dimethadione-3367 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the dimethadione-3367 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM22 ADAM metallopeptidase domain 22
ADAM8 ADAM metallopeptidase domain 8
AKAP6 A kinase (PRKA) anchor protein 6
AKAP8L A kinase (PRKA) anchor protein 8-like
ANGPTL2 angiopoietin-like 2
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
APAF1 apoptotic peptidase activating factor 1
ATP11A ATPase, class VI, type 11A
BCL2L10 BCL2-like 10 (apoptosis facilitator)
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
BTF3P11 basic transcription factor 3 pseudogene 11
C1QTNF1 C1q and tumor necrosis factor related protein 1
C22ORF46 chromosome 22 open reading frame 46
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CAV3 caveolin 3
CCRL2 chemokine (C-C motif) receptor-like 2
CD47 CD47 molecule
CD5 CD5 molecule
CD6 CD6 molecule
CDHR2 cadherin-related family member 2
CROCCP3 ciliary rootlet coiled-coil, rootletin pseudogene 3
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12
CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2
DAPK2 death-associated protein kinase 2
DCBLD2 discoidin, CUB and LCCL domain containing 2
DCN decorin
DHRS7 dehydrogenase/reductase (SDR family) member 7
EFHC2 EF-hand domain (C-terminal) containing 2
ELL elongation factor RNA polymerase II
ENO3 enolase 3 (beta, muscle)
EPYC epiphycan
F13A1 coagulation factor XIII, A1 polypeptide
FBLN1 fibulin 1
FLRT2 fibronectin leucine rich transmembrane protein 2
FRMD1 FERM domain containing 1
FRMD4A FERM domain containing 4A
FXYD5 FXYD domain containing ion transport regulator 5
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GPR20 G protein-coupled receptor 20
GRM8 glutamate receptor, metabotropic 8
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
HCG4 HLA complex group 4 (non-protein coding)
HNF1A HNF1 homeobox A
IFI44 interferon-induced protein 44
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
INHBA inhibin, beta A
IPW imprinted in Prader-Willi syndrome (non-protein coding)
IRF4 interferon regulatory factor 4
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KLK13 kallikrein-related peptidase 13
KREMEN2 kringle containing transmembrane protein 2
LDLR low density lipoprotein receptor
LRRN3 leucine rich repeat neuronal 3
MBD2 methyl-CpG binding domain protein 2
MBNL2 muscleblind-like splicing regulator 2
MEF2C myocyte enhancer factor 2C
MFAP5 microfibrillar associated protein 5
MIER2 mesoderm induction early response 1, family member 2
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MST1 macrophage stimulating 1
MYO9B myosin IXB
MYOZ3 myozenin 3
NCLN nicalin
NKX2-5 NK2 homeobox 5
NOX5 NADPH oxidase, EF-hand calcium binding domain 5
NPR2 natriuretic peptide receptor 2
NTF3 neurotrophin 3
NTNG1 netrin G1
NUP88 nucleoporin 88kDa
OCA2 oculocutaneous albinism II
OR10H1 olfactory receptor, family 10, subfamily H, member 1
OVGP1 oviductal glycoprotein 1, 120kDa
PCDHB12 protocadherin beta 12
PCDHGA3 protocadherin gamma subfamily A, 3
PLLP plasmolipin
PLXNA2 plexin A2
PRDX2 peroxiredoxin 2
PYY peptide YY
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPS4Y1 ribosomal protein S4, Y-linked 1
SCAND2P SCAN domain containing 2 pseudogene
SH3BP2 SH3-domain binding protein 2
SIGLEC7 sialic acid binding Ig-like lectin 7
SIGLEC8 sialic acid binding Ig-like lectin 8
SIRT5 sirtuin 5
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
SLC45A2 solute carrier family 45, member 2
STEAP4 STEAP family member 4
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa
TAGLN3 transgelin 3
TM4SF1 transmembrane 4 L six family member 1
TMCC2 transmembrane and coiled-coil domain family 2
TNK2 tyrosine kinase, non-receptor, 2
TSPAN32 tetraspanin 32
USH1C Usher syndrome 1C (autosomal recessive, severe)
USP2 ubiquitin specific peptidase 2
WIPI2 WD repeat domain, phosphoinositide interacting 2

decreased expression

Symbol Name
ABI3BP ABI family, member 3 (NESH) binding protein
