decreased survivor rate Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls (Mammalian Phenotype Ontology, MP_0008770)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008770
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Genes

165 gene mutations causing the decreased survivor rate phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACE angiotensin I converting enzyme
ACHE acetylcholinesterase (Yt blood group)
ACKR3 atypical chemokine receptor 3
ACSL4 acyl-CoA synthetase long-chain family member 4
ADAM17 ADAM metallopeptidase domain 17
AEBP1 AE binding protein 1
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2
ALKBH1 alkB, alkylation repair homolog 1 (E. coli)
APAF1 apoptotic peptidase activating factor 1
ATF5 activating transcription factor 5
AVIL advillin
B3GNT5 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
BAIAP2 BAI1-associated protein 2
BMP2 bone morphogenetic protein 2
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CBY1 chibby homolog 1 (Drosophila)
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CDKN2A cyclin-dependent kinase inhibitor 2A
CHD2 chromodomain helicase DNA binding protein 2
CLIC4 chloride intracellular channel 4
CNR1 cannabinoid receptor 1 (brain)
CNTNAP1 contactin associated protein 1
COIL coilin
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
COL5A2 collagen, type V, alpha 2
COL7A1 collagen, type VII, alpha 1
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1
CREB1 cAMP responsive element binding protein 1
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1
DAAM1 dishevelled associated activator of morphogenesis 1
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila)
DACT1 dishevelled-binding antagonist of beta-catenin 1
DDR2 discoidin domain receptor tyrosine kinase 2
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila)
DLG3 discs, large homolog 3 (Drosophila)
DNM3OS DNM3 opposite strand/antisense RNA
EBP emopamil binding protein (sterol isomerase)
EGLN3 egl-9 family hypoxia-inducible factor 3
EIF3C eukaryotic translation initiation factor 3, subunit C
F2R coagulation factor II (thrombin) receptor
FBXW8 F-box and WD repeat domain containing 8
FLNB filamin B, beta
FOXB1 forkhead box B1
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GAP43 growth associated protein 43
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GATA1 GATA binding protein 1 (globin transcription factor 1)
GATA2 GATA binding protein 2
GDF3 growth differentiation factor 3
GIF gastric intrinsic factor (vitamin B synthesis)
GIMAP1-GIMAP5 GIMAP1-GIMAP5 readthrough
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GLG1 golgi glycoprotein 1
GNAS GNAS complex locus
GRID2 glutamate receptor, ionotropic, delta 2
HDAC2 histone deacetylase 2
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
HES7 hes family bHLH transcription factor 7
HOXB4 homeobox B4
HS6ST1 heparan sulfate 6-O-sulfotransferase 1
HYAL2 hyaluronoglucosaminidase 2
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IDUA iduronidase, alpha-L-
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1
IGF2R insulin-like growth factor 2 receptor
ITSN1 intersectin 1 (SH3 domain protein)
KCMF1 potassium channel modulatory factor 1
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KITLG KIT ligand
KLF3 Kruppel-like factor 3 (basic)
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT14 keratin 14, type I
LFNG LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LHX3 LIM homeobox 3
LMNA lamin A/C
LPIN1 lipin 1
MAGOH mago-nashi homolog, proliferation-associated (Drosophila)
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
MCPH1 microcephalin 1
MEG3 maternally expressed 3 (non-protein coding)
MEOX2 mesenchyme homeobox 2
MITF microphthalmia-associated transcription factor
MSH2 mutS homolog 2
MTA2 metastasis associated 1 family, member 2
MUT methylmalonyl CoA mutase
MYH10 myosin, heavy chain 10, non-muscle
MYL1 myosin, light chain 1, alkali; skeletal, fast
NDN necdin, melanoma antigen (MAGE) family member
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NFE2 nuclear factor, erythroid 2
NLRP3 NLR family, pyrin domain containing 3
NOS1 nitric oxide synthase 1 (neuronal)
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NOV nephroblastoma overexpressed
NPR2 natriuretic peptide receptor 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NTAN1 N-terminal asparagine amidase
NTF3 neurotrophin 3
ORAI1 ORAI calcium release-activated calcium modulator 1
OXR1 oxidation resistance 1
PCLO piccolo presynaptic cytomatrix protein
PDLIM5 PDZ and LIM domain 5
PGAP1 post-GPI attachment to proteins 1
PLAGL1 pleiomorphic adenoma gene-like 1
PMP22 peripheral myelin protein 22
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta
PRMT3 protein arginine methyltransferase 3
PROX1 prospero homeobox 1
PRSS8 protease, serine, 8
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTK2 protein tyrosine kinase 2
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN2 protein tyrosine phosphatase, non-receptor type 2
RAI1 retinoic acid induced 1
RARG retinoic acid receptor, gamma
RELN reelin
RHOBTB3 Rho-related BTB domain containing 3
RTL1 retrotransposon-like 1
RYR2 ryanodine receptor 2 (cardiac)
SAV1 salvador family WW domain containing protein 1
SCN4A sodium channel, voltage gated, type IV alpha subunit
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SEPP1 selenoprotein P, plasma, 1
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
SETD5 SET domain containing 5
SIRT1 sirtuin 1
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group)
SLITRK1 SLIT and NTRK-like family, member 1
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMC3 structural maintenance of chromosomes 3
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
SP6 Sp6 transcription factor
SREBF1 sterol regulatory element binding transcription factor 1
STXBP5 syntaxin binding protein 5 (tomosyn)
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
SYNE1 spectrin repeat containing, nuclear envelope 1
SZT2 seizure threshold 2 homolog (mouse)
TAL1 T-cell acute lymphocytic leukemia 1
TLX2 T-cell leukemia homeobox 2
TNFAIP8L2 tumor necrosis factor, alpha-induced protein 8-like 2
TOMM5 translocase of outer mitochondrial membrane 5 homolog (yeast)
TP53 tumor protein p53
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TREX1 three prime repair exonuclease 1
TRIM21 tripartite motif containing 21
TSIX TSIX transcript, XIST antisense RNA
TYR tyrosinase
VEGFA vascular endothelial growth factor A
WNT7B wingless-type MMTV integration site family, member 7B
WWOX WW domain containing oxidoreductase
ZFP42 ZFP42 zinc finger protein
ZMPSTE24 zinc metallopeptidase STE24