decreased susceptibility to autoimmune disorder Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduced likelihood that an organism will develop disease characterized by production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides (Mammalian Phenotype Ontology, MP_0005351)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0005351
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Genes

142 gene mutations causing the decreased susceptibility to autoimmune disorder phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACAN aggrecan
ADAM8 ADAM metallopeptidase domain 8
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
AIF1 allograft inflammatory factor 1
ALOX5 arachidonate 5-lipoxygenase
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ARID5A AT rich interactive domain 5A (MRF1-like)
B2M beta-2-microglobulin
BATF basic leucine zipper transcription factor, ATF-like
BCL2L1 BCL2-like 1
BMX BMX non-receptor tyrosine kinase
BTK Bruton agammaglobulinemia tyrosine kinase
C3 complement component 3
C3AR1 complement component 3a receptor 1
CCL13 chemokine (C-C motif) ligand 13
CCR1 chemokine (C-C motif) receptor 1
CCR2 chemokine (C-C motif) receptor 2
CCR6 chemokine (C-C motif) receptor 6
CCR8 chemokine (C-C motif) receptor 8
CD1D CD1d molecule
CD28 CD28 molecule
CD4 CD4 molecule
CD40LG CD40 ligand
CD44 CD44 molecule (Indian blood group)
CD5 CD5 molecule
CD69 CD69 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD86 CD86 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFB complement factor B
CFP complement factor properdin
CIITA class II, major histocompatibility complex, transactivator
CLEC4D C-type lectin domain family 4, member D
CLEC4E C-type lectin domain family 4, member E
CLEC5A C-type lectin domain family 5, member A
CORO1A coronin, actin binding protein, 1A
CRH corticotropin releasing hormone
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CTSB cathepsin B
CTSS cathepsin S
CTSV cathepsin V
CXCR2 chemokine (C-X-C motif) receptor 2
DNASE1 deoxyribonuclease I
DUSP10 dual specificity phosphatase 10
DUSP2 dual specificity phosphatase 2
EPHB6 EPH receptor B6
F2 coagulation factor II (thrombin)
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAS Fas cell surface death receptor
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
GHR growth hormone receptor
GHRH growth hormone releasing hormone
GHRHR growth hormone releasing hormone receptor
GPSM3 G-protein signaling modulator 3
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-E major histocompatibility complex, class I, E
HRH3 histamine receptor H3
ICA1 islet cell autoantigen 1, 69kDa
ICOS inducible T-cell co-stimulator
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1)
IGHM immunoglobulin heavy constant mu
IL13 interleukin 13
IL17A interleukin 17A
IL17C interleukin 17C
IL17F interleukin 17F
IL17RC interleukin 17 receptor C
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL21 interleukin 21
IL21R interleukin 21 receptor
IL23A interleukin 23, alpha subunit p19
IL23R interleukin 23 receptor
IL27RA interleukin 27 receptor, alpha
IL4 interleukin 4
IL6 interleukin 6
IRAK1 interleukin-1 receptor-associated kinase 1
IRF1 interferon regulatory factor 1
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit)
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KSR1 kinase suppressor of ras 1
LTA lymphotoxin alpha
LTB4R leukotriene B4 receptor
LTB4R2 leukotriene B4 receptor 2
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3
MERTK MER proto-oncogene, tyrosine kinase
MMP9 matrix metallopeptidase 9
MOG myelin oligodendrocyte glycoprotein
MPG N-methylpurine-DNA glycosylase
MT-ND2 MTND2
MYD88 myeloid differentiation primary response 88
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NINJ1 ninjurin 1
NLRP10 NLR family, pyrin domain containing 10
NOD2 nucleotide-binding oligomerization domain containing 2
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PGLYRP2 peptidoglycan recognition protein 2
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLAU plasminogen activator, urokinase
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PRF1 perforin 1 (pore forming protein)
PRKCQ protein kinase C, theta
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RASGRP4 RAS guanyl releasing protein 4
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RFTN1 raftlin, lipid raft linker 1
SELL selectin L
SHCBP1 SHC SH2-domain binding protein 1
SKAP2 src kinase associated phosphoprotein 2
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SPN sialophorin
SPP1 secreted phosphoprotein 1
STAT4 signal transducer and activator of transcription 4
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STK17B serine/threonine kinase 17b
SYVN1 synovial apoptosis inhibitor 1, synoviolin
TBX21 T-box 21
TLR4 toll-like receptor 4
TLR9 toll-like receptor 9
TNF tumor necrosis factor
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TPSAB1 tryptase alpha/beta 1
TRAF3IP2 TRAF3 interacting protein 2
TYK2 tyrosine kinase 2
TYROBP TYRO protein tyrosine kinase binding protein
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa