dendritic spine head Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description Distal part of the dendritic spine, that carries the post-synaptic density. (Gene Ontology, GO_0044327)
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Genes

331 proteins co-occuring with the dendritic spine head cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 2.35932
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 2.14569
SHANK3 SH3 and multiple ankyrin repeat domains 3 2.14059
GRIA1 glutamate receptor, ionotropic, AMPA 1 2.11512
HOMER1 homer scaffolding protein 1 2.00621
DLG3 discs, large homolog 3 (Drosophila) 1.95653
DLG1 discs, large homolog 1 (Drosophila) 1.90979
PSD pleckstrin and Sec7 domain containing 1.87727
TJP1 tight junction protein 1 1.85045
SHANK1 SH3 and multiple ankyrin repeat domains 1 1.76496
SHANK2 SH3 and multiple ankyrin repeat domains 2 1.75211
GUK1 guanylate kinase 1 1.66901
DLG4 discs, large homolog 4 (Drosophila) 1.65152
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 1.51412
CAMK2G calcium/calmodulin-dependent protein kinase II gamma 1.47061
LRRC7 leucine rich repeat containing 7 1.3752
BDNF brain-derived neurotrophic factor 1.34174
GPHN gephyrin 1.32438
CALM3 calmodulin 3 (phosphorylase kinase, delta) 1.27611
CALM1 calmodulin 1 (phosphorylase kinase, delta) 1.27558
CALM2 calmodulin 2 (phosphorylase kinase, delta) 1.27558
SYP synaptophysin 1.26974
GRIP1 glutamate receptor interacting protein 1 1.23296
GRIA2 glutamate receptor, ionotropic, AMPA 2 1.21946
GRM5 glutamate receptor, metabotropic 5 1.1952
PICK1 protein interacting with PRKCA 1 1.1952
DLGAP2 discs, large (Drosophila) homolog-associated protein 2 1.18851
HOMER2 homer scaffolding protein 2 1.17004
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C 1.16133
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 1.12858
PPP1R9B protein phosphatase 1, regulatory subunit 9B 1.11072
NLGN1 neuroligin 1 1.10205
GRIA4 glutamate receptor, ionotropic, AMPA 4 1.07866
GRM1 glutamate receptor, metabotropic 1 1.07714
PISD phosphatidylserine decarboxylase 1.04783
SRC SRC proto-oncogene, non-receptor tyrosine kinase 1.04683
CABP1 calcium binding protein 1 1.02679
GRIA3 glutamate receptor, ionotropic, AMPA 3 1.02032
CRIPT cysteine-rich PDZ-binding protein 1.01337
RAP1GAP RAP1 GTPase activating protein 1.00596
BAIAP2 BAI1-associated protein 2 0.987806
RBM10 RNA binding motif protein 10 0.946857
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 0.941636
DBN1 drebrin 1 0.929833
ARC activity-regulated cytoskeleton-associated protein 0.926074
SYN1 synapsin I 0.924666
BSN bassoon presynaptic cytomatrix protein 0.919046
FYN FYN proto-oncogene, Src family tyrosine kinase 0.904602
CNKSR2 connector enhancer of kinase suppressor of Ras 2 0.902281
MARCH7 membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase 0.876409
NLGN2 neuroligin 2 0.86077
CTNND2 catenin (cadherin-associated protein), delta 2 0.859392
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.841941
IQSEC2 IQ motif and Sec7 domain 2 0.830466
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.802479
MPDZ multiple PDZ domain protein 0.79927
GRIK1 glutamate receptor, ionotropic, kainate 1 0.796979
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 0.793313
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7 0.747285
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D 0.739163
SDCBP2 syndecan binding protein (syntenin) 2 0.734666
NETO1 neuropilin (NRP) and tolloid (TLL)-like 1 0.729732
KCNA4 potassium channel, voltage gated shaker related subfamily A, member 4 0.725258
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 0.721688
BEGAIN brain-enriched guanylate kinase-associated 0.715014
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 0.712351
SHARPIN SHANK-associated RH domain interactor 0.711465
DLGAP3 discs, large (Drosophila) homolog-associated protein 3 0.711465
DNM3 dynamin 3 0.707924
PRR7 proline rich 7 (synaptic) 0.706598
PDZK1 PDZ domain containing 1 0.703949
PDLIM5 PDZ and LIM domain 5 0.702185
PVALB parvalbumin 0.701744
RGS7BP regulator of G-protein signaling 7 binding protein 0.699103
MAP2 microtubule-associated protein 2 0.692078
ERBB4 erb-b2 receptor tyrosine kinase 4 0.686827
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 0.681591
CAMK2N2 calcium/calmodulin-dependent protein kinase II inhibitor 2 0.675065
