decreased spleen germinal center number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduced number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs (Mammalian Phenotype Ontology, MP_0008482)
External Link
Similar Terms
Downloads & Tools


25 gene mutations causing the decreased spleen germinal center number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCC10 ATP-binding cassette, sub-family C (CFTR/MRP), member 10
ASL argininosuccinate lyase
BCL6 B-cell CLL/lymphoma 6
BTK Bruton agammaglobulinemia tyrosine kinase
C3 complement component 3
C4A complement component 4A (Rodgers blood group)
CD28 CD28 molecule
CD37 CD37 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CR2 complement component (3d/Epstein Barr virus) receptor 2
FAS Fas cell surface death receptor
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
ICOS inducible T-cell co-stimulator
ICOSLG inducible T-cell co-stimulator ligand
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL21 interleukin 21
ITFG2 integrin alpha FG-GAP repeat containing 2
MIR155 microRNA 155
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
REL v-rel avian reticuloendotheliosis viral oncogene homolog
SH2D1A SH2 domain containing 1A
TERC telomerase RNA component
TNF tumor necrosis factor
TRIP10 thyroid hormone receptor interactor 10
VAV2 vav 2 guanine nucleotide exchange factor