desmosome Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A cell-cell junction in which: on the cytoplasmic surface of each interacting plasma membrane is a dense plaque composed of a mixture of intracellular anchor proteins; a bundle of keratin intermediate filaments is attached to the surface of each plaque; transmembrane adhesion proteins of the cadherin family bind to the plaques and interact through their extracellular domains to hold the adjacent membranes together by a Ca2+-dependent mechanism. (Gene Ontology, GO_0030057)
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Genes

224 proteins co-occuring with the desmosome cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
DSP desmoplakin 3.40607
DSG1 desmoglein 1 3.34841
DSG3 desmoglein 3 3.13674
JUP junction plakoglobin 3.09915
DSG2 desmoglein 2 2.85658
DSC2 desmocollin 2 2.76516
PKP2 plakophilin 2 2.67442
DSC3 desmocollin 3 2.55303
PKP1 plakophilin 1 2.41999
DSC1 desmocollin 1 2.06413
PKP3 plakophilin 3 1.82795
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 1.74829
CDSN corneodesmosin 1.72432
DSG4 desmoglein 4 1.68543
PERP PERP, TP53 apoptosis effector 1.53387
PPL periplakin 1.39127
PKP4 plakophilin 4 1.38405
TMEM43 transmembrane protein 43 1.28356
IVL involucrin 1.2825
TJP1 tight junction protein 1 1.27399
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 1.2539
GJA1 gap junction protein, alpha 1, 43kDa 1.2179
EVPL envoplakin 1.17978
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.16645
OCLN occludin 1.11378
FLG filaggrin 1.10358
KLK5 kallikrein-related peptidase 5 1.05337
LOR loricrin 1.05136
PNN pinin, desmosome associated protein 1.02231
KAZN kazrin, periplakin interacting protein 0.992204
VCL vinculin 0.980016
CTNND1 catenin (cadherin-associated protein), delta 1 0.97178
ENO2 enolase 2 (gamma, neuronal) 0.966956
KRT18 keratin 18, type I 0.96503
KRT14 keratin 14, type I 0.962627
KLK7 kallikrein-related peptidase 7 0.959268
COL17A1 collagen, type XVII, alpha 1 0.930774
KRT10 keratin 10, type I 0.930304
KRT1 keratin 1, type II 0.929833
FBXO7 F-box protein 7 0.906926
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome 0.887936
CTNNA3 catenin (cadherin-associated protein), alpha 3 0.886551
KRT13 keratin 13, type I 0.862149
LY6D lymphocyte antigen 6 complex, locus D 0.851124
SPINK5 serine peptidase inhibitor, Kazal type 5 0.831843
CLDN7 claudin 7 0.829548
KRT7 keratin 7, type II 0.792854
CLDN1 claudin 1 0.781412
CD79A CD79a molecule, immunoglobulin-associated alpha 0.770451
KRT3 keratin 3, type II 0.767715
SYMPK symplekin 0.765438
KRT8 keratin 8, type II 0.759524
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 0.738713
AFP alpha-fetoprotein 0.705273
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.689451
KRT12 keratin 12, type I 0.677238
MBTPS2 membrane-bound transcription factor peptidase, site 2 0.662503
KRT4 keratin 4, type II 0.66164
CTNND2 catenin (cadherin-associated protein), delta 2 0.648721
KRT5 keratin 5, type II 0.646145
FN1 fibronectin 1 0.645287
ALPPL2 alkaline phosphatase, placental-like 2 0.629892
ALPP alkaline phosphatase, placental 0.629892
ALPL alkaline phosphatase, liver/bone/kidney 0.629465
ANXA9 annexin A9 0.61883
KRT20 keratin 20, type I 0.612471
TGFB3 transforming growth factor, beta 3 0.597276
F8 coagulation factor VIII, procoagulant component 0.596014
CLDN4 claudin 4 0.595173
