diarrhea Gene Set

Dataset GWASdb SNP-Disease Associations
Category disease or phenotype associations
Type disease
Description A gastrointestinal system disease described as the condition of having frequent loose or liquid bowel movements. Acute diarrhea is a common cause of death in developing countries and the second most common cause of infant deaths worldwide. The loss of fluids through diarrhea can cause severe dehydration which is one cause of death in diarrhea sufferers. Along with water, sufferers also lose dangerous amounts of important salts, electrolytes, and other nutrients. There are at least four types of diarrhea: secretory diarrhea, osmotic diarrhea, motility-related diarrhea, and inflammatory diarrhea. (Human Disease Ontology, DOID_13250)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/DOID:13250
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Genes

178 genes associated with the disease diarrhea in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.

Symbol Name Standardized Value
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 1.14463
CALCR calcitonin receptor 1.05943
MALRD1 MAM and LDL receptor class A domain containing 1 1.04846
SLC51A solute carrier family 51, alpha subunit 1.02945
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin 1.00596
ZFAND4 zinc finger, AN1-type domain 4 0.989716
CNTNAP2 contactin associated protein-like 2 0.986376
SMAD6 SMAD family member 6 0.971169
CPS1 carbamoyl-phosphate synthase 1, mitochondrial 0.958374
KLHL32 kelch-like family member 32 0.958374
PTPRJ protein tyrosine phosphatase, receptor type, J 0.958374
TRAPPC9 trafficking protein particle complex 9 0.958374
APP amyloid beta (A4) precursor protein 0.958374
FRMD5 FERM domain containing 5 0.892579
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.886521
EGFR epidermal growth factor receptor 0.88034
C4ORF45 chromosome 4 open reading frame 45 0.88034
AIG1 androgen-induced 1 0.88034
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) 0.88034
C20ORF196 chromosome 20 open reading frame 196 0.88034
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1 0.88034
MAP2 microtubule-associated protein 2 0.88034
RYR2 ryanodine receptor 2 (cardiac) 0.88034
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 0.88034
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.88034
PXDNL peroxidasin-like 0.831584
CHD9 chromodomain helicase DNA binding protein 9 0.831584
ADAMTSL3 ADAMTS-like 3 0.831584
ERBB4 erb-b2 receptor tyrosine kinase 4 0.831584
PCDH9 protocadherin 9 0.831584
NRXN3 neurexin 3 0.831584
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 0.831584
ELMO1 engulfment and cell motility 1 0.831584
TPK1 thiamin pyrophosphokinase 1 0.831584
ZNF385D zinc finger protein 385D 0.831584
BMPR1B bone morphogenetic protein receptor, type IB 0.831584
ANKFN1 ankyrin-repeat and fibronectin type III domain containing 1 0.831584
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.831584
USP45 ubiquitin specific peptidase 45 0.804621
PAX2 paired box 2 0.801304
FAM207A family with sequence similarity 207, member A 0.79774
CCDC67 coiled-coil domain containing 67 0.794247
FGF12 fibroblast growth factor 12 0.794247
LPA lipoprotein, Lp(a) 0.794247
CADM1 cell adhesion molecule 1 0.794247
NRG3 neuregulin 3 0.794247
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.794247
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.794247
ALPK3 alpha-kinase 3 0.794247
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3 0.794247
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase 0.794247
SDHAF3 succinate dehydrogenase complex assembly factor 3 0.794247
PTPRD protein tyrosine phosphatase, receptor type, D 0.794247
AOX2P aldehyde oxidase 2 pseudogene 0.794247
FRMD4A FERM domain containing 4A 0.764084
LINC00540 long intergenic non-protein coding RNA 540 0.764084
DCLK1 doublecortin-like kinase 1 0.764084
ARMC8 armadillo repeat containing 8 0.764084
MEMO1 mediator of cell motility 1 0.764084
SOX5 SRY (sex determining region Y)-box 5 0.764084
COL13A1 collagen, type XIII, alpha 1 0.738669
TFEC transcription factor EC 0.738669
ESRRG estrogen-related receptor gamma 0.738669
LDB2 LIM domain binding 2 0.738669
C6ORF89 chromosome 6 open reading frame 89 0.738669
NGEF neuronal guanine nucleotide exchange factor 0.738669
FBLN1 fibulin 1 0.738669
SEZ6L seizure related 6 homolog (mouse)-like 0.738669
ASS1 argininosuccinate synthase 1 0.738669
EIF3E eukaryotic translation initiation factor 3, subunit E 0.738669
SRD5A3 steroid 5 alpha-reductase 3 0.738669
TBC1D22A TBC1 domain family, member 22A 0.720532
PRR16 proline rich 16 0.716372
GBA3 glucosidase, beta, acid 3 (gene/pseudogene) 0.716372
DOPEY1 dopey family member 1 0.716372
MACROD1 MACRO domain containing 1 0.716372
MLPH melanophilin 0.716372
LIMCH1 LIM and calponin homology domains 1 0.716372
KIAA1217 KIAA1217 0.716372
KIF13B kinesin family member 13B 0.716372
UMODL1 uromodulin-like 1 0.69773