CREB1 cAMP responsive element binding protein 1 0.654741
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 0.641429
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.634159
ACTN2 actinin, alpha 2 0.626057
CALB1 calbindin 1, 28kDa 0.623079
NEXN nexilin (F actin binding protein) 0.617557
HOMER3 homer scaffolding protein 3 0.615013
MAP1A microtubule-associated protein 1A 0.608241
RELN reelin 0.607395
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 0.60655
CTTN cortactin 0.601066
BAIAP2L1 BAI1-associated protein 2-like 1 0.599381
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1 0.592232
FMR1 fragile X mental retardation 1 0.580086
LIN7A lin-7 homolog A (C. elegans) 0.571745
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 0.568416
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.565508
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.565092
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3 0.563432
ISL1 ISL LIM homeobox 1 0.562602
ANK1 ankyrin 1, erythrocytic 0.562187
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa 0.561772
CTBP2 C-terminal binding protein 2 0.556387
ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9 0.555973
DISC1 disrupted in schizophrenia 1 0.54936
GDA guanine deaminase 0.548535
INA internexin neuronal intermediate filament protein, alpha 0.545648
TARP TCR gamma alternate reading frame protein 0.543176
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 0.537416
SCRIB scribbled planar cell polarity protein 0.527979
CDK5 cyclin-dependent kinase 5 0.526341
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 0.525931
RNASE13 ribonuclease, RNase A family, 13 (non-active) 0.520615
SYNGAP1 synaptic Ras GTPase activating protein 1 0.518165
SDCBP syndecan binding protein (syntenin) 0.514085
LRRTM1 leucine rich repeat transmembrane neuronal 1 0.512862
GJD2 gap junction protein, delta 2, 36kDa 0.510826
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.505131
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2 0.503506
ZDHHC8 zinc finger, DHHC-type containing 8 0.498636
PRICKLE2 prickle homolog 2 (Drosophila) 0.498231
PTCHD1 patched domain containing 1 0.496205
RAP1GAP2 RAP1 GTPase activating protein 2 0.490539
PPAPDC2 phosphatidic acid phosphatase type 2 domain containing 2 0.490135
EPHB2 EPH receptor B2 0.488519
LRRC4 leucine rich repeat containing 4 0.485693
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B 0.484886
FBXO33 F-box protein 33 0.484079
ADGRL3 adhesion G protein-coupled receptor L3 0.482064
LZTS2 leucine zipper, putative tumor suppressor 2 0.481661
GAP43 growth associated protein 43 0.480453
SEZ6 seizure related 6 homolog (mouse) 0.47844
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.471208
ARF6 ADP-ribosylation factor 6 0.465598
ZDHHC2 zinc finger, DHHC-type containing 2 0.465198
PLEK pleckstrin 0.462798
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) 0.4608
ADGRL2 adhesion G protein-coupled receptor L2 0.459203
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.458803
NCR3 natural cytotoxicity triggering receptor 3 0.457606
DMD dystrophin 0.456809
EPHB3 EPH receptor B3 0.45641
TH tyrosine hydroxylase 0.447259
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 0.444878
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta 0.444085
ABI2 abl-interactor 2 0.444085
GOPC golgi-associated PDZ and coiled-coil motif containing 0.436565
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2 0.433407
SNTA1 syntrophin, alpha 1 0.431829
BTBD3 BTB (POZ) domain containing 3 0.424745
GRIK2 glutamate receptor, ionotropic, kainate 2 0.42396
CBLN1 cerebellin 1 precursor 0.42396
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.421604
KALRN kalirin, RhoGEF kinase 0.42082
NRXN1 neurexin 1 0.420428
ZMYND19 zinc finger, MYND-type containing 19 0.416902
LRFN4 leucine rich repeat and fibronectin type III domain containing 4 0.415728
GNB5 guanine nucleotide binding protein (G protein), beta 5 0.415337
GRM3 glutamate receptor, metabotropic 3 0.414164
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 0.414164
PSD2 pleckstrin and Sec7 domain containing 2 0.413382
PDZD3 PDZ domain containing 3 0.410259
VEZT vezatin, adherens junctions transmembrane protein 0.409089
NLGN3 neuroligin 3 0.400527
AKAP5 A kinase (PRKA) anchor protein 5 0.398975
