decreased susceptibility to autoimmune diabetes Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduced likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas (Mammalian Phenotype Ontology, MP_0004804)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0004804
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Genes

32 gene mutations causing the decreased susceptibility to autoimmune diabetes phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
B2M beta-2-microglobulin
CD4 CD4 molecule
CD40LG CD40 ligand
CD86 CD86 molecule
CIITA class II, major histocompatibility complex, transactivator
CTSB cathepsin B
CTSS cathepsin S
CTSV cathepsin V
FAS Fas cell surface death receptor
GHR growth hormone receptor
ICA1 islet cell autoantigen 1, 69kDa
ICOS inducible T-cell co-stimulator
IFNG interferon, gamma
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1)
IGHM immunoglobulin heavy constant mu
IL1R1 interleukin 1 receptor, type I
IL21R interleukin 21 receptor
MERTK MER proto-oncogene, tyrosine kinase
MPG N-methylpurine-DNA glycosylase
MT-ND2 MTND2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PRF1 perforin 1 (pore forming protein)
REL v-rel avian reticuloendotheliosis viral oncogene homolog
SELL selectin L
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
STAT4 signal transducer and activator of transcription 4
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor