decreased thymocyte number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description fewer than expected number of immature T cells located in the thymus (Mammalian Phenotype Ontology, MP_0000715)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0000715
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Genes

108 gene mutations causing the decreased thymocyte number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
APEX2 APEX nuclease (apurinic/apyrimidinic endonuclease) 2
ATM ATM serine/threonine kinase
BCL10 B-cell CLL/lymphoma 10
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BCL2 B-cell CLL/lymphoma 2
BRAF B-Raf proto-oncogene, serine/threonine kinase
CACYBP calcyclin binding protein
CASP3 caspase 3, apoptosis-related cysteine peptidase
CCR9 chemokine (C-C motif) receptor 9
CD247 CD247 molecule
CD3G CD3g molecule, gamma (CD3-TCR complex)
CD5L CD5 molecule-like
CD8B CD8b molecule
CDK6 cyclin-dependent kinase 6
COL10A1 collagen, type X, alpha 1
COMMD3-BMI1 COMMD3-BMI1 readthrough
CORO1A coronin, actin binding protein, 1A
CREBBP CREB binding protein
CRIP3 cysteine-rich protein 3
CUX1 cut-like homeobox 1
DCLRE1C DNA cross-link repair 1C
DMTF1 cyclin D binding myb-like transcription factor 1
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
E2F4 E2F transcription factor 4, p107/p130-binding
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1)
EP300 E1A binding protein p300
ESR1 estrogen receptor 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXN1 forkhead box N1
FOXP3 forkhead box P3
FYB FYN binding protein
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GATA3 GATA binding protein 3
GFI1 growth factor independent 1 transcription repressor
GRAP2 GRB2-related adaptor protein 2
HAX1 HCLS1 associated protein X-1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL2RG interleukin 2 receptor, gamma
IL6ST interleukin 6 signal transducer
IL7 interleukin 7
IL7R interleukin 7 receptor
ING1 inhibitor of growth family, member 1
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
JAK1 Janus kinase 1
JAK3 Janus kinase 3
KIFAP3 kinesin-associated protein 3
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KITLG KIT ligand
KLF13 Kruppel-like factor 13
KMT2E lysine (K)-specific methyltransferase 2E
LAIR1 leukocyte-associated immunoglobulin-like receptor 1
LAT linker for activation of T cells
LCK LCK proto-oncogene, Src family tyrosine kinase
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LIG4 ligase IV, DNA, ATP-dependent
MAML1 mastermind-like 1 (Drosophila)
MCM4 minichromosome maintenance complex component 4
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MSI2 musashi RNA-binding protein 2
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYB v-myb avian myeloblastosis viral oncogene homolog
NCAPH2 non-SMC condensin II complex, subunit H2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NHEJ1 nonhomologous end-joining factor 1
NLK nemo-like kinase
NOTCH1 notch 1
NOTCH3 notch 3
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PAX1 paired box 1
PCGF2 polycomb group ring finger 2
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PRKCH protein kinase C, eta
PRKCQ protein kinase C, theta
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTCRA pre T-cell antigen receptor alpha
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTPRC protein tyrosine phosphatase, receptor type, C
RAG2 recombination activating gene 2
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RASSF5 Ras association (RalGDS/AF-6) domain family member 5
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
RUNX1 runt-related transcription factor 1
RUNX2 runt-related transcription factor 2
SATB1 SATB homeobox 1
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2
SOCS1 suppressor of cytokine signaling 1
SPI1 Spi-1 proto-oncogene
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5B signal transducer and activator of transcription 5B
SYK spleen tyrosine kinase
TACC3 transforming, acidic coiled-coil containing protein 3
TCF12 transcription factor 12
THEMIS thymocyte selection associated
TRAF2 TNF receptor-associated factor 2
TRAF3 TNF receptor-associated factor 3
TWSG1 twisted gastrulation BMP signaling modulator 1
VAV1 vav 1 guanine nucleotide exchange factor
WIPF1 WAS/WASL interacting protein family, member 1
WNT1 wingless-type MMTV integration site family, member 1
WNT4 wingless-type MMTV integration site family, member 4
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZBTB1 zinc finger and BTB domain containing 1
ZEB1 zinc finger E-box binding homeobox 1