decreased total body fat amount Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description less than the normal total amount of connective tissue composed of fat cells within the entire body (Mammalian Phenotype Ontology, MP_0010025)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0010025
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Genes

224 gene mutations causing the decreased total body fat amount phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACACB acetyl-CoA carboxylase beta
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADCY3 adenylate cyclase 3
AEBP1 AE binding protein 1
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2
AGRP agouti related neuropeptide
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AHCYL1 adenosylhomocysteinase-like 1
AHNAK AHNAK nucleoprotein
AKAP9 A kinase (PRKA) anchor protein 9
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALPL alkaline phosphatase, liver/bone/kidney
AMACR alpha-methylacyl-CoA racemase
AMER1 APC membrane recruitment protein 1
ANGPTL2 angiopoietin-like 2
ANGPTL4 angiopoietin-like 4
APOE apolipoprotein E
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa
ASPA aspartoacylase
ATN1 atrophin 1
ATRN attractin
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BCKDK branched chain ketoacid dehydrogenase kinase
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
C3 complement component 3
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CAV1 caveolin 1, caveolae protein, 22kDa
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CBX6 chromobox homolog 6
CD14 CD14 molecule
CD200 CD200 molecule
CDH23 cadherin-related 23
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1
CERS6 ceramide synthase 6
CHAD chondroadherin
CHD7 chromodomain helicase DNA binding protein 7
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal)
CIDEB cell death-inducing DFFA-like effector b
CIDEC cell death-inducing DFFA-like effector c
CISD2 CDGSH iron sulfur domain 2
CNR1 cannabinoid receptor 1 (brain)
COL1A1 collagen, type I, alpha 1
COL4A5 collagen, type IV, alpha 5
CREB3L1 cAMP responsive element binding protein 3-like 1
CRHR2 corticotropin releasing hormone receptor 2
CRTC3 CREB regulated transcription coactivator 3
CUL7 cullin 7
CUX1 cut-like homeobox 1
CYB5R4 cytochrome b5 reductase 4
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1
DBN1 drebrin 1
DFNB31 deafness, autosomal recessive 31
DLG2 discs, large homolog 2 (Drosophila)
DLG4 discs, large homolog 4 (Drosophila)
DLL1 delta-like 1 (Drosophila)
DNASE1L2 deoxyribonuclease I-like 2
DSG1 desmoglein 1
DSG3 desmoglein 3
DUSP1 dual specificity phosphatase 1
E2F1 E2F transcription factor 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF4H eukaryotic translation initiation factor 4H
EIF6 eukaryotic translation initiation factor 6
ELMOD1 ELMO/CED-12 domain containing 1
ERCC2 excision repair cross-complementation group 2
ERP44 endoplasmic reticulum protein 44
ESYT3 extended synaptotagmin-like protein 3
FAM134C family with sequence similarity 134, member C
FBXO11 F-box protein 11
FECH ferrochelatase
FTO fat mass and obesity associated
GAMT guanidinoacetate N-methyltransferase
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GCGR glucagon receptor
GHSR growth hormone secretagogue receptor
GLP1R glucagon-like peptide 1 receptor
GNAS GNAS complex locus
GPR22 G protein-coupled receptor 22
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D
GRM5 glutamate receptor, metabotropic 5
GTF2IRD1 GTF2I repeat domain containing 1
HADH hydroxyacyl-CoA dehydrogenase
HEXB hexosaminidase B (beta polypeptide)
HRH1 histamine receptor H1
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
HTRA2 HtrA serine peptidase 2
INSR insulin receptor
IRS1 insulin receptor substrate 1
KCNJ12 potassium channel, inwardly rectifying subfamily J, member 12
KIAA1549L KIAA1549-like
KLF15 Kruppel-like factor 15
KLF3 Kruppel-like factor 3 (basic)
KMT2E lysine (K)-specific methyltransferase 2E
LCLAT1 lysocardiolipin acyltransferase 1
LEPROT leptin receptor overlapping transcript
LGALS12 lectin, galactoside-binding, soluble, 12
LGI1 leucine-rich, glioma inactivated 1
LIN28A lin-28 homolog A (C. elegans)
LMNA lamin A/C
LPAR1 lysophosphatidic acid receptor 1
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LTBP1 latent transforming growth factor beta binding protein 1
MAPK8 mitogen-activated protein kinase 8
MARC2 mitochondrial amidoxime reducing component 2
MARK3 MAP/microtubule affinity-regulating kinase 3
