diabetic neuropathy Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
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Genes

239 genes co-occuring with the disease diabetic neuropathy in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) 2.7045
NGF nerve growth factor (beta polypeptide) 1.92482
INS insulin 1.87285
NTF3 neurotrophin 3 1.43113
DNAH8 dynein, axonemal, heavy chain 8 1.39477
TAC1 tachykinin, precursor 1 1.3904
MARCH7 membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase 1.28959
CST7 cystatin F (leukocystatin) 1.18281
PARP1 poly (ADP-ribose) polymerase 1 1.16521
TRPV1 transient receptor potential cation channel, subfamily V, member 1 1.13205
CALCA calcitonin-related polypeptide alpha 1.11435
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit 1.08957
PPY pancreatic polypeptide 1.07572
SORD sorbitol dehydrogenase 1.0732
TRPA1 transient receptor potential cation channel, subfamily A, member 1 0.993596
PNPLA7 patatin-like phospholipase domain containing 7 0.975062
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.954108
STAP2 signal transducing adaptor family member 2 0.928759
NPS neuropeptide S 0.919261
IGF1 insulin-like growth factor 1 (somatomedin C) 0.917611
HBA1 hemoglobin, alpha 1 0.892538
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4 0.879014
HBA2 hemoglobin, alpha 2 0.869187
ALB albumin 0.854449
SCN8A sodium channel, voltage gated, type VIII alpha subunit 0.848716
SCN3A sodium channel, voltage gated, type III alpha subunit 0.834788
CNTF ciliary neurotrophic factor 0.819206
NTF4 neurotrophin 4 0.805667
SOD2 superoxide dismutase 2, mitochondrial 0.789672
GLO1 glyoxalase I 0.789262
PNPLA1 patatin-like phospholipase domain containing 1 0.781069
TKT transketolase 0.758601
INSR insulin receptor 0.749237
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.743954
GBP4 guanylate binding protein 4 0.733406
BOK BCL2-related ovarian killer 0.729357
TNNC2 troponin C type 2 (fast) 0.725311
GAN gigaxonin 0.722077
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 0.722077
GAP43 growth associated protein 43 0.721673
BDKRB1 bradykinin receptor B1 0.720058
SYNE2 spectrin repeat containing, nuclear envelope 2 0.718846
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 0.680297
PMP22 peripheral myelin protein 22 0.674315
NGFR nerve growth factor receptor 0.66596
BDNF brain-derived neurotrophic factor 0.660404
GDNF glial cell derived neurotrophic factor 0.659215
CAT catalase 0.65763
ATP11A ATPase, class VI, type 11A 0.645375
MAP3K6 mitogen-activated protein kinase kinase kinase 6 0.635921
ACE angiotensin I converting enzyme 0.618268
GCG glucagon 0.617877
LEP leptin 0.589779
MPZ myelin protein zero 0.580439
GBP5 guanylate binding protein 5 0.575383
CAMK2G calcium/calmodulin-dependent protein kinase II gamma 0.573828
HCN3 hyperpolarization activated cyclic nucleotide gated potassium channel 3 0.567997
TRPV3 transient receptor potential cation channel, subfamily V, member 3 0.56722
ZFR zinc finger RNA binding protein 0.566443
LEPR leptin receptor 0.563335
ANGPT1 angiopoietin 1 0.541217
SCN11A sodium channel, voltage gated, type XI alpha subunit 0.536957
DNM1L dynamin 1-like 0.530768
GRM1 glutamate receptor, metabotropic 1 0.526132
GALR1 galanin receptor 1 0.523816
AGER advanced glycosylation end product-specific receptor 0.521117
GALR2 galanin receptor 2 0.521117
ZNF521 zinc finger protein 521 0.510728
PPARG peroxisome proliferator-activated receptor gamma 0.501144
SCN10A sodium channel, voltage gated, type X alpha subunit 0.498085
CNR1 cannabinoid receptor 1 (brain) 0.496557
MLNR motilin receptor 0.490454
ATF3 activating transcription factor 3 0.488169
CLDN5 claudin 5 0.487788
NEFM neurofilament, medium polypeptide 0.482084
PIP5KL1 phosphatidylinositol-4-phosphate 5-kinase-like 1 0.474498
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2 0.474119
BAX BCL2-associated X protein 0.461639
ANK1 ankyrin 1, erythrocytic 0.457487
