decreased t follicular helper cell number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduced number of the CD4-positive, CXCR5-positive, CCR7-negative alpha-beta T cells located in follicles of secondary lymph nodes that expresses high levels of BCL-6, ICOS and PD1 and stimulate follicular B cells to undergo class-switching and antibody production (Mammalian Phenotype Ontology, MP_0010187)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0010187
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Genes

4 gene mutations causing the decreased t follicular helper cell number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
BATF basic leucine zipper transcription factor, ATF-like
BCL6 B-cell CLL/lymphoma 6
ITFG2 integrin alpha FG-GAP repeat containing 2
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15