NSF N-ethylmaleimide-sensitive factor 0.397035
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.394323
MECP2 methyl CpG binding protein 2 0.389296
OPN1MW opsin 1 (cone pigments), medium-wave-sensitive 0.387365
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.375434
SERF1B small EDRK-rich factor 1B (centromeric) 0.373899
SERF1A small EDRK-rich factor 1A (telomeric) 0.373899
APLP1 amyloid beta (A4) precursor-like protein 1 0.371599
ARHGAP32 Rho GTPase activating protein 32 0.37045
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3 0.369684
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2 0.369301
ASIC3 acid sensing (proton gated) ion channel 3 0.368536
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3) 0.368153
IQSEC3 IQ motif and Sec7 domain 3 0.367771
PPP1R9A protein phosphatase 1, regulatory subunit 9A 0.367771
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2 0.365477
TBKBP1 TBK1 binding protein 1 0.363567
KLHL17 kelch-like family member 17 0.362422
OPN1LW opsin 1 (cone pigments), long-wave-sensitive 0.36204
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 0.361659
KARS lysyl-tRNA synthetase 0.356324
TRIM11 tripartite motif containing 11 0.349484
MORN4 MORN repeat containing 4 0.348725
GRID2 glutamate receptor, ionotropic, delta 2 0.347967
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 0.345314
CALB2 calbindin 2 0.341907
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.341907
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa 0.335487
SHISA9 shisa family member 9 0.33511
ITPKB inositol-trisphosphate 3-kinase B 0.333979
GRM2 glutamate receptor, metabotropic 2 0.333225
EZR ezrin 0.332095
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3 0.331342
LRFN1 leucine rich repeat and fibronectin type III domain containing 1 0.330589
PTPRD protein tyrosine phosphatase, receptor type, D 0.329084
SYNPO synaptopodin 0.326829
CDC42 cell division cycle 42 0.325702
IL16 interleukin 16 0.324951
EPHA4 EPH receptor A4 0.323075
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 0.323075
NRG1 neuregulin 1 0.323075
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A 0.32195
CYP4F22 cytochrome P450, family 4, subfamily F, polypeptide 22 0.321575
DNM2 dynamin 2 0.320826
CADM1 cell adhesion molecule 1 0.320451
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.319702
LRFN3 leucine rich repeat and fibronectin type III domain containing 3 0.319328
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 0.317456
NGF nerve growth factor (beta polypeptide) 0.317082
PPM1F protein phosphatase, Mg2+/Mn2+ dependent, 1F 0.316708
ADAM22 ADAM metallopeptidase domain 22 0.313344
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 0.311478
PTK2B protein tyrosine kinase 2 beta 0.310358
LRFN2 leucine rich repeat and fibronectin type III domain containing 2 0.310358
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 0.30924
DTNB dystrobrevin, beta 0.307377
NRCAM neuronal cell adhesion molecule 0.30626
KIF26B kinesin family member 26B 0.304027
EPS8 epidermal growth factor receptor pathway substrate 8 0.301054
SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1 0.300311
SEMA4F sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F 0.29994
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 0.293637
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.291417
DRD2 dopamine receptor D2 0.291047
CACNG2 calcium channel, voltage-dependent, gamma subunit 2 0.290678
SRCIN1 SRC kinase signaling inhibitor 1 0.284769
TRIM3 tripartite motif containing 3 0.283663
PBK PDZ binding kinase 0.282558
CCDC88C coiled-coil domain containing 88C 0.280349
MPP5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5) 0.279612
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4 0.279612
DAGLA diacylglycerol lipase, alpha 0.277406
MYO5A myosin VA (heavy chain 12, myoxin) 0.274468
SORCS3 sortilin-related VPS10 domain containing receptor 3 0.273367
SLC16A4 solute carrier family 16, member 4 0.272633
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like 0.271167
CRMP1 collapsin response mediator protein 1 0.266774
STRN striatin, calmodulin binding protein 0.266408
CNIH2 cornichon family AMPA receptor auxiliary protein 2 0.258381
HTRA2 HtrA serine peptidase 2 0.256561
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.25438
ADGRL1 adhesion G protein-coupled receptor L1 0.254017