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma 0.456732
PTPN5 protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched) 0.453716
OPRM1 opioid receptor, mu 1 0.452585
MIOX myo-inositol oxygenase 0.451454
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 0.446558
ISYNA1 inositol-3-phosphate synthase 1 0.442418
NPY neuropeptide Y 0.44129
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha 0.43941
PNOC prepronociceptin 0.430768
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 0.430768
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.424389
TXNIP thioredoxin interacting protein 0.424389
PDPN podoplanin 0.423265
SKAP2 src kinase associated phosphoprotein 2 0.416896
FKBP4 FK506 binding protein 4, 59kDa 0.413901
PDCD2 programmed cell death 2 0.411283
SIRT1 sirtuin 1 0.403811
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 0.403438
CCT2 chaperonin containing TCP1, subunit 2 (beta) 0.401199
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) 0.399707
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.396725
KCNC4 potassium channel, voltage gated Shaw related subfamily C, member 4 0.395608
MYL1 myosin, light chain 1, alkali; skeletal, fast 0.388166
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.386679
AIF1 allograft inflammatory factor 1 0.385193
ETFB electron-transfer-flavoprotein, beta polypeptide 0.377402
VEGFA vascular endothelial growth factor A 0.374809
ARL2 ADP-ribosylation factor-like 2 0.371847
MYLPF myosin light chain, phosphorylatable, fast skeletal muscle 0.36741
CARD16 caspase recruitment domain family, member 16 0.361133
TNS2 tensin 2 0.355972
GAL galanin/GMAP prepropeptide 0.355972
ELAVL3 ELAV like neuron-specific RNA binding protein 3 0.354499
HMOX1 heme oxygenase 1 0.354131
SP9 Sp9 transcription factor 0.353763
AAAS achalasia, adrenocortical insufficiency, alacrimia 0.352291
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 0.351187
APOE apolipoprotein E 0.349349
UNC13A unc-13 homolog A (C. elegans) 0.347879
NOS3 nitric oxide synthase 3 (endothelial cell) 0.346777
GPX1 glutathione peroxidase 1 0.344941
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 0.344574
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5 0.343473
KCNQ2 potassium channel, voltage gated KQT-like subfamily Q, member 2 0.331756
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.330295
LIAS lipoic acid synthetase 0.328469
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 0.328105
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 0.325552
P2RY1 purinergic receptor P2Y, G-protein coupled, 1 0.323002
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 0.318272
ACHE acetylcholinesterase (Yt blood group) 0.315003
DENR density-regulated protein 0.313552
TNF tumor necrosis factor 0.313552
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta 0.311014
MAP6D1 MAP6 domain containing 1 0.308842
TRPM8 transient receptor potential cation channel, subfamily M, member 8 0.307757
NRN1 neuritin 1 0.301976
FADS2 fatty acid desaturase 2 0.291898
CNTNAP1 contactin associated protein 1 0.285802
SLC18A3 solute carrier family 18 (vesicular acetylcholine transporter), member 3 0.283297
FCF1 FCF1 rRNA-processing protein 0.279367
PDE5A phosphodiesterase 5A, cGMP-specific 0.270464
PEPD peptidase D 0.267977
IRS1 insulin receptor substrate 1 0.26266
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.260184
SYNM synemin, intermediate filament protein 0.25877
GRM2 glutamate receptor, metabotropic 2 0.258417
CLMP CXADR-like membrane protein 0.255594
ANO7P1 anoctamin 7 pseudogene 1 0.255241
DIAPH1 diaphanous-related formin 1 0.248554
FKBP1A FK506 binding protein 1A, 12kDa 0.24715
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 0.246098
ART3 ADP-ribosyltransferase 3 0.240497
HAGH hydroxyacylglutathione hydrolase 0.231102
PTOV1 prostate tumor overexpressed 1 0.22937
EPHX2 epoxide hydrolase 2, cytoplasmic 0.228333
SOD3 superoxide dismutase 3, extracellular 0.228333
