dicycloverine-4581 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the dicycloverine-4581 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AFF4 AF4/FMR2 family, member 4
AKAP11 A kinase (PRKA) anchor protein 11
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
BCAS1 breast carcinoma amplified sequence 1
BIRC3 baculoviral IAP repeat containing 3
BMP4 bone morphogenetic protein 4
BTG2 BTG family, member 2
C10ORF12 chromosome 10 open reading frame 12
CAMKMT calmodulin-lysine N-methyltransferase
CANX calnexin
CCDC85B coiled-coil domain containing 85B
CD1C CD1c molecule
CD47 CD47 molecule
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CGA glycoprotein hormones, alpha polypeptide
CIZ1 CDKN1A interacting zinc finger protein 1
CLCN4 chloride channel, voltage-sensitive 4
CLCN6 chloride channel, voltage-sensitive 6
CLDN1 claudin 1
CLSPN claspin
COBLL1 cordon-bleu WH2 repeat protein-like 1
CREM cAMP responsive element modulator
CTAGE5 CTAGE family, member 5
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DENND3 DENN/MADD domain containing 3
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DUSP5 dual specificity phosphatase 5
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNB3 ephrin-B3
EFR3B EFR3 homolog B (S. cerevisiae)
EGLN3 egl-9 family hypoxia-inducible factor 3
ERAP1 endoplasmic reticulum aminopeptidase 1
FGL1 fibrinogen-like 1
FLT1 fms-related tyrosine kinase 1
FOXG1 forkhead box G1
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
GABARAPL1 GABA(A) receptor-associated protein like 1
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GPC3 glypican 3
GREM1 gremlin 1, DAN family BMP antagonist
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HTR7P1 5-hydroxytryptamine (serotonin) receptor 7 pseudogene 1
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
ICOSLG inducible T-cell co-stimulator ligand
IGHA1 immunoglobulin heavy constant alpha 1
ING4 inhibitor of growth family, member 4
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KRT6B keratin 6B, type II
LRRC2 leucine rich repeat containing 2
MAP2K3 mitogen-activated protein kinase kinase 3
MAPK11 mitogen-activated protein kinase 11
MAX MYC associated factor X
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NAV3 neuron navigator 3
NFRKB nuclear factor related to kappaB binding protein
NRG1 neuregulin 1
PAOX polyamine oxidase (exo-N4-amino)
PCDHB17P protocadherin beta 17 pseudogene
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCSK6 proprotein convertase subtilisin/kexin type 6
PDGFB platelet-derived growth factor beta polypeptide
PHF14 PHD finger protein 14
PHF20 PHD finger protein 20
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PMCHL1 pro-melanin-concentrating hormone-like 1, pseudogene
PPIAL4A peptidylprolyl isomerase A (cyclophilin A)-like 4A
PQBP1 polyglutamine binding protein 1
PTAFR platelet-activating factor receptor
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPRH protein tyrosine phosphatase, receptor type, H
RAB28 RAB28, member RAS oncogene family
RPL13 ribosomal protein L13
SAMD4A sterile alpha motif domain containing 4A
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SNRK SNF related kinase
SOGA1 suppressor of glucose, autophagy associated 1
SPRR1A small proline-rich protein 1A
SPTBN1 spectrin, beta, non-erythrocytic 1
SRRT serrate, RNA effector molecule
TAS2R1 taste receptor, type 2, member 1
TBC1D30 TBC1 domain family, member 30
TGFB2 transforming growth factor, beta 2
THBS1 thrombospondin 1
TK2 thymidine kinase 2, mitochondrial
TMEM156 transmembrane protein 156
TMEM212 transmembrane protein 212
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TSNAXIP1 translin-associated factor X interacting protein 1
USP18 ubiquitin specific peptidase 18
