dementia Gene Set

Dataset GAD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A cognitive disorder resulting from a loss of brain function affecting memory, thinking, language, judgement and behavior. (Human Disease Ontology, DOID_1307)
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Genes

61 genes associated with the disease dementia in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2
ACAT1 acetyl-CoA acetyltransferase 1
ACAT2 acetyl-CoA acetyltransferase 2
ACE angiotensin I converting enzyme
AHR aryl hydrocarbon receptor
APOA1 apolipoprotein A-I
APOB apolipoprotein B
APOE apolipoprotein E
APP amyloid beta (A4) precursor protein
ATPAF2 ATP synthase mitochondrial F1 complex assembly factor 2
BCHE butyrylcholinesterase
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2
CETP cholesteryl ester transfer protein, plasma
COMT catechol-O-methyltransferase
CST3 cystatin C
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
ESR1 estrogen receptor 1
FOLR1 folate receptor 1 (adult)
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GCKR glucokinase (hexokinase 4) regulator
GRN granulin
HLA-A major histocompatibility complex, class I, A
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
IL6 interleukin 6
LCAT lecithin-cholesterol acyltransferase
LDLR low density lipoprotein receptor
LIPC lipase, hepatic
LIPG lipase, endothelial
LPL lipoprotein lipase
LRP1 low density lipoprotein receptor-related protein 1
MAOA monoamine oxidase A
MAPT microtubule-associated protein tau
MASP2 mannan-binding lectin serine peptidase 2
MBL2 mannose-binding lectin (protein C) 2, soluble
MLXIPL MLX interacting protein-like
MMP9 matrix metallopeptidase 9
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NOS2 nitric oxide synthase 2, inducible
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
PARK7 parkinson protein 7
PCSK9 proprotein convertase subtilisin/kexin type 9
PLTP phospholipid transfer protein
PON1 paraoxonase 1
PPARG peroxisome proliferator-activated receptor gamma
PRNP prion protein
PSEN1 presenilin 1
PSEN2 presenilin 2
PSRC1 proline/serine-rich coiled-coil 1
SCARB1 scavenger receptor class B, member 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SORT1 sortilin 1
SREBF1 sterol regulatory element binding transcription factor 1
SREBF2 sterol regulatory element binding transcription factor 2
TGFB1 transforming growth factor, beta 1
TNF tumor necrosis factor
TOM1L2 target of myb1-like 2 (chicken)
TYMS thymidylate synthetase
VLDLR very low density lipoprotein receptor