FAM71F1 family with sequence similarity 71, member F1 0.69773
AKNAD1 AKNA domain containing 1 0.69773
HS3ST4 heparan sulfate (glucosamine) 3-O-sulfotransferase 4 0.69773
ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11 0.69773
CADM2 cell adhesion molecule 2 0.69773
LOC339862 uncharacterized LOC339862 0.69773
PCDH15 protocadherin-related 15 0.69773
SCHIP1 schwannomin interacting protein 1 0.69773
SORCS1 sortilin-related VPS10 domain containing receptor 1 0.69773
SERPINB11 serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene) 0.69773
DFNB31 deafness, autosomal recessive 31 0.683452
UBE2W ubiquitin-conjugating enzyme E2W (putative) 0.681983
ELOVL6 ELOVL fatty acid elongase 6 0.681983
SBF2 SET binding factor 2 0.681983
TMEM132D transmembrane protein 132D 0.681983
ASPA aspartoacylase 0.681983
GLIS3 GLIS family zinc finger 3 0.681983
IQCJ IQ motif containing J 0.681983
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 0.681983
LUZP2 leucine zipper protein 2 0.681983
LOC728755 uncharacterized LOC728755 0.681983
ASTN2 astrotactin 2 0.681983
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1 0.681983
LAMA2 laminin, alpha 2 0.681983
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 0.681983
NTM neurotrimin 0.681983
SAMD3 sterile alpha motif domain containing 3 0.668836
CFAP61 cilia and flagella associated protein 61 0.668836
FRMD6 FERM domain containing 6 0.668836
SGK1 serum/glucocorticoid regulated kinase 1 0.668836
FAM111B family with sequence similarity 111, member B 0.668836
LINC00578 long intergenic non-protein coding RNA 578 0.668836
KIF16B kinesin family member 16B 0.668836
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.668836
RELN reelin 0.668836
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 0.668836
SLC9A9 solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9 0.668836
TMEM165 transmembrane protein 165 0.668836
MACROD2 MACRO domain containing 2 0.668836
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.668836
KIAA1456 KIAA1456 0.668836
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 0.668836
NKAIN3 Na+/K+ transporting ATPase interacting 3 0.668836
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.668836
CLOCK clock circadian regulator 0.668836
C6ORF7 chromosome 6 open reading frame 7 0.668836
LYN LYN proto-oncogene, Src family tyrosine kinase 0.668836
SCUBE1 signal peptide, CUB domain, EGF-like 1 0.668836
CNTN5 contactin 5 0.668836
ARHGAP15 Rho GTPase activating protein 15 0.668836
TOX thymocyte selection-associated high mobility group box 0.668836
SEMA3E sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E 0.668836
CCDC174 coiled-coil domain containing 174 0.668836
PARD3B par-3 family cell polarity regulator beta 0.668836
PELP1 proline, glutamate and leucine rich protein 1 0.668836
FAM189A1 family with sequence similarity 189, member A1 0.668836
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.668836
SPTBN1 spectrin, beta, non-erythrocytic 1 0.668836
LRP5L low density lipoprotein receptor-related protein 5-like 0.668836
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 0.668836
CSPP1 centrosome and spindle pole associated protein 1 0.668836
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein) 0.668836
FGF6 fibroblast growth factor 6 0.668836
CTIF CBP80/20-dependent translation initiation factor 0.668836
CD38 CD38 molecule 0.668836
SLIT1 slit homolog 1 (Drosophila) 0.668836
MAN2B2 mannosidase, alpha, class 2B, member 2 0.668836
C4ORF22 chromosome 4 open reading frame 22 0.668836
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.668836
PADI3 peptidyl arginine deiminase, type III 0.668836
NUP160 nucleoporin 160kDa 0.668836
CLIC5 chloride intracellular channel 5 0.668836
SNAP25 synaptosomal-associated protein, 25kDa 0.668836
PDZRN3 PDZ domain containing ring finger 3 0.668836
MINOS1-NBL1 MINOS1-NBL1 readthrough 0.668836
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 0.668836
OSBPL1A oxysterol binding protein-like 1A 0.668836
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila) 0.668836
SCN3A sodium channel, voltage gated, type III alpha subunit 0.668836
NXPH1 neurexophilin 1 0.668836
DCAF4 DDB1 and CUL4 associated factor 4 0.668836
ATXN1 ataxin 1 0.668836
IRAK3 interleukin-1 receptor-associated kinase 3 0.668836
THADA thyroid adenoma associated 0.668836
FAM163A family with sequence similarity 163, member A 0.668836
PDCL2 phosducin-like 2 0.625701
CHD2 chromodomain helicase DNA binding protein 2 0.621951
APAF1 apoptotic peptidase activating factor 1 0.615118
IKBIP IKBKB interacting protein 0.615118
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 0.605359
ZFYVE1 zinc finger, FYVE domain containing 1 0.60243
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 0.59964
TCF3 transcription factor 3 0.594024
CPM carboxypeptidase M 0.583982
CACHD1 cache domain containing 1 0.583982
NBEA neurobeachin 0.559045
RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 0.552035