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
C11ORF80 chromosome 11 open reading frame 80
CAMK4 calcium/calmodulin-dependent protein kinase IV
CCNO cyclin O
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CGA glycoprotein hormones, alpha polypeptide
CLSPN claspin
CNKSR1 connector enhancer of kinase suppressor of Ras 1
COPZ2 coatomer protein complex, subunit zeta 2
CRIP1 cysteine-rich protein 1 (intestinal)
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11
DCAF4 DDB1 and CUL4 associated factor 4
DEAF1 DEAF1 transcription factor
DGAT1 diacylglycerol O-acyltransferase 1
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DYSF dysferlin
EHMT1 euchromatic histone-lysine N-methyltransferase 1
ELOVL4 ELOVL fatty acid elongase 4
ERN2 endoplasmic reticulum to nucleus signaling 2
F2R coagulation factor II (thrombin) receptor
FAM212B family with sequence similarity 212, member B
FAM86C1 family with sequence similarity 86, member C1
FGL1 fibrinogen-like 1
GADD45G growth arrest and DNA-damage-inducible, gamma
GLB1L galactosidase, beta 1-like
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPR143 G protein-coupled receptor 143
GPR21 G protein-coupled receptor 21
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GPX2 glutathione peroxidase 2
HIST1H2AJ histone cluster 1, H2aj
HIST1H3B histone cluster 1, H3b
HMOX1 heme oxygenase 1
HOXC5 homeobox C5
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
IQCG IQ motif containing G
IRAK4 interleukin-1 receptor-associated kinase 4
KCNK12 potassium channel, two pore domain subfamily K, member 12
KCNK5 potassium channel, two pore domain subfamily K, member 5
KCTD17 potassium channel tetramerization domain containing 17
KCTD7 potassium channel tetramerization domain containing 7
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LHX6 LIM homeobox 6
LOC100287590 uncharacterized LOC100287590
LRRC37A3 leucine rich repeat containing 37, member A3
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
LYRM9 LYR motif containing 9
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAPK10 mitogen-activated protein kinase 10
MAST3 microtubule associated serine/threonine kinase 3
MBTD1 mbt domain containing 1
MEFV Mediterranean fever
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MUM1 melanoma associated antigen (mutated) 1
MYO1F myosin IF
NKX3-2 NK3 homeobox 2
NME5 NME/NM23 family member 5
NOD1 nucleotide-binding oligomerization domain containing 1
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
OGFRL1 opioid growth factor receptor-like 1
OSGIN1 oxidative stress induced growth inhibitor 1
PADI1 peptidyl arginine deiminase, type I
PARP16 poly (ADP-ribose) polymerase family, member 16
PCDHA6 protocadherin alpha 6
PDE12 phosphodiesterase 12
PDIA3 protein disulfide isomerase family A, member 3
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PEX26 peroxisomal biogenesis factor 26
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
R3HCC1L R3H domain and coiled-coil containing 1-like
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
RHBG Rh family, B glycoprotein (gene/pseudogene)
SCML2 sex comb on midleg-like 2 (Drosophila)
SCN1B sodium channel, voltage gated, type I beta subunit
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SP140L SP140 nuclear body protein-like
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPRY2 sprouty homolog 2 (Drosophila)
STIM1 stromal interaction molecule 1
STK25 serine/threonine kinase 25
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TBC1D2 TBC1 domain family, member 2
TET3 tet methylcytosine dioxygenase 3
TICAM1 toll-like receptor adaptor molecule 1
TMEM183A transmembrane protein 183A
TMEM254 transmembrane protein 254
TMPRSS4 transmembrane protease, serine 4
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
WDR78 WD repeat domain 78
ZNF446 zinc finger protein 446
ZNF701 zinc finger protein 701
ZNF816 zinc finger protein 816