CD68 CD68 molecule 0.588456
GFAP glial fibrillary acidic protein 0.584268
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.572162
CDH5 cadherin 5, type 2 (vascular endothelium) 0.560943
CGN cingulin 0.555145
KRT81 keratin 81, type II 0.547297
SRRM1 serine/arginine repetitive matrix 1 0.537827
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.536183
KLK14 kallikrein-related peptidase 14 0.535772
KRTAP3-2 keratin associated protein 3-2 0.535772
MARCH7 membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase 0.528388
SYP synaptophysin 0.51164
CSRNP3 cysteine-serine-rich nuclear protein 3 0.50757
KRT73 keratin 73, type II 0.50635
KLK6 kallikrein-related peptidase 6 0.501476
KRT16 keratin 16, type I 0.500664
KRT86 keratin 86, type II 0.491348
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.489327
PKD1 polycystic kidney disease 1 (autosomal dominant) 0.486904
PCNA proliferating cell nuclear antigen 0.482467
KRT71 keratin 71, type II 0.475625
CD34 CD34 molecule 0.474018
TF transferrin 0.473215
COL7A1 collagen, type VII, alpha 1 0.471609
PCDH20 protocadherin 20 0.470406
INS insulin 0.470406
AHNAK AHNAK nucleoprotein 0.464397
ACPP acid phosphatase, prostate 0.463198
TP53 tumor protein p53 0.461998
PTGER4 prostaglandin E receptor 4 (subtype EP4) 0.459203
PCDH9 protocadherin 9 0.45641
CRNN cornulin 0.45641
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.450438
ANKK1 ankyrin repeat and kinase domain containing 1 0.443292
VSX1 visual system homeobox 1 0.441312
THBD thrombomodulin 0.43617
EGFR epidermal growth factor receptor 0.43538
BSPRY B-box and SPRY domain containing 0.432618
A2ML1 alpha-2-macroglobulin-like 1 0.432224
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 0.427891
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 0.420036
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C) 0.41612
CALCA calcitonin-related polypeptide alpha 0.413382
CALB2 calbindin 2 0.413382
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.397811
STRN striatin, calmodulin binding protein 0.392001
HAVCR2 hepatitis A virus cellular receptor 2 0.389296
JAM3 junctional adhesion molecule 3 0.385436
FTL ferritin, light polypeptide 0.382739
FTH1 ferritin, heavy polypeptide 1 0.380814
CDX1 caudal type homeobox 1 0.380429
CDH20 cadherin 20, type 2 0.37966
OVOL1 ovo-like zinc finger 1 0.37966
AK7 adenylate kinase 7 0.370833
GRHL1 grainyhead-like 1 (Drosophila) 0.369301
HYAL3 hyaluronoglucosaminidase 3 0.362804
ALB albumin 0.36204
TG thyroglobulin 0.357467
CDH18 cadherin 18, type 2 0.357086
KRT9 keratin 9, type I 0.354802
TP63 tumor protein p63 0.353662
LEF1 lymphoid enhancer-binding factor 1 0.340773
LLGL2 lethal giant larvae homolog 2 (Drosophila) 0.338506
KRT19 keratin 19, type I 0.337373
DSPP dentin sialophosphoprotein 0.332472
KANK2 KN motif and ankyrin repeat domains 2 0.326453
EPN3 epsin 3 0.325327
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B) 0.319702
ITGA6 integrin, alpha 6 0.318579
CD44 CD44 molecule (Indian blood group) 0.314091
TCHH trichohyalin 0.305515
EIF4A1 eukaryotic translation initiation factor 4A1 0.305143
MEOX1 mesenchyme homeobox 1 0.304027
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 0.302168
DES desmin 0.301797
UPK3A uroplakin 3A 0.296972
PCDH12 protocadherin 12 0.291417
CSTA cystatin A (stefin A) 0.291047
CDH10 cadherin 10, type 2 (T2-cadherin) 0.286245
