decreased sensory neuron number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue and are responsible for transmission of sensory impulses (Mammalian Phenotype Ontology, MP_0000966)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0000966
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Genes

128 gene mutations causing the decreased sensory neuron number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACAN aggrecan
ADRB2 adrenoceptor beta 2, surface
AGTPBP1 ATP/GTP binding protein 1
AIPL1 aryl hydrocarbon receptor interacting protein-like 1
ALG10 ALG10, alpha-1,2-glucosyltransferase
ATF2 activating transcription factor 2
ATOH1 atonal homolog 1 (Drosophila)
ATOH7 atonal homolog 7 (Drosophila)
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2
ATP8A2 ATPase, aminophospholipid transporter, class I, type 8A, member 2
ATXN7 ataxin 7
BARHL2 BarH-like homeobox 2
BCAR3 breast cancer anti-estrogen resistance 3
BCL2 B-cell CLL/lymphoma 2
BDNF brain-derived neurotrophic factor
BHLHE22 basic helix-loop-helix family, member e22
C1QTNF5 C1q and tumor necrosis factor related protein 5
CDH23 cadherin-related 23
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CHM choroideremia (Rab escort protein 1)
CLCN3 chloride channel, voltage-sensitive 3
CLDN9 claudin 9
CLN3 ceroid-lipofuscinosis, neuronal 3
CLRN1 clarin 1
CNGA3 cyclic nucleotide gated channel alpha 3
CNGB1 cyclic nucleotide gated channel beta 1
CNGB3 cyclic nucleotide gated channel beta 3
COL11A1 collagen, type XI, alpha 1
CRB1 crumbs family member 1, photoreceptor morphogenesis associated
CYS1 cystin 1
DFNA5 deafness, autosomal dominant 5
DFNB31 deafness, autosomal recessive 31
E2F1 E2F transcription factor 1
EYA1 EYA transcriptional coactivator and phosphatase 1
FASLG Fas ligand (TNF superfamily, member 6)
FEZF2 FEZ family zinc finger 2
FGF20 fibroblast growth factor 20
FGFR1 fibroblast growth factor receptor 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXN4 forkhead box N4
GAL galanin/GMAP prepropeptide
GDF11 growth differentiation factor 11
GDF15 growth differentiation factor 15
GFI1 growth factor independent 1 transcription repressor
GUCA1A guanylate cyclase activator 1A (retina)
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUCY2D guanylate cyclase 2D, membrane (retina-specific)
HEYL hes-related family bHLH transcription factor with YRPW motif-like
HMX2 H6 family homeobox 2
HMX3 H6 family homeobox 3
HOXA2 homeobox A2
HOXB1 homeobox B1
HR hair growth associated
IGF1R insulin-like growth factor 1 receptor
JAG1 jagged 1
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1
LAMA2 laminin, alpha 2
LAMB2 laminin, beta 2 (laminin S)
LOC102723475 putative uncharacterized protein LOC388820
MERTK MER proto-oncogene, tyrosine kinase
MIR96 microRNA 96
MITF microphthalmia-associated transcription factor
MYO15A myosin XVA
MYO3A myosin IIIA
MYO6 myosin VI
MYO7A myosin VIIA
NAGLU N-acetylglucosaminidase, alpha
NDP Norrie disease (pseudoglioma)
NMNAT2 nicotinamide nucleotide adenylyltransferase 2
NRG1 neuregulin 1
NRL neural retina leucine zipper
NTF3 neurotrophin 3
NTF4 neurotrophin 4
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NTRK3 neurotrophic tyrosine kinase, receptor, type 3
NXNL1 nucleoredoxin-like 1
NXNL2 nucleoredoxin-like 2
OAT ornithine aminotransferase
OPA1 optic atrophy 1 (autosomal dominant)
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
OTX2 orthodenticle homeobox 2
PAX2 paired box 2
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PDE6G phosphodiesterase 6G, cGMP-specific, rod, gamma
POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)
POU4F2 POU class 4 homeobox 2
POU4F3 POU class 4 homeobox 3
PRPH2 peripherin 2 (retinal degeneration, slow)
PTF1A pancreas specific transcription factor, 1a
PXDN peroxidasin
RD3 retinal degeneration 3
RHO rhodopsin
RLBP1 retinaldehyde binding protein 1
RORB RAR-related orphan receptor B
RP1 retinitis pigmentosa 1 (autosomal dominant)
RP1L1 retinitis pigmentosa 1-like 1
RPGR retinitis pigmentosa GTPase regulator
RPL24 ribosomal protein L24
RS1 retinoschisin 1
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SIX1 SIX homeobox 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC26A4 solute carrier family 26 (anion exchanger), member 4
SLC26A5 solute carrier family 26 (anion exchanger), member 5
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7
SMOC1 SPARC related modular calcium binding 1
SOD1 superoxide dismutase 1, soluble
SOX2 SRY (sex determining region Y)-box 2
SRRM4 serine/arginine repetitive matrix 4
STRA6 stimulated by retinoic acid 6
THRB thyroid hormone receptor, beta
TMPRSS3 transmembrane protease, serine 3
TRIM2 tripartite motif containing 2
TSHR thyroid stimulating hormone receptor
TUB tubby bipartite transcription factor
TULP1 tubby like protein 1
TYR tyrosinase
USH1G Usher syndrome 1G (autosomal recessive)
USH2A Usher syndrome 2A (autosomal recessive, mild)
VLDLR very low density lipoprotein receptor