degeneration of macula and posterior pole Gene Set

Dataset GWASdb SNP-Disease Associations
Category disease or phenotype associations
Type disease
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/DOID:2007
Similar Terms
Downloads & Tools

Genes

208 genes associated with the disease degeneration of macula and posterior pole in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.

Symbol Name Standardized Value
CFH complement factor H 4.56214
ARMS2 age-related maculopathy susceptibility 2 4.56214
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae) 2.96514
CFHR4 complement factor H-related 4 2.81156
HTRA1 HtrA serine peptidase 1 2.66796
C3 complement component 3 2.45974
CFB complement factor B 2.28468
KCNT2 potassium channel, sodium activated subfamily T, member 2 2.19599
CFHR1 complement factor H-related 1 2.18979
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 2.10895
C2 complement component 2 2.10422
APOC1 apolipoprotein C-I 2.01898
CFHR5 complement factor H-related 5 1.90509
CETP cholesteryl ester transfer protein, plasma 1.84079
SYN3 synapsin III 1.82268
F13B coagulation factor XIII, B polypeptide 1.77978
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 1.75776
ZBTB41 zinc finger and BTB domain containing 41 1.7251
COL8A1 collagen, type VIII, alpha 1 1.71314
CFHR3 complement factor H-related 3 1.6622
SLC16A8 solute carrier family 16 (monocarboxylate transporter), member 8 1.62029
NOTCH4 notch 4 1.62029
TGFBR1 transforming growth factor, beta receptor 1 1.60875
CFHR2 complement factor H-related 2 1.60791
CRB1 crumbs family member 1, photoreceptor morphogenesis associated 1.60057
CCDC109B coiled-coil domain containing 109B 1.5865
RAD51B RAD51 paralog B 1.57873
NELFE negative elongation factor complex member E 1.55738
BTBD16 BTB (POZ) domain containing 16 1.52938
TNXB tenascin XB 1.50906
ADAMTS9-AS2 ADAMTS9 antisense RNA 2 1.45471
STK19 serine/threonine kinase 19 1.44164
REST RE1-silencing transcription factor 1.39396
COL10A1 collagen, type X, alpha 1 1.39396
B3GALTL beta 1,3-galactosyltransferase-like 1.39396
EGFL8 EGF-like-domain, multiple 8 1.39006
RNF5 ring finger protein 5, E3 ubiquitin protein ligase 1.35759
AGPAT1 1-acylglycerol-3-phosphate O-acyltransferase 1 1.35365
PLA2G12A phospholipase A2, group XIIA 1.32681
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast) 1.32598
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 1.30936
GPR152 G protein-coupled receptor 152 1.24183
MAP2 microtubule-associated protein 2 1.23448
ADD3 adducin 3 (gamma) 1.21798
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B) 1.19386
RREB1 ras responsive element binding protein 1 1.19386
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 1.19313
LOC284395 uncharacterized LOC284395 1.19171
SCN4A sodium channel, voltage gated, type IV alpha subunit 1.18343
EHMT2 euchromatic histone-lysine N-methyltransferase 2 1.18062
LY6G6F lymphocyte antigen 6 complex, locus G6F 1.16047
PTGES3 prostaglandin E synthase 3 (cytosolic) 1.14463
CNKSR2 connector enhancer of kinase suppressor of Ras 2 1.1105
FBXO15 F-box protein 15 1.09959
SNTG1 syntrophin, gamma 1 1.09493
ANKRD45 ankyrin repeat domain 45 1.09493
TYR tyrosinase 1.07599
BTBD2 BTB (POZ) domain containing 2 1.06777
C6ORF48 chromosome 6 open reading frame 48 1.05828
DAZAP1 DAZ associated protein 1 1.05742
YY1AP1 YY1 associated protein 1 1.05742
ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I 1.05407
EPB41L4A erythrocyte membrane protein band 4.1 like 4A 1.0538
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast) 1.0538
CAPN7 calpain 7 1.05003
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF 1.04096
