decreased t cell proliferation Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduction in the ability of a naive T cell population to undergo rapid expansion by cell division in response to stimuli (Mammalian Phenotype Ontology, MP_0005095)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0005095
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Genes

148 gene mutations causing the decreased t cell proliferation phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACKR4 atypical chemokine receptor 4
AHNAK AHNAK nucleoprotein
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
BCL10 B-cell CLL/lymphoma 10
BCL2L1 BCL2-like 1
BCL6B B-cell CLL/lymphoma 6, member B
BCLAF1 BCL2-associated transcription factor 1
BHLHE40 basic helix-loop-helix family, member e40
BHLHE41 basic helix-loop-helix family, member e41
BTLA B and T lymphocyte associated
CADM1 cell adhesion molecule 1
CARD11 caspase recruitment domain family, member 11
CCL5 chemokine (C-C motif) ligand 5
CCND3 cyclin D3
CCR2 chemokine (C-C motif) receptor 2
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD226 CD226 molecule
CD247 CD247 molecule
CD28 CD28 molecule
CD2AP CD2-associated protein
CD4 CD4 molecule
CD44 CD44 molecule (Indian blood group)
CD48 CD48 molecule
CD5 CD5 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD83 CD83 molecule
CD86 CD86 molecule
CDK6 cyclin-dependent kinase 6
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CIITA class II, major histocompatibility complex, transactivator
CORO1A coronin, actin binding protein, 1A
CRH corticotropin releasing hormone
DBNL drebrin-like
DCLRE1C DNA cross-link repair 1C
DIAPH1 diaphanous-related formin 1
DOCK8 dedicator of cytokinesis 8
DUSP10 dual specificity phosphatase 10
E2F1 E2F transcription factor 1
EPHB6 EPH receptor B6
ERAP1 endoplasmic reticulum aminopeptidase 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FYB FYN binding protein
FYN FYN proto-oncogene, Src family tyrosine kinase
G6PC2 glucose-6-phosphatase, catalytic, 2
HAVCR2 hepatitis A virus cellular receptor 2
HCLS1 hematopoietic cell-specific Lyn substrate 1
HLA-DMA major histocompatibility complex, class II, DM alpha
HR hair growth associated
HRH1 histamine receptor H1
ICOS inducible T-cell co-stimulator
IGHM immunoglobulin heavy constant mu
IL10 interleukin 10
IL15RA interleukin 15 receptor, alpha
IL1R1 interleukin 1 receptor, type I
IL2 interleukin 2
IL21R interleukin 21 receptor
IL23A interleukin 23, alpha subunit p19
IL2RB interleukin 2 receptor, beta
IL2RG interleukin 2 receptor, gamma
IL4R interleukin 4 receptor
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1
IRF4 interferon regulatory factor 4
ITGAD integrin, alpha D
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITK IL2-inducible T-cell kinase
JAK3 Janus kinase 3
KSR1 kinase suppressor of ras 1
LAT linker for activation of T cells
LBR lamin B receptor
LCK LCK proto-oncogene, Src family tyrosine kinase
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LEP leptin
LEPR leptin receptor
LIF leukemia inhibitory factor
LIG4 ligase IV, DNA, ATP-dependent
LRFN2 leucine rich repeat and fibronectin type III domain containing 2
LY9 lymphocyte antigen 9
MALT1 MALT1 paracaspase
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MMP19 matrix metallopeptidase 19
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCKAP1L NCK-associated protein 1-like
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBID nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta
NUP98 nucleoporin 98kDa
PDCD1LG2 programmed cell death 1 ligand 2
PGAP3 post-GPI attachment to proteins 3
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLAU plasminogen activator, urokinase
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme
PRKCE protein kinase C, epsilon
PRKCH protein kinase C, eta
PRKCQ protein kinase C, theta
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTPN9 protein tyrosine phosphatase, non-receptor type 9
PTPRC protein tyrosine phosphatase, receptor type, C
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RAG2 recombination activating gene 2
RAP1A RAP1A, member of RAS oncogene family
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RCAN1 regulator of calcineurin 1
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHOH ras homolog family member H
RIPK2 receptor-interacting serine-threonine kinase 2
RLTPR RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
SASH3 SAM and SH3 domain containing 3
SELK selenoprotein K
SELL selectin L
SH2D2A SH2 domain containing 2A
SKAP1 src kinase associated phosphoprotein 1
SKIL SKI-like proto-oncogene
STAT5B signal transducer and activator of transcription 5B
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SUCNR1 succinate receptor 1
TERC telomerase RNA component
TESPA1 thymocyte expressed, positive selection associated 1
THEMIS thymocyte selection associated
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFRSF4 tumor necrosis factor receptor superfamily, member 4
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TP53 tumor protein p53
TYROBP TYRO protein tyrosine kinase binding protein
UBE2N ubiquitin-conjugating enzyme E2N
VAV1 vav 1 guanine nucleotide exchange factor
WAS Wiskott-Aldrich syndrome
WIPF1 WAS/WASL interacting protein family, member 1
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa