diprophylline-5063 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the diprophylline-5063 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AGO4 argonaute RISC catalytic component 4
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
ARHGAP35 Rho GTPase activating protein 35
ARMCX4 armadillo repeat containing, X-linked 4
ASTN2 astrotactin 2
ATF6B activating transcription factor 6 beta
ATP10B ATPase, class V, type 10B
BAZ1B bromodomain adjacent to zinc finger domain, 1B
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit
CCDC85C coiled-coil domain containing 85C
CD3D CD3d molecule, delta (CD3-TCR complex)
CDC14A cell division cycle 14A
CEND1 cell cycle exit and neuronal differentiation 1
CISH cytokine inducible SH2-containing protein
CLUAP1 clusterin associated protein 1
COL3A1 collagen, type III, alpha 1
COQ7 coenzyme Q7 homolog, ubiquinone (yeast)
CPZ carboxypeptidase Z
CREBZF CREB/ATF bZIP transcription factor
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34
DOCK10 dedicator of cytokinesis 10
DOCK9 dedicator of cytokinesis 9
ECM1 extracellular matrix protein 1
EFNB1 ephrin-B1
FAM174B family with sequence similarity 174, member B
FBN2 fibrillin 2
FBXO21 F-box protein 21
FGF6 fibroblast growth factor 6
FGL2 fibrinogen-like 2
FKBP10 FK506 binding protein 10, 65 kDa
FLT3LG fms-related tyrosine kinase 3 ligand
FRMD4A FERM domain containing 4A
GAN gigaxonin
GDF2 growth differentiation factor 2
GPATCH4 G patch domain containing 4
GRB7 growth factor receptor-bound protein 7
GSK3A glycogen synthase kinase 3 alpha
GULP1 GULP, engulfment adaptor PTB domain containing 1
HAP1 huntingtin-associated protein 1
HEATR6 HEAT repeat containing 6
HIP1 huntingtin interacting protein 1
INO80D INO80 complex subunit D
KITLG KIT ligand
KLHL25 kelch-like family member 25
LAG3 lymphocyte-activation gene 3
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAPK10 mitogen-activated protein kinase 10
MATN3 matrilin 3
MST1 macrophage stimulating 1
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTNR1A melatonin receptor 1A
MYO1B myosin IB
MYOZ1 myozenin 1
NAV3 neuron navigator 3
PDE4C phosphodiesterase 4C, cAMP-specific
PDE4DIP phosphodiesterase 4D interacting protein
PER1 period circadian clock 1
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLXNC1 plexin C1
PODXL2 podocalyxin-like 2
PRF1 perforin 1 (pore forming protein)
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTGDR2 prostaglandin D2 receptor 2
RAB26 RAB26, member RAS oncogene family
RAB28 RAB28, member RAS oncogene family
RAB3B RAB3B, member RAS oncogene family
RASA3 RAS p21 protein activator 3
RPL10 ribosomal protein L10
RXRB retinoid X receptor, beta
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
SENP7 SUMO1/sentrin specific peptidase 7
SIRPA signal-regulatory protein alpha
SLC9A7 solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7
SLCO1C1 solute carrier organic anion transporter family, member 1C1
SPATA1 spermatogenesis associated 1
STX16 syntaxin 16
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
TBC1D22A TBC1 domain family, member 22A
TBC1D2B TBC1 domain family, member 2B
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS3 thrombospondin 3
THY1 Thy-1 cell surface antigen
TYMS thymidylate synthetase
UBOX5 U-box domain containing 5
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
VCX2 variable charge, X-linked 2
WIPF1 WAS/WASL interacting protein family, member 1
WNT5B wingless-type MMTV integration site family, member 5B
YY1 YY1 transcription factor
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF224 zinc finger protein 224
ZNF235 zinc finger protein 235
ZNF3 zinc finger protein 3
ZNF710 zinc finger protein 710

decreased expression