MARK4 MAP/microtubule affinity-regulating kinase 4
MBOAT4 membrane bound O-acyltransferase domain containing 4
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MCHR1 melanin-concentrating hormone receptor 1
MCM2 minichromosome maintenance complex component 2
MECOM MDS1 and EVI1 complex locus
MFSD2A major facilitator superfamily domain containing 2A
MIR378A microRNA 378a
MPI mannose phosphate isomerase
MSTN myostatin
MYBPC3 myosin binding protein C, cardiac
MYO6 myosin VI
MYO7A myosin VIIA
MYSM1 Myb-like, SWIRM and MPN domains 1
NCOA3 nuclear receptor coactivator 3
NCOR1 nuclear receptor corepressor 1
NEB nebulin
NMUR2 neuromedin U receptor 2
NOX3 NADPH oxidase 3
NPTN neuroplastin
NPY6R neuropeptide Y receptor Y6 (pseudogene)
NR1H4 nuclear receptor subfamily 1, group H, member 4
NR2C2 nuclear receptor subfamily 2, group C, member 2
NR2E1 nuclear receptor subfamily 2, group E, member 1
NSUN2 NOP2/Sun RNA methyltransferase family, member 2
NTS neurotensin
NXN nucleoredoxin
OPA1 optic atrophy 1 (autosomal dominant)
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
OSTM1 osteopetrosis associated transmembrane protein 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PFN1 profilin 1
PGF placental growth factor
PHEX phosphate regulating endopeptidase homolog, X-linked
PHF2 PHD finger protein 2
PHIP pleckstrin homology domain interacting protein
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PITX3 paired-like homeodomain 3
PLAU plasminogen activator, urokinase
PLIN1 perilipin 1
PLIN2 perilipin 2
POLG polymerase (DNA directed), gamma
PPARG peroxisome proliferator-activated receptor gamma
PRDM4 PR domain containing 4
PREP prolyl endopeptidase
PRKCDBP protein kinase C, delta binding protein
PRKCE protein kinase C, epsilon
PSIP1 PC4 and SFRS1 interacting protein 1
PTHLH parathyroid hormone-like hormone
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PYY peptide YY
RAB6B RAB6B, member RAS oncogene family
RAD23B RAD23 homolog B (S. cerevisiae)
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1
RGS5 regulator of G-protein signaling 5
RLN3 relaxin 3
ROR2 receptor tyrosine kinase-like orphan receptor 2
RRM2B ribonucleotide reductase M2 B (TP53 inducible)
RUNX3 runt-related transcription factor 3
RYR1 ryanodine receptor 1 (skeletal)
SAMD4A sterile alpha motif domain containing 4A
SCP2 sterol carrier protein 2
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae)
SERTAD2 SERTA domain containing 2
SFRP1 secreted frizzled-related protein 1
SFRP2 secreted frizzled-related protein 2
SIRT6 sirtuin 6
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC13A5 solute carrier family 13 (sodium-dependent citrate transporter), member 5
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SLC25A25 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
SLC25A30 solute carrier family 25, member 30
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4
SLC38A10 solute carrier family 38, member 10
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SLC6A19 solute carrier family 6 (neutral amino acid transporter), member 19
SMCO2 single-pass membrane protein with coiled-coil domains 2
SOCS3 suppressor of cytokine signaling 3
SOD2 superoxide dismutase 2, mitochondrial
SOX8 SRY (sex determining region Y)-box 8
SPTB spectrin, beta, erythrocytic
SRA1 steroid receptor RNA activator 1
STAG1 stromal antigen 1
STARD13 StAR-related lipid transfer (START) domain containing 13
STAT5B signal transducer and activator of transcription 5B
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila)
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TGFB1 transforming growth factor, beta 1
TMEM189 transmembrane protein 189
TMUB1 transmembrane and ubiquitin-like domain containing 1
TNIK TRAF2 and NCK interacting kinase
TPGS1 tubulin polyglutamylase complex subunit 1
TRIB1 tribbles pseudokinase 1
TRPC3 transient receptor potential cation channel, subfamily C, member 3
TTLL4 tubulin tyrosine ligase-like family member 4
TWIST2 twist family bHLH transcription factor 2
UBE3B ubiquitin protein ligase E3B
UBR1 ubiquitin protein ligase E3 component n-recognin 1
UMOD uromodulin
UNC79 unc-79 homolog (C. elegans)
USH1C Usher syndrome 1C (autosomal recessive, severe)
VGF VGF nerve growth factor inducible
VIPR2 vasoactive intestinal peptide receptor 2
XDH xanthine dehydrogenase
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
XYLB xylulokinase homolog (H. influenzae)
ZFAND5 zinc finger, AN1-type domain 5