decreased susceptibility to infection Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduced likelihood that an organism will develop ill effects from a pathogenic invasion or from components of or toxins produced by pathogens (Mammalian Phenotype Ontology, MP_0002409)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0002409
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Genes

159 gene mutations causing the decreased susceptibility to infection phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADGRE5 adhesion G protein-coupled receptor E5
AIRE autoimmune regulator
ANK1 ankyrin 1, erythrocytic
ANTXR2 anthrax toxin receptor 2
APCS amyloid P component, serum
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AQP9 aquaporin 9
ARHGAP15 Rho GTPase activating protein 15
ATP7A ATPase, Cu++ transporting, alpha polypeptide
B2M beta-2-microglobulin
BAHD1 bromo adjacent homology domain containing 1
BCL2A1 BCL2-related protein A1
C4A complement component 4A (Rodgers blood group)
CASP12 caspase 12 (gene/pseudogene)
CBX1 chromobox homolog 1
CCL3L3 chemokine (C-C motif) ligand 3-like 3
CCR1 chemokine (C-C motif) receptor 1
CCR4 chemokine (C-C motif) receptor 4
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CCR6 chemokine (C-C motif) receptor 6
CCR7 chemokine (C-C motif) receptor 7
CD14 CD14 molecule
CD200R1 CD200 receptor 1
CD274 CD274 molecule
CD47 CD47 molecule
CD81 CD81 molecule
CDKN2A cyclin-dependent kinase inhibitor 2A
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CHD7 chromodomain helicase DNA binding protein 7
CHIT1 chitinase 1 (chitotriosidase)
CIITA class II, major histocompatibility complex, transactivator
CLEC4E C-type lectin domain family 4, member E
CLEC4G C-type lectin domain family 4, member G
COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
CORO1A coronin, actin binding protein, 1A
CSRP2BP CSRP2 binding protein
CTSG cathepsin G
CXCL16 chemokine (C-X-C motif) ligand 16
CXCL6 chemokine (C-X-C motif) ligand 6
CXCR2 chemokine (C-X-C motif) receptor 2
CXCR3 chemokine (C-X-C motif) receptor 3
CXCR4 chemokine (C-X-C motif) receptor 4
CYLD cylindromatosis (turban tumor syndrome)
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DGKZ diacylglycerol kinase, zeta
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58
DICER1 dicer 1, ribonuclease type III
DMD dystrophin
DONSON downstream neighbor of SON
EBAG9 estrogen receptor binding site associated, antigen, 9
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa
ELANE elastase, neutrophil expressed
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FCMR Fc fragment of IgM receptor
FGL2 fibrinogen-like 2
FOXN1 forkhead box N1
GAB2 GRB2-associated binding protein 2
GLT8D2 glycosyltransferase 8 domain containing 2
GRB2 growth factor receptor-bound protein 2
GUCY2C guanylate cyclase 2C
HAVCR2 hepatitis A virus cellular receptor 2
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
ICAM1 intercellular adhesion molecule 1
IFNB1 interferon, beta 1, fibroblast
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IL13 interleukin 13
IL13RA1 interleukin 13 receptor, alpha 1
IL15 interleukin 15
IL18 interleukin 18
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL27RA interleukin 27 receptor, alpha
IL34 interleukin 34
IL4 interleukin 4
IL6R interleukin 6 receptor
INPP1 inositol polyphosphate-1-phosphatase
IRF5 interferon regulatory factor 5
ITGAD integrin, alpha D
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
JAK3 Janus kinase 3
JCHAIN joining chain of multimeric IgA and IgM
KHSRP KH-type splicing regulatory protein
KIF1C kinesin family member 1C
KLRK1 killer cell lectin-like receptor subfamily K, member 1
LTA lymphotoxin alpha
LYST lysosomal trafficking regulator
MBP myelin basic protein
MBTPS1 membrane-bound transcription factor peptidase, site 1
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MMP28 matrix metallopeptidase 28
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MRC1 mannose receptor, C type 1
MST1R macrophage stimulating 1 receptor
MX1 MX dynamin-like GTPase 1
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
MYD88 myeloid differentiation primary response 88
MYO7A myosin VIIA
NCF1 neutrophil cytosolic factor 1
NCR1 natural cytotoxicity triggering receptor 1
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
OASL 2'-5'-oligoadenylate synthetase-like
OTUD7B OTU deubiquitinase 7B
PADI4 peptidyl arginine deiminase, type IV
PELI3 pellino E3 ubiquitin protein ligase family member 3
PGLYRP2 peptidoglycan recognition protein 2
PIAS1 protein inhibitor of activated STAT, 1
PILRB paired immunoglobin-like type 2 receptor beta
PKLR pyruvate kinase, liver and RBC
PLCB2 phospholipase C, beta 2
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1
PLP1 proteolipid protein 1
PRF1 perforin 1 (pore forming protein)
PRNP prion protein
PTAFR platelet-activating factor receptor
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
RAG2 recombination activating gene 2
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RETNLB resistin like beta
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
S100A9 S100 calcium binding protein A9
SDC1 syndecan 1
SH2D1A SH2 domain containing 1A
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin
SLAMF6 SLAM family member 6
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLCO2B1 solute carrier organic anion transporter family, member 2B1
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOCS1 suppressor of cytokine signaling 1
SPP1 secreted phosphoprotein 1
SPTA1 spectrin, alpha, erythrocytic 1
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TERF2IP telomeric repeat binding factor 2, interacting protein
TICAM1 toll-like receptor adaptor molecule 1
TIMP1 TIMP metallopeptidase inhibitor 1
TLR2 toll-like receptor 2
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TLR5 toll-like receptor 5
TLR9 toll-like receptor 9
TNF tumor necrosis factor
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRAFD1 TRAF-type zinc finger domain containing 1
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
USP21 ubiquitin specific peptidase 21
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VTCN1 V-set domain containing T cell activation inhibitor 1
XCR1 chemokine (C motif) receptor 1