dementia Gene Set

Dataset DISEASES Experimental Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A cognitive disorder resulting from a loss of brain function affecting memory, thinking, language, judgement and behavior. (Human Disease Ontology, DOID_1307)
Similar Terms
Downloads & Tools

Genes

201 genes associated with the disease dementia in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
MS4A5 membrane-spanning 4-domains, subfamily A, member 5 1.37597
BCAM basal cell adhesion molecule (Lutheran blood group) 1.14929
APOC1 apolipoprotein C-I 0.894262
HMGA2 high mobility group AT-hook 2 0.894262
TMEM106B transmembrane protein 106B 0.817078
BCL3 B-cell CLL/lymphoma 3 0.774217
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A 0.7623
SYK spleen tyrosine kinase 0.738873
GAB2 GRB2-associated binding protein 2 0.724323
FRMD4A FERM domain containing 4A 0.724323
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.69843
CR1 complement component (3b/4b) receptor 1 (Knops blood group) 0.682635
CLU clusterin 0.65413
EPHA1 EPH receptor A1 0.65413
PICALM phosphatidylinositol binding clathrin assembly protein 0.63207
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 0.602429
CD33 CD33 molecule 0.602429
PPP1R37 protein phosphatase 1, regulatory subunit 37 0.602429
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.602429
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 0.602429
CEACAM16 carcinoembryonic antigen-related cell adhesion molecule 16 0.602429
GLIS3 GLIS family zinc finger 3 0.58494
CD2AP CD2-associated protein 0.5306
SRRM4 serine/arginine repetitive matrix 4 0.52461
ZNF292 zinc finger protein 292 0.464771
BCHE butyrylcholinesterase 0.464771
EDAR ectodysplasin A receptor 0.449873
SCARA3 scavenger receptor class A, member 3 0.449873
EMC1 ER membrane protein complex subunit 1 0.403461
LINC00619 long intergenic non-protein coding RNA 619 0.403461
UPP2 uridine phosphorylase 2 0.403461
APOC4 apolipoprotein C-IV 0.403461
IRS1 insulin receptor substrate 1 0.403461
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B) 0.403461
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.403461
PCDH11X protocadherin 11 X-linked 0.368757
CELF2 CUGBP, Elav-like family member 2 0.368757
EFNA5 ephrin-A5 0.368757
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.345945
PPP1R3B protein phosphatase 1, regulatory subunit 3B 0.345945
F13A1 coagulation factor XIII, A1 polypeptide 0.345945
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 0.345945
EXOC1 exocyst complex component 1 0.345945
PCED1B PC-esterase domain containing 1B 0.345945
WDR1 WD repeat domain 1 0.345945
CLPTM1 cleft lip and palate associated transmembrane protein 1 0.327313
DTWD2 DTW domain containing 2 0.327313
CCR3 chemokine (C-C motif) receptor 3 0.327313
UNC5C unc-5 homolog C (C. elegans) 0.311576
DCHS2 dachsous cadherin-related 2 0.311576
RFC3 replication factor C (activator 1) 3, 38kDa 0.297866
VSNL1 visinin-like 1 0.297866
BOK BCL2-related ovarian killer 0.297866
TMEM74 transmembrane protein 74 0.297866
CADPS2 Ca++-dependent secretion activator 2 0.297866
CDH4 cadherin 4, type 1, R-cadherin (retinal) 0.297866
SHB Src homology 2 domain containing adaptor protein B 0.297866
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase 0.297866
RBBP6 retinoblastoma binding protein 6 0.297866
NALCN sodium leak channel, non selective 0.285417
KLHL23 kelch-like family member 23 0.285417
PRUNE2 prune homolog 2 (Drosophila) 0.285417
CLEC16A C-type lectin domain family 16, member A 0.274608
GLYATL3 glycine-N-acyltransferase-like 3 0.274608
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.274608
LUZP2 leucine zipper protein 2 0.274608
FGF10 fibroblast growth factor 10 0.264872
RFPL3 ret finger protein-like 3 0.264872
WFDC2 WAP four-disulfide core domain 2 0.264872
TTLL7 tubulin tyrosine ligase-like family member 7 0.256228
BIN1 bridging integrator 1 0.256228
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A 0.256228
ITGA1 integrin, alpha 1 0.256228
MPZL1 myelin protein zero-like 1 0.256228
ATP8B4 ATPase, class I, type 8B, member 4 0.256228
APOE apolipoprotein E 0.256228
MUC21 mucin 21, cell surface associated 0.256228
EPC2 enhancer of polycomb homolog 2 (Drosophila) 0.256228
MMP12 matrix metallopeptidase 12 0.256228
SPTLC3 serine palmitoyltransferase, long chain base subunit 3 0.256228
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) 0.256228
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.256228
ATXN7L1 ataxin 7-like 1 0.256228
RSPO2 R-spondin 2 0.256228
STXBP6 syntaxin binding protein 6 (amisyn) 0.256228
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 0.256228
BIRC3 baculoviral IAP repeat containing 3 0.256228
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast) 0.256228
CSMD2 CUB and Sushi multiple domains 2 0.256228
MSX1 msh homeobox 1 0.256228
CCDC134 coiled-coil domain containing 134 0.256228
SLC44A5 solute carrier family 44, member 5 0.197766
AEBP2 AE binding protein 2 0.197766
TNRC6C trinucleotide repeat containing 6C 0.197766
ADCY8 adenylate cyclase 8 (brain) 0.197766
CNTN5 contactin 5 0.197766
LMOD3 leiomodin 3 (fetal) 0.197766
