decreased susceptibility to weight gain Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description smaller increase in body weight over time when compared to the average increase in weight on the same diet, with equal energy (calorie) intake (Mammalian Phenotype Ontology, MP_0010182)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0010182
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Genes

113 gene mutations causing the decreased susceptibility to weight gain phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
A2M alpha-2-macroglobulin
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACOT11 acyl-CoA thioesterase 11
ADIPOR2 adiponectin receptor 2
AEBP1 AE binding protein 1
AGTR2 angiotensin II receptor, type 2
AHNAK AHNAK nucleoprotein
AHSG alpha-2-HS-glycoprotein
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
ARID5B AT rich interactive domain 5B (MRF1-like)
ARRDC3 arrestin domain containing 3
BCAT2 branched chain amino-acid transaminase 2, mitochondrial
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CAV1 caveolin 1, caveolae protein, 22kDa
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CERS6 ceramide synthase 6
CIDEC cell death-inducing DFFA-like effector c
CLPP caseinolytic mitochondrial matrix peptidase proteolytic subunit
CNOT3 CCR4-NOT transcription complex, subunit 3
CNR1 cannabinoid receptor 1 (brain)
COL1A1 collagen, type I, alpha 1
COL5A3 collagen, type V, alpha 3
CRBN cereblon
CREBBP CREB binding protein
CRTC3 CREB regulated transcription coactivator 3
DGAT1 diacylglycerol O-acyltransferase 1
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DUSP1 dual specificity phosphatase 1
EPM2AIP1 EPM2A (laforin) interacting protein 1
ESRRA estrogen-related receptor alpha
FABP2 fatty acid binding protein 2, intestinal
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FOXS1 forkhead box S1
FTO fat mass and obesity associated
GALP galanin-like peptide
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GDF3 growth differentiation factor 3
GHSR growth hormone secretagogue receptor
GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
GPR21 G protein-coupled receptor 21
GPR50 G protein-coupled receptor 50
HADH hydroxyacyl-CoA dehydrogenase
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor
HMGA2 high mobility group AT-hook 2
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
INPP5K inositol polyphosphate-5-phosphatase K
INPPL1 inositol polyphosphate phosphatase-like 1
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
LCLAT1 lysocardiolipin acyltransferase 1
LDLR low density lipoprotein receptor
LIPE lipase, hormone-sensitive
LRP6 low density lipoprotein receptor-related protein 6
MAPK13 mitogen-activated protein kinase 13
MAPK8 mitogen-activated protein kinase 8
MARK2 MAP/microtubule affinity-regulating kinase 2
MARK3 MAP/microtubule affinity-regulating kinase 3
MARK4 MAP/microtubule affinity-regulating kinase 4
MBOAT4 membrane bound O-acyltransferase domain containing 4
MCHR1 melanin-concentrating hormone receptor 1
MFSD2A major facilitator superfamily domain containing 2A
MIR378A microRNA 378a
MOGAT2 monoacylglycerol O-acyltransferase 2
MTM1 myotubularin 1
NCOA3 nuclear receptor coactivator 3
NCOR1 nuclear receptor corepressor 1
NMUR2 neuromedin U receptor 2
NPC1L1 NPC1-like 1
NR1H4 nuclear receptor subfamily 1, group H, member 4
NR2C2 nuclear receptor subfamily 2, group C, member 2
OPA1 optic atrophy 1 (autosomal dominant)
PASK PAS domain containing serine/threonine kinase
PCNA proliferating cell nuclear antigen
PDE10A phosphodiesterase 10A
PGF placental growth factor
PLIN1 perilipin 1
PLIN2 perilipin 2
PNLIP pancreatic lipase
PNRC2 proline-rich nuclear receptor coactivator 2
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PRCP prolylcarboxypeptidase (angiotensinase C)
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTPN1 protein tyrosine phosphatase, non-receptor type 1
RCAN2 regulator of calcineurin 2
RGPD1 RANBP2-like and GRIP domain containing 1
RLN3 relaxin 3
RMI1 RecQ mediated genome instability 1
SAMD4A sterile alpha motif domain containing 4A
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC3 syndecan 3
SEPN1 selenoprotein N, 1
SERTAD2 SERTA domain containing 2
SGMS2 sphingomyelin synthase 2
SIK3 SIK family kinase 3
SLC13A5 solute carrier family 13 (sodium-dependent citrate transporter), member 5
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC25A25 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SOCS3 suppressor of cytokine signaling 3
SRA1 steroid receptor RNA activator 1
SSFA2 sperm specific antigen 2
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
TNF tumor necrosis factor
TRPV1 transient receptor potential cation channel, subfamily V, member 1
UCP1 uncoupling protein 1 (mitochondrial, proton carrier)
ZFAND5 zinc finger, AN1-type domain 5