SET SET nuclear proto-oncogene 1.03835
MSN moesin 1.03835
METTL16 methyltransferase like 16 1.02362
RIMS3 regulating synaptic membrane exocytosis 3 1.01853
FRAT2 frequently rearranged in advanced T-cell lymphomas 2 1.0181
ELP2 elongator acetyltransferase complex subunit 2 1.01598
NFIB nuclear factor I/B 1.01556
FILIP1L filamin A interacting protein 1-like 1.00788
OSBPL6 oxysterol binding protein-like 6 1.00039
CLIC5 chloride intracellular channel 5 0.986376
SKA1 spindle and kinetochore associated complex subunit 1 0.980941
DOK5 docking protein 5 0.979704
GLI3 GLI family zinc finger 3 0.971169
PRKAG3 protein kinase, AMP-activated, gamma 3 non-catalytic subunit 0.967203
SNORD48 small nucleolar RNA, C/D box 48 0.951514
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.951514
TOMM34 translocase of outer mitochondrial membrane 34 0.93103
GJA8 gap junction protein, alpha 8, 50kDa 0.930169
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2 0.928472
FSTL5 follistatin-like 5 0.927636
ARL15 ADP-ribosylation factor-like 15 0.925987
MYO16 myosin XVI 0.925987
MTA1 metastasis associated 1 0.92437
INHBC inhibin, beta C 0.921998
SLC9C2 solute carrier family 9, member C2 (putative) 0.921998
SCGB2A2 secretoglobin, family 2A, member 2 0.921998
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 0.920453
SLC24A5 solute carrier family 24 (sodium/potassium/calcium exchanger), member 5 0.918934
KLHL20 kelch-like family member 20 0.917442
AIP aryl hydrocarbon receptor interacting protein 0.917442
VAV2 vav 2 guanine nucleotide exchange factor 0.917442
C17ORF64 chromosome 17 open reading frame 64 0.917442
DARS2 aspartyl-tRNA synthetase 2, mitochondrial 0.917442
MAP3K19 mitogen-activated protein kinase kinase kinase 19 0.917442
NAPEPLD N-acyl phosphatidylethanolamine phospholipase D 0.915976
SAPCD1 suppressor APC domain containing 1 0.912987
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.912987
NAA30 N(alpha)-acetyltransferase 30, NatC catalytic subunit 0.90636
ADAMTS17 ADAM metallopeptidase with thrombospondin type 1 motif, 17 0.903565
CNTNAP4 contactin associated protein-like 4 0.898875
NDST3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3 0.88034
ADCY2 adenylate cyclase 2 (brain) 0.876244
UNC13C unc-13 homolog C (C. elegans) 0.869084
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 0.865448
MSH5 mutS homolog 5 0.860976
TRMT13 tRNA methyltransferase 13 homolog (S. cerevisiae) 0.855302
LIPC lipase, hepatic 0.853292
ANTXR1 anthrax toxin receptor 1 0.852303
DCC DCC netrin 1 receptor 0.836877
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 0.822728
TNS1 tensin 1 0.808405
ANKRD16 ankyrin repeat domain 16 0.799893
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.797032
DAOA-AS1 DAOA antisense RNA 1 0.790203
RNF125 ring finger protein 125, E3 ubiquitin protein ligase 0.78442
CLUL1 clusterin-like 1 (retinal) 0.781342
AIF1 allograft inflammatory factor 1 0.778945
IGFBP7 insulin-like growth factor binding protein 7 0.776893
GRID2 glutamate receptor, ionotropic, delta 2 0.776026
KLF12 Kruppel-like factor 12 0.775739
YOD1 YOD1 deubiquitinase 0.775452
LY6G5C lymphocyte antigen 6 complex, locus G5C 0.77125
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 0.77043
RRP1 ribosomal RNA processing 1 0.770158
FSIP1 fibrous sheath interacting protein 1 0.764084
NKAIN3 Na+/K+ transporting ATPase interacting 3 0.762374
KIF21B kinesin family member 21B 0.760414
LOC389641 uncharacterized LOC389641 0.756867
PADI1 peptidyl arginine deiminase, type I 0.756331
MAP2K1 mitogen-activated protein kinase kinase 1 0.754478
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.733341