VCAN versican

decreased expression

Symbol Name
ABHD8 abhydrolase domain containing 8
ACE angiotensin I converting enzyme
ADAM15 ADAM metallopeptidase domain 15
AGMAT agmatine ureohydrolase (agmatinase)
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ARL15 ADP-ribosylation factor-like 15
ARMCX2 armadillo repeat containing, X-linked 2
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BAHCC1 BAH domain and coiled-coil containing 1
BNC1 basonuclin 1
BOLA1 bolA family member 1
BSPRY B-box and SPRY domain containing
C14ORF93 chromosome 14 open reading frame 93
C3 complement component 3
CCDC85C coiled-coil domain containing 85C
CCDC9 coiled-coil domain containing 9
CDT1 chromatin licensing and DNA replication factor 1
CEL carboxyl ester lipase
CHRDL1 chordin-like 1
CINP cyclin-dependent kinase 2 interacting protein
CISH cytokine inducible SH2-containing protein
CPEB1 cytoplasmic polyadenylation element binding protein 1
DBR1 debranching RNA lariats 1
DCBLD2 discoidin, CUB and LCCL domain containing 2
EDIL3 EGF-like repeats and discoidin I-like domains 3
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
ELAVL3 ELAV like neuron-specific RNA binding protein 3
ELSPBP1 epididymal sperm binding protein 1
EPPK1 epiplakin 1
ERN2 endoplasmic reticulum to nucleus signaling 2
FBXL15 F-box and leucine-rich repeat protein 15
FLRT3 fibronectin leucine rich transmembrane protein 3
GAL3ST4 galactose-3-O-sulfotransferase 4
GLDC glycine dehydrogenase (decarboxylating)
GRTP1 growth hormone regulated TBC protein 1
HINFP histone H4 transcription factor
HIST1H2AI histone cluster 1, H2ai
HIST1H2BM histone cluster 1, H2bm
HIST2H2AA3 histone cluster 2, H2aa3
HOXA1 homeobox A1
IL17RB interleukin 17 receptor B
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
LHX6 LIM homeobox 6
LIME1 Lck interacting transmembrane adaptor 1
LMNB1 lamin B1
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
LYRM9 LYR motif containing 9
MAGEA6 melanoma antigen family A6
MBL1P mannose-binding lectin (protein A) 1, pseudogene
MBTPS2 membrane-bound transcription factor peptidase, site 2
MRPL52 mitochondrial ribosomal protein L52
MUTYH mutY homolog
NDP Norrie disease (pseudoglioma)
NKX3-2 NK3 homeobox 2
OVGP1 oviductal glycoprotein 1, 120kDa
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
PALMD palmdelphin
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PEX26 peroxisomal biogenesis factor 26
PICK1 protein interacting with PRKCA 1
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PMCH pro-melanin-concentrating hormone
PROX1 prospero homeobox 1
PRR15L proline rich 15-like
PTPRS protein tyrosine phosphatase, receptor type, S
RAB25 RAB25, member RAS oncogene family
RAB27B RAB27B, member RAS oncogene family
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RAI2 retinoic acid induced 2
RGS17 regulator of G-protein signaling 17
RRAGB Ras-related GTP binding B
S100A3 S100 calcium binding protein A3
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1
SLMO1 slowmo homolog 1 (Drosophila)
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SNX15 sorting nexin 15
SOBP sine oculis binding protein homolog (Drosophila)
SPEG SPEG complex locus
STON1 stonin 1
SYTL2 synaptotagmin-like 2
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
TENM4 teneurin transmembrane protein 4
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TMEM180 transmembrane protein 180
TSC22D4 TSC22 domain family, member 4
TSPAN1 tetraspanin 1
TSPAN2 tetraspanin 2
VGF VGF nerve growth factor inducible
ZKSCAN4 zinc finger with KRAB and SCAN domains 4
ZNF205 zinc finger protein 205
ZNF253 zinc finger protein 253
ZNF574 zinc finger protein 574
ZNF671 zinc finger protein 671
ZSCAN31 zinc finger and SCAN domain containing 31