RELN reelin 0.197766
MROH8 maestro heat-like repeat family member 8 0.197766
AKAP2 A kinase (PRKA) anchor protein 2 0.197766
TMEM38B transmembrane protein 38B 0.197766
PALM2 paralemmin 2 0.197766
ZNF326 zinc finger protein 326 0.197766
SCAMP1 secretory carrier membrane protein 1 0.197766
ZBP1 Z-DNA binding protein 1 0.197766
ZNF221 zinc finger protein 221 0.197766
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5 0.197766
DNAH11 dynein, axonemal, heavy chain 11 0.197766
SLC4A1AP solute carrier family 4 (anion exchanger), member 1, adaptor protein 0.197766
PLXNA4 plexin A4 0.197766
MPP7 membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7) 0.197766
NCR2 natural cytotoxicity triggering receptor 2 0.197766
NFIB nuclear factor I/B 0.197766
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 0.197766
RORA RAR-related orphan receptor A 0.15771
LRAT lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) 0.15771
CDON cell adhesion associated, oncogene regulated 0.15771
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) 0.15771
FRMD6 FERM domain containing 6 0.15771
PRSS55 protease, serine, 55 0.15771
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 0.15771
ARID1B AT rich interactive domain 1B (SWI1-like) 0.15771
PTMAP5 prothymosin, alpha pseudogene 5 0.15771
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast) 0.15771
SPTLC1 serine palmitoyltransferase, long chain base subunit 1 0.15771
IKZF1 IKAROS family zinc finger 1 (Ikaros) 0.15771
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.15771
RBMS3 RNA binding motif, single stranded interacting protein 3 0.15771
DMXL1 Dmx-like 1 0.15771
HRK harakiri, BCL2 interacting protein 0.15771
CUBN cubilin (intrinsic factor-cobalamin receptor) 0.15771
KIAA0020 KIAA0020 0.126165
C3ORF17 chromosome 3 open reading frame 17 0.126165
CFAP45 cilia and flagella associated protein 45 0.126165
STK24 serine/threonine kinase 24 0.126165
STX2 syntaxin 2 0.126165
GDA guanine deaminase 0.126165
C3ORF56 chromosome 3 open reading frame 56 0.126165
LINC00588 long intergenic non-protein coding RNA 588 0.126165
CSNK1G3 casein kinase 1, gamma 3 0.126165
SLITRK3 SLIT and NTRK-like family, member 3 0.126165
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.126165
DOK5 docking protein 5 0.100789
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 0.100789
MYOF myoferlin 0.100789
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 0.100789
CCNG1 cyclin G1 0.100789
PDS5B PDS5 cohesin associated factor B 0.100789
ZNF28 zinc finger protein 28 0.100789
ZNF320 zinc finger protein 320 0.100789
CAND1 cullin-associated and neddylation-dissociated 1 0.100789
ROR1 receptor tyrosine kinase-like orphan receptor 1 0.100789
RNF6 ring finger protein (C3H2C3 type) 6 0.100789
DIAPH3 diaphanous-related formin 3 0.100789
S100A6 S100 calcium binding protein A6 0.080593
CLVS1 clavesin 1 0.080593
PAX2 paired box 2 0.080593
PCNX pecanex homolog (Drosophila) 0.080593
POLN polymerase (DNA directed) nu 0.080593
RPN2 ribophorin II 0.080593
COL13A1 collagen, type XIII, alpha 1 0.080593
MS4A4E membrane-spanning 4-domains, subfamily A, member 4E 0.080593
HMGB1 high mobility group box 1 0.064973
SLC17A2 solute carrier family 17, member 2 0.064973
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila) 0.064973
MGST3 microsomal glutathione S-transferase 3 0.064973
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial 0.064973
STAG2 stromal antigen 2 0.064973
C11ORF30 chromosome 11 open reading frame 30 0.064973
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 0.064973
GFRA2 GDNF family receptor alpha 2 0.064973
MRPL14 mitochondrial ribosomal protein L14 0.064973
ARSB arylsulfatase B 0.064973
NAV1 neuron navigator 1 0.052255
KLHL29 kelch-like family member 29 0.052255
CNTNAP4 contactin associated protein-like 4 0.052255
PROX1 prospero homeobox 1 0.052255
TRAM1L1 translocation associated membrane protein 1-like 1 0.052255
CDH8 cadherin 8, type 2 0.052255
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.052255
BASP1 brain abundant, membrane attached signal protein 1 0.052255
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive) 0.052255
NME9 NME/NM23 family member 9 0.052255
SEC11C SEC11 homolog C (S. cerevisiae) 0.052255
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.052255
SASH1 SAM and SH3 domain containing 1 0.052255
PHLPP2 PH domain and leucine rich repeat protein phosphatase 2 0.052255
STK11 serine/threonine kinase 11 0.052255
SCAF11 SR-related CTD-associated factor 11 0.052255
SLC28A1 solute carrier family 28 (concentrative nucleoside transporter), member 1 0.043246
HAS2 hyaluronan synthase 2 0.043246
UTS2B urotensin 2B 0.043246
ST6GAL2 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 0.043246
DISC1 disrupted in schizophrenia 1 0.043246
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.043246
RAD51AP2 RAD51 associated protein 2 0.043246
NCAM1 neural cell adhesion molecule 1 0.043246
C7ORF72 chromosome 7 open reading frame 72 0.043246
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.043246
CNTNAP2 contactin associated protein-like 2 0.043246
CHL1 cell adhesion molecule L1-like 0.035343