CSH2 chorionic somatomammotropin hormone 2 0.284769
PCDH18 protocadherin 18 0.284401
KLK13 kallikrein-related peptidase 13 0.284401
TJP2 tight junction protein 2 0.283295
CDHR1 cadherin-related family member 1 0.281453
CLEC2A C-type lectin domain family 2, member A 0.280716
ADAM22 ADAM metallopeptidase domain 22 0.278877
KRT80 keratin 80, type II 0.277038
GRHL2 grainyhead-like 2 (Drosophila) 0.276304
GJB1 gap junction protein, beta 1, 32kDa 0.274835
STARD7 StAR-related lipid transfer (START) domain containing 7 0.274468
KRT74 keratin 74, type II 0.269335
COL8A2 collagen, type VIII, alpha 2 0.268237
CLK3 CDC-like kinase 3 0.264946
PCDH7 protocadherin 7 0.260931
FXR1 fragile X mental retardation, autosomal homolog 1 0.257652
CD99 CD99 molecule 0.252564
PVRL3 poliovirus receptor-related 3 0.248578
PLG plasminogen 0.247492
EPCAM epithelial cell adhesion molecule 0.246769
CDX2 caudal type homeobox 2 0.246046
ITGB4 integrin, beta 4 0.240996
EDAR ectodysplasin A receptor 0.240636
SLC15A1 solute carrier family 15 (oligopeptide transporter), member 1 0.240636
CLDN3 claudin 3 0.235966
THY1 Thy-1 cell surface antigen 0.235607
DNAH8 dynein, axonemal, heavy chain 8 0.235607
CARD6 caspase recruitment domain family, member 6 0.229532
CHGA chromogranin A 0.224913
LYZ lysozyme 0.222083
TMPO thymopoietin 0.222083
POMC proopiomelanocortin 0.215761
S100A14 S100 calcium binding protein A14 0.211587
SHOC2 soc-2 suppressor of clear homolog (C. elegans) 0.210203
FOXN1 forkhead box N1 0.208481
RICTOR RPTOR independent companion of MTOR, complex 2 0.20574
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) 0.205399
DST dystonin 0.204718
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 0.204718
LGALS3 lectin, galactoside-binding, soluble, 3 0.203361
GRHL3 grainyhead-like 3 (Drosophila) 0.197662
RNPS1 RNA binding protein S1, serine-rich domain 0.196339
CLMP CXADR-like membrane protein 0.194371
FRY furry homolog (Drosophila) 0.191456
MUC5B mucin 5B, oligomeric mucus/gel-forming 0.191135
HNF4A hepatocyte nuclear factor 4, alpha 0.190814
MARVELD3 MARVEL domain containing 3 0.183935
GJB2 gap junction protein, beta 2, 26kDa 0.183935
ADAM17 ADAM metallopeptidase domain 17 0.181524
KITLG KIT ligand 0.18093
RND3 Rho family GTPase 3 0.179459
PCDH17 protocadherin 17 0.179459
GPD1L glycerol-3-phosphate dehydrogenase 1-like 0.179167
ARHGAP12 Rho GTPase activating protein 12 0.178011
PGR progesterone receptor 0.177724
TGM1 transglutaminase 1 0.177724
PCDH10 protocadherin 10 0.177439
AMELX amelogenin, X-linked 0.177154
SCN3A sodium channel, voltage gated, type III alpha subunit 0.174361
HPN hepsin 0.174361
PCDH1 protocadherin 1 0.173814
ICOS inducible T-cell co-stimulator 0.173543
YOD1 YOD1 deubiquitinase 0.173543
RYR2 ryanodine receptor 2 (cardiac) 0.172468
TEAD4 TEA domain family member 4 0.172468
AMELY amelogenin, Y-linked 0.172201
KLF4 Kruppel-like factor 4 (gut) 0.168847
ICAM1 intercellular adhesion molecule 1 0.167611
B3GAT1 beta-1,3-glucuronyltransferase 1 0.167366
LATS1 large tumor suppressor kinase 1 0.166884
HOXD3 homeobox D3 0.166643
NIPAL4 NIPA-like domain containing 4 0.160053
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 0.159074
PTPRC protein tyrosine phosphatase, receptor type, C 0.157578
MARVELD2 MARVEL domain containing 2 0.157397
AMICA1 adhesion molecule, interacts with CXADR antigen 1 0.157218