CYP2D7 cytochrome P450, family 2, subfamily D, polypeptide 7 (gene/pseudogene) 0.226952
DBT dihydrolipoamide branched chain transacylase E2 0.224884
JUN jun proto-oncogene 0.221793
IRS2 insulin receptor substrate 2 0.221793
VWF von Willebrand factor 0.220766
TTR transthyretin 0.21974
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 0.218034
KNG1 kininogen 1 0.215653
ADRA2B adrenoceptor alpha 2B 0.211934
PRSS21 protease, serine, 21 (testisin) 0.211597
OLIG1 oligodendrocyte transcription factor 1 0.210253
SST somatostatin 0.209918
TMEM245 transmembrane protein 245 0.209248
AKR1A1 aldo-keto reductase family 1, member A1 (aldehyde reductase) 0.205585
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 0.202618
CLEC11A C-type lectin domain family 11, member A 0.201962
MAPK8 mitogen-activated protein kinase 8 0.198064
MN1 meningioma (disrupted in balanced translocation) 1 0.194548
TFAM transcription factor A, mitochondrial 0.1936
SP6 Sp6 transcription factor 0.193285
ADORA2A adenosine A2a receptor 0.192344
GCM2 glial cells missing homolog 2 (Drosophila) 0.186811
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1 0.18591
SEPT3 septin 3 0.184424
SPAG7 sperm associated antigen 7 0.184128
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3 0.183541
CRP C-reactive protein, pentraxin-related 0.180937
NEFH neurofilament, heavy polypeptide 0.180937
EPOR erythropoietin receptor 0.180652
LAD1 ladinin 1 0.176757
FOS FBJ murine osteosarcoma viral oncogene homolog 0.176215
GPX5 glutathione peroxidase 5 0.175411
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 0.175146
GPX4 glutathione peroxidase 4 0.173314
PTN pleiotrophin 0.172799
PDYN prodynorphin 0.172291
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2 0.172038
MGLL monoglyceride lipase 0.169091
APOB apolipoprotein B 0.168148
GHRL ghrelin/obestatin prepropeptide 0.167452
ACO2 aconitase 2, mitochondrial 0.162505
NOS2 nitric oxide synthase 2, inducible 0.161139
SNORA29 small nucleolar RNA, H/ACA box 29 0.159838
EDN1 endothelin 1 0.158434
MLN motilin 0.144338
PALLD palladin, cytoskeletal associated protein 0.144162
ZDHHC23 zinc finger, DHHC-type containing 23 0.144154
BPGM 2,3-bisphosphoglycerate mutase 0.14406
PGAM2 phosphoglycerate mutase 2 (muscle) 0.14404
RIPK4 receptor-interacting serine-threonine kinase 4 0.143642
MAGEC1 melanoma antigen family C1 0.143621
PGAM1 phosphoglycerate mutase 1 (brain) 0.143554
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 0.143507
NAGA N-acetylgalactosaminidase, alpha- 0.143413
WDR20 WD repeat domain 20 0.143189
CCL27 chemokine (C-C motif) ligand 27 0.143147
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.143065
PTPRN protein tyrosine phosphatase, receptor type, N 0.143056
TRAF3 TNF receptor-associated factor 3 0.14203
FBXO17 F-box protein 17 0.141821
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 0.141194
HMOX2 heme oxygenase 2 0.141164
CCL7 chemokine (C-C motif) ligand 7 0.140944
CPN1 carboxypeptidase N, polypeptide 1 0.140838
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3 0.140721
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 0.140434
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1 0.140389
SPTA1 spectrin, alpha, erythrocytic 1 0.140389
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.139994
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1 0.139524
C10ORF2 chromosome 10 open reading frame 2 0.139057
WDFY2 WD repeat and FYVE domain containing 2 0.138602
SLC35A2 solute carrier family 35 (UDP-galactose transporter), member A2 0.13845
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase 0.137933
POLG polymerase (DNA directed), gamma 0.137636
MIR146A microRNA 146a 0.137356
TYRO3 TYRO3 protein tyrosine kinase 0.136081
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) 0.135901
SREBF1 sterol regulatory element binding transcription factor 1 0.135773
TH tyrosine hydroxylase 0.135717
ETV3 ets variant 3 0.134916
VCL vinculin 0.134812
TRO trophinin 0.13475