dementia Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness. (Experimental Factor Ontology, EFO_0003862)
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Genes

198 genes co-occuring with the biological term dementia in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCD1 ATP-binding cassette, sub-family D (ALD), member 1
ACE angiotensin I converting enzyme
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ADIPOQ adiponectin, C1Q and collagen domain containing
ADORA2A adenosine A2a receptor
AGER advanced glycosylation end product-specific receptor
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALDH18A1 aldehyde dehydrogenase 18 family, member A1
ANGPT4 angiopoietin 4
APCS amyloid P component, serum
APOA1 apolipoprotein A-I
APOB apolipoprotein B
APOC1 apolipoprotein C-I
APOE apolipoprotein E
APP amyloid beta (A4) precursor protein
ARSA arylsulfatase A
ATP13A2 ATPase type 13A2
ATPAF2 ATP synthase mitochondrial F1 complex assembly factor 2
ATXN2 ataxin 2
AVP arginine vasopressin
BACE1 beta-site APP-cleaving enzyme 1
BAX BCL2-associated X protein
BCHE butyrylcholinesterase
BCL2 B-cell CLL/lymphoma 2
BDNF brain-derived neurotrophic factor
C10ORF2 chromosome 10 open reading frame 2
C5AR1 complement component 5a receptor 1
C9ORF72 chromosome 9 open reading frame 72
CALHM1 calcium homeostasis modulator 1
CARTPT CART prepropeptide
CDKN2A-AS1 CDKN2A antisense RNA 1 (head to head)
CETP cholesteryl ester transfer protein, plasma
CHAT choline O-acetyltransferase
CHCHD10 coiled-coil-helix-coiled-coil-helix domain containing 10
CHMP2B charged multivesicular body protein 2B
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal)
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CNSN Carnosinemia (carnosinase)
COMT catechol-O-methyltransferase
CRP C-reactive protein, pentraxin-related
CST3 cystatin C
CTSD cathepsin D
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
DAPK1 death-associated protein kinase 1
DMPK dystrophia myotonica-protein kinase
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DPYSL2 dihydropyrimidinase-like 2
DRD3 dopamine receptor D3
E2F1 E2F transcription factor 1
ECE1 endothelin converting enzyme 1
EFHD2 EF-hand domain family, member D2
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
ELAVL1 ELAV like RNA binding protein 1
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP3 fatty acid binding protein 3, muscle and heart
FAM134B family with sequence similarity 134, member B
FMR1 fragile X mental retardation 1
FUS FUS RNA binding protein
GAB2 GRB2-associated binding protein 2
GAN gigaxonin
GBA glucosidase, beta, acid
GHRL ghrelin/obestatin prepropeptide
GLS glutaminase
GLS2 glutaminase 2 (liver, mitochondrial)
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
GPX1 glutathione peroxidase 1
GRN granulin
GSTO1 glutathione S-transferase omega 1
HCRT hypocretin (orexin) neuropeptide precursor
HFE hemochromatosis
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1
HRH3 histamine receptor H3
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
ICAM1 intercellular adhesion molecule 1
IDE insulin-degrading enzyme
IGF1 insulin-like growth factor 1 (somatomedin C)
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL6 interleukin 6
ITM2B integral membrane protein 2B
JPH3 junctophilin 3
KLK10 kallikrein-related peptidase 10
KLK6 kallikrein-related peptidase 6
KLK7 kallikrein-related peptidase 7
LEP leptin
LMNA lamin A/C
LOC643387 TAR DNA binding protein pseudogene
LRRK2 leucine-rich repeat kinase 2
MAOA monoamine oxidase A
MAOB monoamine oxidase B
MAPT microtubule-associated protein tau
MBP myelin basic protein
MIR29B1 microRNA 29b-1
MIR29B2 microRNA 29b-2
MIR659 microRNA 659
MME membrane metallo-endopeptidase
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
MOBP myelin-associated oligodendrocyte basic protein
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NES nestin
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NPPB natriuretic peptide B
OPTN optineurin
OTUD4 OTU deubiquitinase 4
PARK2 parkin RBR E3 ubiquitin protein ligase
PENK proenkephalin
PER1 period circadian clock 1
PFN1 profilin 1
PHLDB2 pleckstrin homology-like domain, family B, member 2
PICALM phosphatidylinositol binding clathrin assembly protein
PINK1 PTEN induced putative kinase 1
PKNOX1 PBX/knotted 1 homeobox 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PLAUR plasminogen activator, urokinase receptor
PON1 paraoxonase 1
PON2 paraoxonase 2
PPARG peroxisome proliferator-activated receptor gamma
PRNP prion protein
PSEN1 presenilin 1
PSEN2 presenilin 2
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTH parathyroid hormone
QPCT glutaminyl-peptide cyclotransferase
RELN reelin
RNF216 ring finger protein 216
RPGRIP1L RPGRIP1-like
RPH3A rabphilin 3A
RUNX1 runt-related transcription factor 1
S100B S100 calcium binding protein B
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA13P serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 13, pseudogene
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SHBG sex hormone-binding globulin
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SNAP25 synaptosomal-associated protein, 25kDa
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNCAIP synuclein, alpha interacting protein
SNCB synuclein, beta
SNCG synuclein, gamma (breast cancer-specific protein 1)
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPAST spastin
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome)
SPON1 spondin 1, extracellular matrix protein
SPPL2B signal peptide peptidase like 2B
SQSTM1 sequestosome 1
SREBF1 sterol regulatory element binding transcription factor 1
SREBF2 sterol regulatory element binding transcription factor 2
STH saitohin
STX1A syntaxin 1A (brain)
SYK spleen tyrosine kinase
SYP synaptophysin
TAC1 tachykinin, precursor 1
TARDBP TAR DNA binding protein
TFAM transcription factor A, mitochondrial
TGFB1 transforming growth factor, beta 1
THBS1 thrombospondin 1
TIMP1 TIMP metallopeptidase inhibitor 1
TNF tumor necrosis factor
TNFRSF19 tumor necrosis factor receptor superfamily, member 19
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14
TOM1L2 target of myb1-like 2 (chicken)
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast)
TP53 tumor protein p53
TREM2 triggering receptor expressed on myeloid cells 2
TSC2 tuberous sclerosis 2
TSPO translocator protein (18kDa)
TTR transthyretin
TYROBP TYRO protein tyrosine kinase binding protein
UBQLN2 ubiquilin 2
UNC13A unc-13 homolog A (C. elegans)
VCP valosin containing protein
VEGFA vascular endothelial growth factor A
VSNL1 visinin-like 1
WWC1 WW and C2 domain containing 1
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase