decreased spleen weight Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets (Mammalian Phenotype Ontology, MP_0004953)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0004953
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Genes

58 gene mutations causing the decreased spleen weight phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AIF1 allograft inflammatory factor 1
AKAP13 A kinase (PRKA) anchor protein 13
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ASXL1 additional sex combs like transcriptional regulator 1
ATR ATR serine/threonine kinase
BAG3 BCL2-associated athanogene 3
BCL2 B-cell CLL/lymphoma 2
BRAF B-Raf proto-oncogene, serine/threonine kinase
CIDEB cell death-inducing DFFA-like effector b
COL10A1 collagen, type X, alpha 1
CORO1A coronin, actin binding protein, 1A
CSF1 colony stimulating factor 1 (macrophage)
CXCR2 chemokine (C-X-C motif) receptor 2
CXCR4 chemokine (C-X-C motif) receptor 4
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DEDD death effector domain containing
DRD2 dopamine receptor D2
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ELMOD1 ELMO/CED-12 domain containing 1
EPOR erythropoietin receptor
ERCC5 excision repair cross-complementation group 5
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FGF10 fibroblast growth factor 10
GHR growth hormone receptor
GPC3 glypican 3
GRB14 growth factor receptor-bound protein 14
GSTK1 glutathione S-transferase kappa 1
GSTZ1 glutathione S-transferase zeta 1
HOXA9 homeobox A9
IGHM immunoglobulin heavy constant mu
IL7 interleukin 7
KAT6A K(lysine) acetyltransferase 6A
KDM8 lysine (K)-specific demethylase 8
KLHL6 kelch-like family member 6
LIG4 ligase IV, DNA, ATP-dependent
LYN LYN proto-oncogene, Src family tyrosine kinase
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MST1R macrophage stimulating 1 receptor
MXRA7 matrix-remodelling associated 7
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NKX2-3 NK2 homeobox 3
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
PHC1 polyhomeotic homolog 1 (Drosophila)
PSAP prosaposin
PTP4A2 protein tyrosine phosphatase type IVA, member 2
PTTG1 pituitary tumor-transforming 1
PURA purine-rich element binding protein A
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SELENBP1 selenium binding protein 1
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
TBC1D4 TBC1 domain family, member 4
TERT telomerase reverse transcriptase
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b
TP53 tumor protein p53
WWOX WW domain containing oxidoreductase