decreased vertical activity Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description lesser than average time spent jumping or rearing (Mammalian Phenotype Ontology, MP_0002757)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0002757
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Genes

109 gene mutations causing the decreased vertical activity phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCD1 ATP-binding cassette, sub-family D (ALD), member 1
ADCY5 adenylate cyclase 5
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
ADRA1D adrenoceptor alpha 1D
AP4E1 adaptor-related protein complex 4, epsilon 1 subunit
APOD apolipoprotein D
APOE apolipoprotein E
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4
ATM ATM serine/threonine kinase
ATXN3 ataxin 3
BDNF brain-derived neurotrophic factor
C12ORF10 chromosome 12 open reading frame 10
CACNG2 calcium channel, voltage-dependent, gamma subunit 2
CAMK4 calcium/calmodulin-dependent protein kinase IV
CDH23 cadherin-related 23
CKMT1A creatine kinase, mitochondrial 1A
CLCN6 chloride channel, voltage-sensitive 6
CLPP caseinolytic mitochondrial matrix peptidase proteolytic subunit
CNR1 cannabinoid receptor 1 (brain)
COQ9 coenzyme Q9
CPE carboxypeptidase E
CPLX2 complexin 2
CREB1 cAMP responsive element binding protein 1
CREBBP CREB binding protein
CRHR2 corticotropin releasing hormone receptor 2
CYBB cytochrome b-245, beta polypeptide
DLG4 discs, large homolog 4 (Drosophila)
DRD1 dopamine receptor D1
DRD2 dopamine receptor D2
DRD4 dopamine receptor D4
EHMT1 euchromatic histone-lysine N-methyltransferase 1
ESPN espin
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
FA2H fatty acid 2-hydroxylase
FAM134C family with sequence similarity 134, member C
FKBP9 FK506 binding protein 9, 63 kDa
GAA glucosidase, alpha; acid
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3
GALR2 galanin receptor 2
GJB6 gap junction protein, beta 6, 30kDa
GJC2 gap junction protein, gamma 2, 47kDa
GLB1 galactosidase, beta 1
GNG2 guanine nucleotide binding protein (G protein), gamma 2
GPRASP1 G protein-coupled receptor associated sorting protein 1
GRIA4 glutamate receptor, ionotropic, AMPA 4
GRID2 glutamate receptor, ionotropic, delta 2
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D
GSTA3 glutathione S-transferase alpha 3
GTF2I general transcription factor IIi
GTF2IRD1 GTF2I repeat domain containing 1
HDGF hepatoma-derived growth factor
HEXA hexosaminidase A (alpha polypeptide)
HMGN1 high mobility group nucleosome binding domain 1
HPRT1 hypoxanthine phosphoribosyltransferase 1
HRH1 histamine receptor H1
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
HTT huntingtin
IDUA iduronidase, alpha-L-
IFNG interferon, gamma
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
MECP2 methyl CpG binding protein 2
MFSD2A major facilitator superfamily domain containing 2A
MTM1 myotubularin 1
MYSM1 Myb-like, SWIRM and MPN domains 1
NLGN3 neuroligin 3
NPY neuropeptide Y
NR1D2 nuclear receptor subfamily 1, group D, member 2
NRCAM neuronal cell adhesion molecule
OGG1 8-oxoguanine DNA glycosylase
OTOP1 otopetrin 1
PARK7 parkinson protein 7
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PITX3 paired-like homeodomain 3
PLAT plasminogen activator, tissue
PRNP prion protein
PSIP1 PC4 and SFRS1 interacting protein 1
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
PTPRA protein tyrosine phosphatase, receptor type, A
RTN4R reticulon 4 receptor
SEPN1 selenoprotein N, 1
SEPP1 selenoprotein P, plasma, 1
SEZ6 seizure related 6 homolog (mouse)
SHANK3 SH3 and multiple ankyrin repeat domains 3
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC38A10 solute carrier family 38, member 10
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SMN1 survival of motor neuron 1, telomeric
SNAP25 synaptosomal-associated protein, 25kDa
SP4 Sp4 transcription factor
SSTR2 somatostatin receptor 2
SYTL1 synaptotagmin-like 1
THRB thyroid hormone receptor, beta
TMC8 transmembrane channel-like 8
TNF tumor necrosis factor
TPP1 tripeptidyl peptidase I
TRIB2 tribbles pseudokinase 2
TRMT1L tRNA methyltransferase 1 homolog (S. cerevisiae)-like
TTLL4 tubulin tyrosine ligase-like family member 4
UBR1 ubiquitin protein ligase E3 component n-recognin 1
VANGL2 VANGL planar cell polarity protein 2
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
WFS1 Wolfram syndrome 1 (wolframin)
ZC3HC1 zinc finger, C3HC-type containing 1