decreased susceptibility to injury Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description less than the normal reaction to trauma, especially that by physical means (Mammalian Phenotype Ontology, MP_0005166)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0005166
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Genes

120 gene mutations causing the decreased susceptibility to injury phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACE angiotensin I converting enzyme
ADORA2A adenosine A2a receptor
ADORA2B adenosine A2b receptor
ADORA3 adenosine A3 receptor
AGTR2 angiotensin II receptor, type 2
APOE apolipoprotein E
AQP4 aquaporin 4
BID BH3 interacting domain death agonist
C3 complement component 3
C5 complement component 5
C6 complement component 6
CAMK2D calcium/calmodulin-dependent protein kinase II delta
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CAMTA2 calmodulin binding transcription activator 2
CCR2 chemokine (C-C motif) receptor 2
CD300A CD300a molecule
CD300LB CD300 molecule-like family member b
CD40 CD40 molecule, TNF receptor superfamily member 5
CD40LG CD40 ligand
CD44 CD44 molecule (Indian blood group)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CFP complement factor properdin
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
COL1A1 collagen, type I, alpha 1
CR2 complement component (3d/Epstein Barr virus) receptor 2
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein)
CST3 cystatin C
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CX3CL1 chemokine (C-X3-C motif) ligand 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCR3 chemokine (C-X-C motif) receptor 3
DAPK1 death-associated protein kinase 1
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EPAS1 endothelial PAS domain protein 1
F11 coagulation factor XI
F12 coagulation factor XII (Hageman factor)
F2RL1 coagulation factor II (thrombin) receptor-like 1
FASLG Fas ligand (TNF superfamily, member 6)
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FCMR Fc fragment of IgM receptor
FHL1 four and a half LIM domains 1
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
GATA4 GATA binding protein 4
GPR180 G protein-coupled receptor 180
GPX3 glutathione peroxidase 3
GRK5 G protein-coupled receptor kinase 5
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HPRT1 hypoxanthine phosphoribosyltransferase 1
IFNG interferon, gamma
IGHM immunoglobulin heavy constant mu
IL13 interleukin 13
IL18 interleukin 18
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL4 interleukin 4
IL6 interleukin 6
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGB6 integrin, beta 6
JUND jun D proto-oncogene
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KLF5 Kruppel-like factor 5 (intestinal)
LBP lipopolysaccharide binding protein
LGALS3 lectin, galactoside-binding, soluble, 3
LIF leukemia inhibitory factor
MAOA monoamine oxidase A
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
MAPK9 mitogen-activated protein kinase 9
MASP2 mannan-binding lectin serine peptidase 2
MEP1B meprin A, beta
MGAT5B mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B
MIR22 microRNA 22
MLKL mixed lineage kinase domain-like
MMP3 matrix metallopeptidase 3
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MURC muscle-related coiled-coil protein
MYD88 myeloid differentiation primary response 88
MYLK myosin light chain kinase
NAMPT nicotinamide phosphoribosyltransferase
NBEAL2 neurobeachin-like 2
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NLRP1 NLR family, pyrin domain containing 1
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NOS1 nitric oxide synthase 1 (neuronal)
NOS2 nitric oxide synthase 2, inducible
NOX4 NADPH oxidase 4
OLFM1 olfactomedin 1
PANX2 pannexin 2
PARP1 poly (ADP-ribose) polymerase 1
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLAT plasminogen activator, tissue
PLD1 phospholipase D1, phosphatidylcholine-specific
POSTN periostin, osteoblast specific factor
PPIF peptidylprolyl isomerase F
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme
PRKCA protein kinase C, alpha
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RCAN1 regulator of calcineurin 1
RETNLB resistin like beta
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SMAD3 SMAD family member 3
SNTA1 syntrophin, alpha 1
STIM2 stromal interaction molecule 2
TGM2 transglutaminase 2
THBS1 thrombospondin 1
TICAM1 toll-like receptor adaptor molecule 1
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TREM1 triggering receptor expressed on myeloid cells 1
TRPV4 transient receptor potential cation channel, subfamily V, member 4
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VWF von Willebrand factor
WDR83 WD repeat domain 83
WWTR1 WW domain containing transcription regulator 1