin 2, oligomeric mucus/gel-forming
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MUC5B mucin 5B, oligomeric mucus/gel-forming
MUSK muscle, skeletal, receptor tyrosine kinase
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic
MYH7 myosin, heavy chain 7, cardiac muscle, beta
MYH8 myosin, heavy chain 8, skeletal muscle, perinatal
MYOD1 myogenic differentiation 1
MYOT myotilin
NEB nebulin
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NGB neuroglobin
NGF nerve growth factor (beta polypeptide)
NKX6-1 NK6 homeobox 1
NOTCH4 notch 4
NPPC natriuretic peptide C
NPR2 natriuretic peptide receptor 2
NQO1 NAD(P)H dehydrogenase, quinone 1
NR1H4 nuclear receptor subfamily 1, group H, member 4
NR1I2 nuclear receptor subfamily 1, group I, member 2
NR1I3 nuclear receptor subfamily 1, group I, member 3
NR3C2 nuclear receptor subfamily 3, group C, member 2
NTF3 neurotrophin 3
NUMA1 nuclear mitotic apparatus protein 1
OCLN occludin
OFD1 oral-facial-digital syndrome 1
ORM1 orosomucoid 1
ORM2 orosomucoid 2
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PACSIN1 protein kinase C and casein kinase substrate in neurons 1
PARP1 poly (ADP-ribose) polymerase 1
PAXBP1 PAX3 and PAX7 binding protein 1
PC pyruvate carboxylase
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
PDK2 pyruvate dehydrogenase kinase, isozyme 2
PGR progesterone receptor
PHLDB2 pleckstrin homology-like domain, family B, member 2
PIEZO2 piezo-type mechanosensitive ion channel component 2
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIM3 Pim-3 proto-oncogene, serine/threonine kinase
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLEC plectin
PLP1 proteolipid protein 1
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRKCA protein kinase C, alpha
PROKR2 prokineticin receptor 2
PROS1 protein S (alpha)
PTEN phosphatase and tensin homolog
PTF1A pancreas specific transcription factor, 1a
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGES prostaglandin E synthase
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAB17 RAB17, member RAS oncogene family
RAB7A RAB7A, member RAS oncogene family
RAN RAN, member RAS oncogene family
RBM5 RNA binding motif protein 5
RET ret proto-oncogene
RHBG Rh family, B glycoprotein (gene/pseudogene)
RHCG Rh family, C glycoprotein
RHOB ras homolog family member B
RNU1-1 RNA, U1 small nuclear 1
ROR2 receptor tyrosine kinase-like orphan receptor 2
RUNX1 runt-related transcription factor 1
RUNX2 runt-related transcription factor 2
RWDD2B RWD domain containing 2B
SCN5A sodium channel, voltage gated, type V alpha subunit
SCN9A sodium channel, voltage gated, type IX alpha subunit
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCNN1G sodium channel, non voltage gated 1 gamma subunit
SDC1 syndecan 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)
SGK1 serum/glucocorticoid regulated kinase 1
SH2B2 SH2B adaptor protein 2
SHH sonic hedgehog
SHOX short stature homeobox
SIN3A SIN3 transcription regulator family member A
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3
SLC15A1 solute carrier family 15 (oligopeptide transporter), member 1
SLC18A3 solute carrier family 18 (vesicular acetylcholine transporter), member 3
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC26A6 solute carrier family 26 (anion exchanger), member 6
SLC26A7 solute carrier family 26 (anion exchanger), member 7
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC2A12 solute carrier family 2 (facilitated glucose transporter), member 12
SLC43A2 solute carrier family 43 (amino acid system L transporter), member 2
SLC46A1 solute carrier family 46 (folate transporter), member 1
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group)
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SLC9B2 solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNTN sentan, cilia apical structure protein
SOS1 son of sevenless homolog 1 (Drosophila)
SOX9 SRY (sex determining region Y)-box 9
SP1 Sp1 transcription factor
SPI1 Spi-1 proto-oncogene
SPP1 secreted phosphoprotein 1
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3
SRPK1 SRSF protein kinase 1
SRSF1 serine/arginine-rich splicing factor 1
SSTR3 somatostatin receptor 3
ST2 suppression of tumorigenicity 2
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT5A signal transducer and activator of transcription 5A
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
T T, brachyury homolog (mouse)
TBX1 T-box 1
TBX21 T-box 21
TF transferrin
TGFB1 transforming growth factor, beta 1
TGFB3 transforming growth factor, beta 3
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TIA1 TIA1 cytotoxic granule-associated RNA binding protein
TICAM1 toll-like receptor adaptor molecule 1
TMSB10 thymosin beta 10
TNF tumor necrosis factor
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TNIP1 TNFAIP3 interacting protein 1
TNNI2 troponin I type 2 (skeletal, fast)
TOX3 TOX high mobility group box family member 3
TP53 tumor protein p53
TPM2 tropomyosin 2 (beta)
TRPM6 transient receptor potential cation channel, subfamily M, member 6
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TRPV4 transient receptor potential cation channel, subfamily V, member 4
TRPV5 transient receptor potential cation channel, subfamily V, member 5
TRPV6 transient receptor potential cation channel, subfamily V, member 6
TTBK2 tau tubulin kinase 2
TTN titin
TYMS thymidylate synthetase
TYRP1 tyrosinase-related protein 1
UGDH UDP-glucose 6-dehydrogenase
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1
UMOD uromodulin
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
VCP valosin containing protein
VEGFA vascular endothelial growth factor A
VMA21 VMA21 vacuolar H+-ATPase homolog (S. cerevisiae)
WDR11 WD repeat domain 11
WNK1 WNK lysine deficient protein kinase 1
WNK3 WNK lysine deficient protein kinase 3
WNT3 wingless-type MMTV integration site family, member 3
ZBTB5 zinc finger and BTB domain containing 5
ZBTB7B zinc finger and BTB domain containing 7B
ZNF148 zinc finger protein 148