disopyramide-7276 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the disopyramide-7276 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
AIM2 absent in melanoma 2
ANP32A-IT1 ANP32A intronic transcript 1
AP4S1 adaptor-related protein complex 4, sigma 1 subunit
ATP11A ATPase, class VI, type 11A
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
ATRX alpha thalassemia/mental retardation syndrome X-linked
CFLAR CASP8 and FADD-like apoptosis regulator
CLCA1 chloride channel accessory 1
CNIH3 cornichon family AMPA receptor auxiliary protein 3
COL3A1 collagen, type III, alpha 1
CSPP1 centrosome and spindle pole associated protein 1
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae)
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
DNAAF2 dynein, axonemal, assembly factor 2
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4
DNAL4 dynein, axonemal, light chain 4
DRP2 dystrophin related protein 2
EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3
EN2 engrailed homeobox 2
ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4
FGF2 fibroblast growth factor 2 (basic)
FGF5 fibroblast growth factor 5
GABARAPL1 GABA(A) receptor-associated protein like 1
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
GRM8 glutamate receptor, metabotropic 8
GTPBP4 GTP binding protein 4
HDAC9 histone deacetylase 9
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4
HES2 hes family bHLH transcription factor 2
HIRA histone cell cycle regulator
HIST1H1D histone cluster 1, H1d
IFIH1 interferon induced with helicase C domain 1
INPP5B inositol polyphosphate-5-phosphatase, 75kDa
KAT6A K(lysine) acetyltransferase 6A
KIAA0232 KIAA0232
KLF12 Kruppel-like factor 12
LMAN1 lectin, mannose-binding, 1
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LY6G6C lymphocyte antigen 6 complex, locus G6C
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAPK14 mitogen-activated protein kinase 14
METTL16 methyltransferase like 16
MIS18BP1 MIS18 binding protein 1
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MPZL1 myelin protein zero-like 1
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NCKAP1 NCK-associated protein 1
NELFA negative elongation factor complex member A
NOTCH1 notch 1
NRXN3 neurexin 3
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
PDE11A phosphodiesterase 11A
PDS5A PDS5 cohesin associated factor A
PER1 period circadian clock 1
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PRB1 proline-rich protein BstNI subfamily 1
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2
PTPRF protein tyrosine phosphatase, receptor type, F
R3HDM1 R3H domain containing 1
RDX radixin
RGS5 regulator of G-protein signaling 5
RNF19B ring finger protein 19B
RPAIN RPA interacting protein
RPL35A ribosomal protein L35a
SEC23IP SEC23 interacting protein
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SMG6 SMG6 nonsense mediated mRNA decay factor
SMG7 SMG7 nonsense mediated mRNA decay factor
SNAPC3 small nuclear RNA activating complex, polypeptide 3, 50kDa
SPATA2L spermatogenesis associated 2-like
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
TAZ tafazzin
TBX10 T-box 10
THRA thyroid hormone receptor, alpha
TNC tenascin C
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TRAPPC13 trafficking protein particle complex 13
TTLL7 tubulin tyrosine ligase-like family member 7
UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast)
WDR33 WD repeat domain 33
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1
WNT7A wingless-type MMTV integration site family, member 7A
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
ZFYVE9 zinc finger, FYVE domain containing 9
ZMYM5 zinc finger, MYM-type 5
ZNF174 zinc finger protein 174
ZNF253 zinc finger protein 253
ZNF358 zinc finger protein 358
ZNF551 zinc finger protein 551
ZNF580 zinc finger protein 580
ZNF675 zinc finger protein 675
ZNF778 zinc finger protein 778
ZNF79 zinc finger protein 79

decreased expression

Symbol Name
ACADSB acyl-CoA dehydrogenase, short/branched chain
ACTG2 actin, gamma 2, smooth muscle, enteric
AFAP1 actin filament associated protein 1
ANKEF1 ankyrin repeat and EF-hand domain containing 1
ANKFY1 ankyrin repeat and FYVE domain containing 1
APH1B APH1B gamma secretase subunit
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
AXIN1 axin 1
BEX4 brain expressed, X-linked 4
BGLAP bone gamma-carboxyglutamate (gla) protein
C1ORF115 chromosome 1 open reading frame 115
C4ORF19 chromosome 4 open reading frame 19
CARD8 caspase recruitment domain family, member 8
CCNO cyclin O
CENPT centromere protein T
CLSPN claspin
COLGALT2 collagen beta(1-O)galactosyltransferase 2
CPA4 carboxypeptidase A4
CTSK cathepsin K
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
DBF4B DBF4 zinc finger B
DGKZ diacylglycerol kinase, zeta
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
DLL3 delta-like 3 (Drosophila)
EDC3 enhancer of mRNA decapping 3
EDC4 enhancer of mRNA decapping 4
EPHA4 EPH receptor A4
EVPL envoplakin
FAM222B family with sequence similarity 222, member B
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FSTL3 follistatin-like 3 (secreted glycoprotein)
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HLX H2.0-like homeobox
HMHA1 histocompatibility (minor) HA-1
IFI30 interferon, gamma-inducible protein 30
KIAA1462 KIAA1462
KLHL36 kelch-like family member 36
LMBR1L limb development membrane protein 1-like
LONRF3 LON peptidase N-terminal domain and ring finger 3
LPAR4 lysophosphatidic acid receptor 4
LPCAT1 lysophosphatidylcholine acyltransferase 1
LRRC49 leucine rich repeat containing 49
MAMLD1 mastermind-like domain containing 1
MANBA mannosidase, beta A, lysosomal
MCM9 minichromosome maintenance complex component 9
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MICALL2 MICAL-like 2
MT1F metallothionein 1F
NADSYN1 NAD synthetase 1
NDE1 nudE neurodevelopment protein 1
NKX3-2 NK3 homeobox 2
NUBP2 nucleotide binding protein 2
OCLN occludin
ORC1 origin recognition complex, subunit 1
OSBP2 oxysterol binding protein 2
PDE8B phosphodiesterase 8B
PHC1 polyhomeotic homolog 1 (Drosophila)
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PLEKHJ1 pleckstrin homology domain containing, family J member 1
POU2F1 POU class 2 homeobox 1
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
PRKX protein kinase, X-linked
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RIN1 Ras and Rab interactor 1
RNF123 ring finger protein 123
RPAP1 RNA polymerase II associated protein 1
RPL7A ribosomal protein L7a
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae)
SERINC5 serine incorporator 5
SFMBT1 Scm-like with four mbt domains 1
SLC12A8 solute carrier family 12, member 8
SOX12 SRY (sex determining region Y)-box 12
STARD13 StAR-related lipid transfer (START) domain containing 13
SUGP1 SURP and G patch domain containing 1
TBC1D12 TBC1 domain family, member 12
TMCC2 transmembrane and coiled-coil domain family 2
TMEM121 transmembrane protein 121
TMEM51 transmembrane protein 51
TNNI3 troponin I type 3 (cardiac)
TRAF5 TNF receptor-associated factor 5
TRIM45 tripartite motif containing 45
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TTC26 tetratricopeptide repeat domain 26
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
USB1 U6 snRNA biogenesis 1
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
WDR46 WD repeat domain 46
ZBTB39 zinc finger and BTB domain containing 39
ZNF177 zinc finger protein 177
ZNF227 zinc finger protein 227
ZNF696 zinc finger protein 696
ZNF701 zinc finger protein 701
ZNF85 zinc finger protein 85