decreased tumor necrosis factor secretion Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium (Mammalian Phenotype Ontology, MP_0008561)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008561
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Genes

96 gene mutations causing the decreased tumor necrosis factor secretion phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADORA3 adenosine A3 receptor
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3
APOE apolipoprotein E
AZI2 5-azacytidine induced 2
CARD9 caspase recruitment domain family, member 9
CCAR2 cell cycle and apoptosis regulator 2
CCR1 chemokine (C-C motif) receptor 1
CCR4 chemokine (C-C motif) receptor 4
CCR6 chemokine (C-C motif) receptor 6
CD14 CD14 molecule
CD19 CD19 molecule
CD1D CD1d molecule
CD36 CD36 molecule (thrombospondin receptor)
CD69 CD69 molecule
CLEC4D C-type lectin domain family 4, member D
CLEC4E C-type lectin domain family 4, member E
CLEC6A C-type lectin domain family 6, member A
CLIC4 chloride intracellular channel 4
CNPY3 canopy FGF signaling regulator 3
CORO1A coronin, actin binding protein, 1A
CR2 complement component (3d/Epstein Barr virus) receptor 2
CXCL6 chemokine (C-X-C motif) ligand 6
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58
FADS1 fatty acid desaturase 1
FASTK Fas-activated serine/threonine kinase
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCMR Fc fragment of IgM receptor
FFAR2 free fatty acid receptor 2
GIMAP1-GIMAP5 GIMAP1-GIMAP5 readthrough
GPR65 G protein-coupled receptor 65
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
IDO2 indoleamine 2,3-dioxygenase 2
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFNB1 interferon, beta 1, fibroblast
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL18 interleukin 18
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IRAK2 interleukin-1 receptor-associated kinase 2
IRAK4 interleukin-1 receptor-associated kinase 4
IRF5 interferon regulatory factor 5
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit)
LBP lipopolysaccharide binding protein
LGMN legumain
LTA lymphotoxin alpha
LY96 lymphocyte antigen 96
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MARCH1 membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
MAVS mitochondrial antiviral signaling protein
MIR155 microRNA 155
MMP7 matrix metallopeptidase 7
MYD88 myeloid differentiation primary response 88
MYO1G myosin IG
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NME2 NME/NM23 nucleoside diphosphate kinase 2
NOD1 nucleotide-binding oligomerization domain containing 1
NOD2 nucleotide-binding oligomerization domain containing 2
PDE4B phosphodiesterase 4B, cAMP-specific
PELI1 pellino E3 ubiquitin protein ligase 1
PIGR polymeric immunoglobulin receptor
PILRB paired immunoglobin-like type 2 receptor beta
PLA2G2D phospholipase A2, group IID
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PRKCE protein kinase C, epsilon
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2
RETNLB resistin like beta
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RIPK2 receptor-interacting serine-threonine kinase 2
SASH3 SAM and SH3 domain containing 3
SELK selenoprotein K
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin
SLC15A4 solute carrier family 15 (oligopeptide transporter), member 4
SPP1 secreted phosphoprotein 1
STIM1 stromal interaction molecule 1
SYK spleen tyrosine kinase
TICAM1 toll-like receptor adaptor molecule 1
TICAM2 toll-like receptor adaptor molecule 2
TIMD4 T-cell immunoglobulin and mucin domain containing 4
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein
TLR1 toll-like receptor 1
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TLR6 toll-like receptor 6
TLR7 toll-like receptor 7
TLR9 toll-like receptor 9
TNF tumor necrosis factor
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14
TOLLIP toll interacting protein
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
UNC93B1 unc-93 homolog B1 (C. elegans)
VAV1 vav 1 guanine nucleotide exchange factor