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 0.247492
NTNG1 netrin G1 0.247492
PHC3 polyhomeotic homolog 3 (Drosophila) 0.245685
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5 0.243879
LGI1 leucine-rich, glioma inactivated 1 0.242076
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 0.240996
GRIP2 glutamate receptor interacting protein 2 0.240996
RAB11FIP2 RAB11 family interacting protein 2 (class I) 0.240276
EPB41 erythrocyte membrane protein band 4.1 0.236683
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.234174
RGS9 regulator of G-protein signaling 9 0.233817
NIPSNAP1 nipsnap homolog 1 (C. elegans) 0.233101
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.232386
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.226686
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C 0.226686
NLGN4X neuroligin 4, X-linked 0.226331
DGKB diacylglycerol kinase, beta 90kDa 0.224204
SAMD4A sterile alpha motif domain containing 4A 0.222436
PCDH9 protocadherin 9 0.219617
NOS1 nitric oxide synthase 1 (neuronal) 0.219617
DRP2 dystrophin related protein 2 0.218563
DTNBP1 dystrobrevin binding protein 1 0.218563
PDLIM2 PDZ and LIM domain 2 (mystique) 0.218212
PPP2R4 protein phosphatase 2A activator, regulatory subunit 4 0.215412
KIF1B kinesin family member 1B 0.214714
INADL InaD-like (Drosophila) 0.214714
CPLX2 complexin 2 0.214017
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 0.211933
RIMS3 regulating synaptic membrane exocytosis 3 0.21124
APC adenomatous polyposis coli 0.210549
GRID2IP glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein 0.210203
MMP24 matrix metallopeptidase 24 (membrane-inserted) 0.209858
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase 0.208825
PLK2 polo-like kinase 2 0.208481
PPP1R12C protein phosphatase 1, regulatory subunit 12C 0.208137
GSK3B glycogen synthase kinase 3 beta 0.20574
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.205059
NGFR nerve growth factor receptor 0.205059
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4 0.205059
CPEB1 cytoplasmic polyadenylation element binding protein 1 0.204718
KLHL1 kelch-like family member 1 0.203699
FXYD6 FXYD domain containing ion transport regulator 6 0.203361
PKD1P6 polycystic kidney disease 1 (autosomal dominant) pseudogene 6 0.201672
MYH15 myosin, heavy chain 15 0.197662
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled 0.196669
CYLD cylindromatosis (turban tumor syndrome) 0.193394
UBE3A ubiquitin protein ligase E3A 0.193394
NOSIP nitric oxide synthase interacting protein 0.191777
KCNJ14 potassium channel, inwardly rectifying subfamily J, member 14 0.189857
CPLX1 complexin 1 0.188274
VASP vasodilator-stimulated phosphoprotein 0.18516
SYT1 synaptotagmin I 0.184241
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2 0.180634
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.180634
MAPT microtubule-associated protein tau 0.179752
AMPH amphiphysin 0.178588
LRRC4C leucine rich repeat containing 4C 0.178011
VANGL2 VANGL planar cell polarity protein 2 0.17687
HTT huntingtin 0.17687
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 0.176305
DYNLL2 dynein, light chain, LC8-type 2 0.173543
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta 0.173543
UTRN utrophin 0.171149
TLL1 tolloid-like 1 0.168847
INSR insulin receptor 0.168349
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6 0.168349
SNAP25 synaptosomal-associated protein, 25kDa 0.166884
RTN4 reticulon 4 0.165
TMBIM4 transmembrane BAX inhibitor motif containing 4 0.164315
CNR1 cannabinoid receptor 1 (brain) 0.164089
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.164089
APP amyloid beta (A4) precursor protein 0.16342
SST somatostatin 0.16298
AGRN agrin 0.161905
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2 0.161693
PDLIM4 PDZ and LIM domain 4 0.161068
ADAM10 ADAM metallopeptidase domain 10 0.160456
GIPC1 GIPC PDZ domain containing family, member 1 0.160456
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 0.160456
NDFIP1 Nedd4 family interacting protein 1 0.159856
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.159074
WDR92 WD repeat domain 92 0.158502
NTNG2 netrin G2 0.15776
TIAM2 T-cell lymphoma invasion and metastasis 2 0.157218
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E 0.156513
NTF4 neurotrophin 4 0.156513