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 0.732156
FAM155A family with sequence similarity 155, member A 0.726189
FAM177B family with sequence similarity 177, member B 0.723107
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase 0.717191
RMDN2 regulator of microtubule dynamics 2 0.711195
CSMD1 CUB and Sushi multiple domains 1 0.710807
OR1Q1 olfactory receptor, family 1, subfamily Q, member 1 0.707753
AKAP12 A kinase (PRKA) anchor protein 12 0.70297
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.701191
SLC14A2 solute carrier family 14 (urea transporter), member 2 0.699101
PARK2 parkin RBR E3 ubiquitin protein ligase 0.695875
NCAM2 neural cell adhesion molecule 2 0.694217
AOAH acyloxyacyl hydrolase (neutrophil) 0.688615
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4 0.683452
PAK7 p21 protein (Cdc42/Rac)-activated kinase 7 0.682568
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 0.679391
DXO decapping exoribonuclease 0.67728
DIS3L DIS3 like exosome 3'-5' exoribonuclease 0.673859
TEX9 testis expressed 9 0.670943
AKAP13 A kinase (PRKA) anchor protein 13 0.669544
TCF7 transcription factor 7 (T-cell specific, HMG-box) 0.662072
OPCML opioid binding protein/cell adhesion molecule-like 0.654978
GFOD1 glucose-fructose oxidoreductase domain containing 1 0.650844
MCC mutated in colorectal cancers 0.648464
TNIP2 TNFAIP3 interacting protein 2 0.638972
WDPCP WD repeat containing planar cell polarity effector 0.638972
KIAA1549L KIAA1549-like 0.637483
ACPP acid phosphatase, prostate 0.636511
LARGE like-glycosyltransferase 0.630132
LAMP5 lysosomal-associated membrane protein family, member 5 0.628481
PADI4 peptidyl arginine deiminase, type IV 0.628481
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.626482
SLC6A5 solute carrier family 6 (neurotransmitter transporter), member 5 0.625701
PROM1 prominin 1 0.62455
ZW10 zw10 kinetochore protein 0.624172
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.620165
MBTPS1 membrane-bound transcription factor peptidase, site 1 0.619466
RYBP RING1 and YY1 binding protein 0.616096
GRAMD3 GRAM domain containing 3 0.613378
TSPEAR thrombospondin-type laminin G domain and EAR repeats 0.613378
ETV6 ets variant 6 0.613036
USP28 ubiquitin specific peptidase 28 0.611686
ADAM12 ADAM metallopeptidase domain 12 0.609075
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.608756
NXN nucleoredoxin 0.602145
PTPRT protein tyrosine phosphatase, receptor type, T 0.598248
VIT vitrin 0.596242
LRRK1 leucine-rich repeat kinase 1 0.593212
KCNIP1 Kv channel interacting protein 1 0.590838
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.589811
TNR tenascin R 0.589304
FAM193A family with sequence similarity 193, member A 0.587561
DCDC2 doublecortin domain containing 2 0.583062
ANKRD12 ankyrin repeat domain 12 0.57981
ETV1 ets variant 1 0.578411
PRELID2 PRELI domain containing 2 0.572673
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.572673
TACC2 transforming, acidic coiled-coil containing protein 2 0.572462
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) 0.569782
PAPPA2 pappalysin 2 0.568979
LOC100288798 uncharacterized LOC100288798 0.568383
ATXN1 ataxin 1 0.548317
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5 0.540011
ZNF516 zinc finger protein 516 0.538685
RIN3 Ras and Rab interactor 3 0.537959
SV2C synaptic vesicle glycoprotein 2C 0.536247
FAM171A1 family with sequence similarity 171, member A1 0.501829
KDM4B lysine (K)-specific demethylase 4B 0.498853
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2 0.498668
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6 0.498302
FER1L6-AS1 FER1L6 antisense RNA 1 0.496919