decreased single-positive t cell number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduced number of T cells bearing either CD4 or CD8 markers on their surface (Mammalian Phenotype Ontology, MP_0008083)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008083
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Genes

32 gene mutations causing the decreased single-positive t cell number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
AFF1 AF4/FMR2 family, member 1
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CD247 CD247 molecule
CRLF2 cytokine receptor-like factor 2
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1)
FOXN1 forkhead box N1
HAX1 HCLS1 associated protein X-1
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HTRA2 HtrA serine peptidase 2
IL15RA interleukin 15 receptor, alpha
IL2RG interleukin 2 receptor, gamma
IL7 interleukin 7
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
MCL1 myeloid cell leukemia 1
MYB v-myb avian myeloblastosis viral oncogene homolog
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
PKNOX1 PBX/knotted 1 homeobox 1
PNP purine nucleoside phosphorylase
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTCRA pre T-cell antigen receptor alpha
PTPN2 protein tyrosine phosphatase, non-receptor type 2
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RHOH ras homolog family member H
RUNX1 runt-related transcription factor 1
TCF7 transcription factor 7 (T-cell specific, HMG-box)
THEMIS thymocyte selection associated
VAV1 vav 1 guanine nucleotide exchange factor
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZNF335 zinc finger protein 335