Symbol Name
ABHD8 abhydrolase domain containing 8
AFAP1 actin filament associated protein 1
AK5 adenylate kinase 5
ALG12 ALG12, alpha-1,6-mannosyltransferase
ANKRD7 ankyrin repeat domain 7
APOLD1 apolipoprotein L domain containing 1
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
BZRAP1 benzodiazepine receptor (peripheral) associated protein 1
C14ORF93 chromosome 14 open reading frame 93
C22ORF46 chromosome 22 open reading frame 46
CD70 CD70 molecule
CENPO centromere protein O
CHMP6 charged multivesicular body protein 6
CHRDL1 chordin-like 1
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
CNN1 calponin 1, basic, smooth muscle
CNTNAP1 contactin associated protein 1
CPNE7 copine VII
CXORF21 chromosome X open reading frame 21
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DLK2 delta-like 2 homolog (Drosophila)
DPF3 D4, zinc and double PHD fingers, family 3
DUSP8 dual specificity phosphatase 8
EGF epidermal growth factor
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
EPB41L5 erythrocyte membrane protein band 4.1 like 5
ERCC4 excision repair cross-complementation group 4
EXOSC1 exosome component 1
FBXL7 F-box and leucine-rich repeat protein 7
FRS3 fibroblast growth factor receptor substrate 3
GAL3ST4 galactose-3-O-sulfotransferase 4
GPR1 G protein-coupled receptor 1
GUSBP3 glucuronidase, beta pseudogene 3
H2AFJ H2A histone family, member J
HIST1H2AM histone cluster 1, H2am
HIST1H2BN histone cluster 1, H2bn
HIST1H4C histone cluster 1, H4c
IL4R interleukin 4 receptor
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIAA0894 KIAA0894 protein
KIAA0895 KIAA0895
KIAA1456 KIAA1456
KLF13 Kruppel-like factor 13
KRT34 keratin 34, type I
LRP3 low density lipoprotein receptor-related protein 3
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MAP3K7CL MAP3K7 C-terminal like
MBL1P mannose-binding lectin (protein A) 1, pseudogene
MED31 mediator complex subunit 31
MFSD12 major facilitator superfamily domain containing 12
MUC2 mucin 2, oligomeric mucus/gel-forming
MXD3 MAX dimerization protein 3
MYL9 myosin, light chain 9, regulatory
NHEJ1 nonhomologous end-joining factor 1
NOL6 nucleolar protein 6 (RNA-associated)
PARD6A par-6 family cell polarity regulator alpha
PCDHGB5 protocadherin gamma subfamily B, 5
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6
POLH polymerase (DNA directed), eta
PRPH peripherin
PRSS53 protease, serine, 53
RGL2 ral guanine nucleotide dissociation stimulator-like 2
RGS19 regulator of G-protein signaling 19
RIBC2 RIB43A domain with coiled-coils 2
RPL23AP32 ribosomal protein L23a pseudogene 32
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
RSF1 remodeling and spacing factor 1
SAYSD1 SAYSVFN motif domain containing 1
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SEPP1 selenoprotein P, plasma, 1
SLC35F6 solute carrier family 35, member F6
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SMAD7 SMAD family member 7
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SNPH syntaphilin
STAG3 stromal antigen 3
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STARD3 StAR-related lipid transfer (START) domain containing 3
STRA6 stimulated by retinoic acid 6
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TINAGL1 tubulointerstitial nephritis antigen-like 1
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TSC22D4 TSC22 domain family, member 4
TSKU tsukushi, small leucine rich proteoglycan
TUBA3C tubulin, alpha 3c
USP27X ubiquitin specific peptidase 27, X-linked
ZFHX3 zinc finger homeobox 3
ZFP30 ZFP30 zinc finger protein
ZFP36 ZFP36 ring finger protein
ZNF141 zinc finger protein 141
ZNF276 zinc finger protein 276
ZNF33B zinc finger protein 33B
ZNF770 zinc finger protein 770